Thinking about switching to Sema from Reta

kagami00

kagami00

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Hi, right now I am using Reta (3mg per week) and at the beginning (1mg) everything was great, I was able to edge my weightloss results so long!! But now it feels like if I am not feeling anything at all, thats why I am thinking about titrating to 4mg per week.

But my resting heart rate went up so much, by like 20 and I dont want that. Thats why I am thinking about switching to Sema, when I start my next diet. Which dosage should I start with, and what can I expect from Sema compared to Reta?

Thanks in advance!!
 
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I hope you receive helpful guidance. No experience with Rita so I don't have anything to offer except support.
 
I'm not the biggest fan of Reta overall, it is hard on the system and I think more than most people need. It has its place, but I feel that Tirz is probably better for most people. Going to Sema does not make sense. More sides and less effect. Swapping to Tirz seems like the move. You may get some HR increase (or in this case not quite a return to base) but it is much less than Reta and studies seem to show it returning to base over around six months. Tirz will almost definitly give you less sides than Sema.

I would start low, appetite suppression will start at a much lower does than with Reta. If I were making that switch, I'd probably start with dropping my Reta down to 1mg again and adding 1mg of Tirz and go from there. You could keep the low doses of both if it works for you (I do think Reta can work well in a stack) or continue to drop Reta as you come up on Tirz.
 
Grok says,

Typical patterns:

First few weeks after a dose increase: heart rate may rise noticeably.

After several weeks to a few months: many people see the increase lessen.

Some people: continue to have a resting heart rate that stays a few beats per minute higher than before treatment.

When I first used reta it was 2mg and my heart rate increased by 17 , i stayed the course and after 7 to 10 days it went to 4 or 5 abive ny normal. (I track everything with monitor abs record it, now directly into Grok)

Sure you can bounce to sema but tons of sides with it, Trizepatide as poster above stated much less sides and works well for many.

Personally id stick with Retatrutide at 2mg for 2 weeks then move to 3 for 2 weeks. See what happens and at the same time record your heart...

Many people dont want to wait. Its not a race theres no need to keep up with tic tok or IG.

Great post!
 
I don't see the point of sema now for most people, its not really cheaper and its half as effective as Tirz. About the only reason to use it is issues with GIP agonism, which for some might be interrupting the effectiveness of the contraceptive pill although the data isn't clear yet.
 
Maybe another route is to stack reta with sema. Reta at a tolerable dose for metabolic goodies and add sema for appetite suppression. Reta is a weak GLP, but strong GIP with Glucagon. Sema is a strong GLP.
 
gusterbuster said:
Maybe another route is to stack reta with sema. Reta at a tolerable dose for metabolic goodies and add sema for appetite suppression. Reta is a weak GLP, but strong GIP with Glucagon. Sema is a strong GLP.
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That is actually what brought me here and I am glad to hear you say that. I have done sema and love the appetite suppression of it. I would consider slowly adding R to try to get the best of both worlds, but wasn't sure if it was doubling up on the GLP unnecessarily.
 
FunkyOtter said:
That is actually what brought me here and I am glad to hear you say that. I have done sema and love the appetite suppression of it. I would consider slowly adding R to try to get the best of both worlds, but wasn't sure if it was doubling up on the GLP unnecessarily.
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Works great for me. Higher doses of reta ruins my sleep and get that skin sensitivity. Sema stacked gets me that additional appetite suppression.
 
Semaglutide is the worst of the newer GLP's, it has the highest rates of side effects and the least weight loss, I really find it very hard to think of any reason to use it in preference to reta or tirz.

If your heart rate is high, maybe check it over a few days to make sure it really has gone up that much. Just checking your heart rate can make it higher, especially if you are a bit anxious. If it stays high for a few days , an increase of 20 bpm is a fair bit and not ideal, it does tend to come down slowly over a long time after starting , but swapping to tirz is a reasonable option. Any of the GLP's can raise heart rate, but reta is the only one that seems to ever cause problems.
 
Last Wednesday I stacked Sema with my typical Reta to help with food noise.

I was thinking with my high level of Reta exposure without sides I would take .25mg 2x/week. The last couple days I’ve felt rather bleh, especially yesterday evening. Bleh enough that I skipped my typical Reta dose last night waiting for the feeling to pass. The most and longest duration of bleh I’ve had by far in 26.5 weeks on this GLP ride.

