KYRivianMan
Member
Looks very promising…. Have the vendors started vending Mazdutide?
There has been additional data released on the stage 2 trail of Mazdutide.
- Thread starter KYRivianMan
- Start date
MrsRoper_1977
Research Enthusiast
Yes, I’ve seen it offered occasionally.
Just did a quick look to see and currently 2 out of the 3 suppliers I have ordered from in the past has it for sale....AC Peptides and QSC
Currently AmoPure is not showing it on their website...
Not making any recommedations just thought I would have a quick look...so definitly available for research
Currently AmoPure is not showing it on their website...
Not making any recommedations just thought I would have a quick look...so definitly available for research
Can you provide a link to the additional data?
peptideusername
Registered
lol no kidding. What is this post??
Broken Chef
Senior Member
Would love to see the info you are referring to!
There was a news release in late July where Innovent, who is the company conducting trials, announced the 2nd phase three trial of Maz in patients with type 2 diabetes and their plans to apply for a new drug application in China. The results seem pretty promising.
Desertteepee2
New_Member
Just found this re: Mazdutide:
www.nature.com
There’s tons of info starting to flow regarding this peptide.
Of course Eli Lilly is in bed with China on this one…so expect trouble down the road from two directions.
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity - Nature Communications
Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Here, the authors show mazdutide was well tolerated over 24 weeks and demonstrated significant and clinically meaningful body weight loss, compared with placebo, in Chinese overweight adults or adults...
www.nature.com
Of course Eli Lilly is in bed with China on this one…so expect trouble down the road from two directions.
JohnnyGobbs
New_Member
Drug looks interesting. Dual agonist but glucagon/glp instead of gip/glp
peptideusername
Registered
Mazdutide is an analog of oxyntomodulin (OXM),which is a natural hormone found in the human body, and modified to have a much longer half-life. From this paper:
Oxyntomodulin (OXM) is an endogenous dual agonist of the GCGR and GLP-1R, which increases energy expenditure and reduces food intake, leading to weight loss.[24] Moreover, administration of OXM in diet-induced insulin-resistant mice improved glucose tolerance, and this effect was also observed in T2DM patients.[25], [26] The clinical use of OXM was mainly limited by its extremely short half-life (∼10 min). Thus, several long-acting GLP-1R/GCGR dual agonists were developed, and some of them are currently tested in clinical, such as cotadutide, BI456906 and mazdutide (IBI362)
If you want the real information, look at what drug companies are telling their investors, not their customers.
Oxyntomodulin (OXM) is an endogenous dual agonist of the GCGR and GLP-1R, which increases energy expenditure and reduces food intake, leading to weight loss.[24] Moreover, administration of OXM in diet-induced insulin-resistant mice improved glucose tolerance, and this effect was also observed in T2DM patients.[25], [26] The clinical use of OXM was mainly limited by its extremely short half-life (∼10 min). Thus, several long-acting GLP-1R/GCGR dual agonists were developed, and some of them are currently tested in clinical, such as cotadutide, BI456906 and mazdutide (IBI362)
If you want the real information, look at what drug companies are telling their investors, not their customers.
That's a really nice report!
geoguy78
Registered
The effects on liver fat, combined with comparable weight loss to Tirzepatide AND lower serious adverse effects than Tirz is impressive. I'd like to see how it compares to Reta
cta7978
Member
Pemvidutide is better, more glucagon receptor agonism, less muscle mass loss.. however no real effect on HbA1C
geoguy78
Registered
I'll have to read up on that one
cta7978
Member
I think Xcelpeptides is carrying it now https://www.xcelpeptides.com/product/pemvidutide/
noteablequotable
Research Enthusiast
Looks like they are out of stock. I think that Pemv is going to be a game changer for non- responders to Sema and Tirz, as well as anyone whose weight gain is related to metabolic dysfunction.
