The Process of Freeze Drying (Lyophilization)

The fact that this uses an oil pump for the vacuum serves to remind us that pump oil is an ingredient in our vials.
Genuinely curious, how much of a concern this might be. I guess it somewhat depends on the type of oil used and pump/system design as to how much if any would regurge out of the suction line.
 
Vacuum pumps use oil, that’s nothing new or special. Even at home freeze driers have oil sumps on their vacuum pumps.
Yes, and even further, a good amount of actual fda approved drugs are lyophilized like this and reconstituted elsewhere. We just arent aware of it.
 
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