The Process of Freeze Drying (Lyophilization)

[Gr33dyOctopus]

View: https://youtu.be/3DsaVLiwshY?si=LfRBKYI3zDK-4Y4y


Super cool video on how the liquid is removed from our lovely little vials.

 

[yrrdead]

Get the garage setup going @Gr33dyOctopus

https://stonylab.com/products/840371302989-sb-hx-10-freeze-dryer?variant=45739136024834

 

[Labcat]

Get the garage setup going @Gr33dyOctopus

https://stonylab.com/products/840371302989-sb-hx-10-freeze-dryer?variant=45739136024834

The fact that this uses an oil pump for the vacuum serves to remind us that pump oil is an ingredient in our vials.

 

[Gr33dyOctopus]

Get the garage setup going @Gr33dyOctopus

https://stonylab.com/products/840371302989-sb-hx-10-freeze-dryer?variant=45739136024834

right?!?!

😅🤣😂

 

[Glenn]

Here is one for the garage.

View: https://www.youtube.com/watch?v=u21rStpIDE4

 

[Chopper]

The fact that this uses an oil pump for the vacuum serves to remind us that pump oil is an ingredient in our vials.

Genuinely curious, how much of a concern this might be. I guess it somewhat depends on the type of oil used and pump/system design as to how much if any would regurge out of the suction line.

 

[woundcarping]

Vacuum pumps use oil, that’s nothing new or special. Even at home freeze driers have oil sumps on their vacuum pumps.

 

[Gr33dyOctopus]

Vacuum pumps use oil, that’s nothing new or special. Even at home freeze driers have oil sumps on their vacuum pumps.

Yes, and even further, a good amount of actual fda approved drugs are lyophilized like this and reconstituted elsewhere. We just arent aware of it.

 

[Labcat]

Vacuum pumps use oil, that’s nothing new or special. Even at home freeze driers have oil sumps on their vacuum pumps.

You can get oil free pumps, they are cleaner. Modern pharmaceuticals, particularly for sensitive medications like proteins, vaccines, according to Google AI, likely uses oil free pumps because easier to keep contamination free.
Oil pumps can and doubtless use an oil mist eliminator for high quality pharmaceuticals. The question is whether grey market finishers do in their garage and how problematic the oil is for the medication efficacy and as unwanted contamination for the user. Someone could ask Jano how often they see it?

 

[Gr33dyOctopus]

You can get oil free pumps, they are cleaner. Modern pharmaceuticals, particularly for sensitive medications like proteins, vaccines, according to Google AI, likely uses oil free pumps because easier to keep contamination free.
Oil pumps can and doubtless use an oil mist eliminator for high quality pharmaceuticals. The question is whether grey market finishers do in their garage and how problematic the oil is for the medication efficacy and as unwanted contamination for the user. Someone could ask Jano how often they see it?

Well, labcat would know! I feel like there are just a couple of fairly dirty facilities pumping all this shit out. Maybe in garages for some of the more obscure stuff.

Which reminds me, qhere is this stuff really coming from, does anyone know?