The Process of Freeze Drying (Lyophilization)

Labcat said:
The fact that this uses an oil pump for the vacuum serves to remind us that pump oil is an ingredient in our vials.
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Genuinely curious, how much of a concern this might be. I guess it somewhat depends on the type of oil used and pump/system design as to how much if any would regurge out of the suction line.
 
woundcarping said:
Vacuum pumps use oil, that’s nothing new or special. Even at home freeze driers have oil sumps on their vacuum pumps.
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Yes, and even further, a good amount of actual fda approved drugs are lyophilized like this and reconstituted elsewhere. We just arent aware of it.
 
woundcarping said:
Vacuum pumps use oil, that’s nothing new or special. Even at home freeze driers have oil sumps on their vacuum pumps.
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You can get oil free pumps, they are cleaner. Modern pharmaceuticals, particularly for sensitive medications like proteins, vaccines, according to Google AI, likely uses oil free pumps because easier to keep contamination free.
Oil pumps can and doubtless use an oil mist eliminator for high quality pharmaceuticals. The question is whether grey market finishers do in their garage and how problematic the oil is for the medication efficacy and as unwanted contamination for the user. Someone could ask Jano how often they see it?
 
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Labcat said:
You can get oil free pumps, they are cleaner. Modern pharmaceuticals, particularly for sensitive medications like proteins, vaccines, according to Google AI, likely uses oil free pumps because easier to keep contamination free.
Oil pumps can and doubtless use an oil mist eliminator for high quality pharmaceuticals. The question is whether grey market finishers do in their garage and how problematic the oil is for the medication efficacy and as unwanted contamination for the user. Someone could ask Jano how often they see it?
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Well, labcat would know! I feel like there are just a couple of fairly dirty facilities pumping all this shit out. Maybe in garages for some of the more obscure stuff.

Which reminds me, qhere is this stuff really coming from, does anyone know?
 
I have a benchtop freeze dryer. The manufacturer says to use food-grade oil for the pump. You can buy that at farm supply stores - it's used at dairies for their milking machines.
 
yeddie said:
I have a benchtop freeze dryer. The manufacturer says to use food-grade oil for the pump. You can buy that at farm supply stores - it's used at dairies for their milking machines.
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They may be okay to ingest but they likely still contain chemical additives for stability and performance that could interact with the peptides. Just another component of the mystery composition of the HPLC spikes we don’t look at…
 
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