I’m undecided what my plan is. It’s not a regular dose of Reta and .25mg of Sema, I’m sure of that. Maybe a step down on my Reta and .125mg of Sema. Maybe normal Reta and no Sema. Maybe something with Reta and a splash of Tirz. Maybe get back to normal on regular Reta alone and decide from there. Maybe Cagri instead of Sema or Tirz. All kinds of options.
 
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For all the good that it's done people, semaglutide is trash (relatively speaking). The only reason I can see people taking it now is because it's the only one people's insurance will cover.

But if you're doing gray anyway, the cost difference between tirz and sema is negligible enough to make this a non-issue.

Unless you're a masochist who enjoys harsher GI side effects I guess.
 
woundcarping said:
I’m undecided what my plan is. It’s not a regular dose of Reta and .25mg of Sema, I’m sure of that. Maybe a step down on my Reta and .125mg of Sema. Maybe normal Reta and no Sema. Maybe something with Reta and a splash of Tirz. Maybe get back to normal on regular Reta alone and decide from there. Maybe Cagri instead of Sema or Tirz. All kinds of options.
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And you can switch from cagri to elora at some point (or even take both cagri and elora). When there is E30 or higher, then the prices should be more reasonable for elora.
 
+3 for going to Tirz. That’s what I did because of RHR from Reta. Tirz is superior to Sema and easier to source. RHR dropped to normal after a month
 
Calm Logic said:
And you can switch from cagri to elora at some point (or even take both cagri and elora). When there is E30 or higher, then the prices should be more reasonable for elora.
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Yep, I don’t have it on hand though so it’s not a current option. I’ve pondered and postured to buy some from the current GB offerings.


Stacking Elora and Cag seems like a strange notion at this point.
 
I don’t really understand all the comments saying semaglutide is trash. It’s still a GLP-1 receptor agonist, and GLP-1 is one of the key mechanisms that also contributes to the effects of tirzepatide and retatrutide. Semaglutide was one of the first highly effective drugs in this class and is still a very effective medication.

Personally, I think it’s a great maintenance option. Beyond reducing food noise, it stopped me from biting my fingernails almost immediately after a lifetime of the habit. That’s obviously anecdotal, but a lot of my small compulsive habits and behaviors seemed to fade almost overnight and the GLP-1 seems to be the reason, not the GIP or Glucga add' ons to to the molecule.

If your goal is purely weight loss, current data suggest tirzepatide generally produces greater average weight loss than semaglutide, and many people find it to be a stronger appetite suppressant.

For my own maintenance protocol, I use semaglutide on Sundays and a small morning dose of retatrutide on Wednesdays, and that has worked well for me so far.
 
UpDownLeftRightAS* said:
I don’t really understand all the comments saying semaglutide is trash. It’s still a GLP-1 receptor agonist, and GLP-1 is one of the key mechanisms that also contributes to the effects of tirzepatide and retatrutide. Semaglutide was one of the first highly effective drugs in this class and is still a very effective medication.

Personally, I think it’s a great maintenance option. Beyond reducing food noise, it stopped me from biting my fingernails almost immediately after a lifetime of the habit. That’s obviously anecdotal, but a lot of my small compulsive habits and behaviors seemed to fade almost overnight and the GLP-1 seems to be the reason, not the GIP or Glucga add' ons to to the molecule.

If your goal is purely weight loss, current data suggest tirzepatide generally produces greater average weight loss than semaglutide, and many people find it to be a stronger appetite suppressant.

For my own maintenance protocol, I use semaglutide on Sundays and a small morning dose of retatrutide on Wednesdays, and that has worked well for me so far.
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Absolutely fair statement, but I think the folks slamming semaglutide are going to be people like me who took it for weight loss, didn't have a great experience on it, weren't getting as much weight loss as they would like, increased the dose accordingly, and then fought brutal GI side effects.

Those same people would switch to tirzepatide and would find it to be both more effective and elicit fewer side effects.

In retrospect I wish when I started this whole journey I would have just started on tirzepatide or probably retatrutide.
 
Stats are that side effects bad enough to discontinue Sema were 5-10 percent of patients. I'm not discounting their experiences but to call Sema a shit drug is reaching.

I think Sema's beauty lies in the GLP only agonist, so stacks beautifully with Reta or Tirz to get a little more appetite suppression without overlapping GIP.
 
Damn I really want to thank ya'll for contributing on this thread, it means much to me because I learned more about GLPs than ever. Really, thank you.

I might just really use Tirz and maybe stack it with a low dose of reta, we will see!!
 
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