Threw up twice this week.

Peps-Enthusiast

Peps-Enthusiast

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Fifty-five years. I've thrown up maybe ten times, seven of those times because I was young and drinking way too much. I never throw up, but I threw up twice this week. I am fairly confident it has something to do with my digestion and peptides, probably RETA and Cagri specifically. I didn't eat anything crazy. My wife and kid ate exactly the same food I ate all day. The only thing I did differently was I ate a little bit later than I normally do and a little bit larger portion than I normally do, but not a crazy big portion, just more than usual.

I suspect this is not the most uncommon thing when taking peptides that slow down your digestion. I was just wondering if anybody had any experience with this. Fyi, i'm week 14 on reta 2.5mg/2x week, I added cagri .5mg/2x week a couple weeks ago, also on klow AD5 mots and tesa.
 
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Peps-Enthusiast said:
Fifty-five years. I've thrown up maybe ten times, seven of those times because I was young and drinking way too much. I never throw up, but I threw up twice this week. I am fairly confident it has something to do with my digestion and peptides, probably RETA and Cagri specifically. I didn't eat anything crazy. My wife and kid ate exactly the same food I ate all day. The only thing I did differently was I ate a little bit later than I normally do and a little bit larger portion than I normally do, but not a crazy big portion, just more than usual.

I suspect this is not the most uncommon thing when taking peptides that slow down your digestion. I was just wondering if anybody had any experience with this.
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I threw up my first week on tirz, 2.5mg (I'm drug sensitive)...had bad hiccups...acid reflux...The acid reflux stayed with me the first 2-3 weeks, mostly at night. I took Tums a lot. I went up to 5mg after 4 weeks and 7.5mg after 12 weeks. No stomach issues at all now. The body adjusts to it, but I also started on BPC-157 and KPV, and I think they have helped a lot with the digestion problems...At any rate, the symptoms do get better pretty quickly....GL!
 
Peps-Enthusiast said:
Fifty-five years. I've thrown up maybe ten times, seven of those times because I was young and drinking way too much. I never throw up, but I threw up twice this week. I am fairly confident it has something to do with my digestion and peptides, probably RETA and Cagri specifically. I didn't eat anything crazy. My wife and kid ate exactly the same food I ate all day. The only thing I did differently was I ate a little bit later than I normally do and a little bit larger portion than I normally do, but not a crazy big portion, just more than usual.

I suspect this is not the most uncommon thing when taking peptides that slow down your digestion. I was just wondering if anybody had any experience with this. Fyi, i'm week 14 on reta 2.5mg/2x week, I added cagri .5mg/2x week a couple weeks ago, also on klow AD5 mots and tesa.
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It's very likely due to Cagri I tried Cagri too, at .5 mg, and noticed that as soon as I ate a little more, I had to lie down right away because I felt nauseous. What I can recommend is that you stop taking Cagri and switch to a higher dose of Reta if you don't like how it suppresses your appetite.
 
I had severe nausea twice since starting reta. First time was 2 days after first dose of 2mg. Stupid me felt fine day 1, had several beers and leftovers before bed. Few hours later I woke abruptly with the nausea feeling reminiscent of my childhood stomach virus. Didn't puke but I was wrecked the next day. 2nd time, new vial from a different source on a titrate up week. Shortly after laying down, needed to get back up to use the bathroom. Some reason nausea hit me again. Still didn't puke but felt like death for a while. I just have to be careful with dosing starting new vials.
 
Bluecost10 said:
It's very likely due to Cagri I tried Cagri too, at .5 mg, and noticed that as soon as I ate a little more, I had to lie down right away because I felt nauseous. What I can recommend is that you stop taking Cagri and switch to a higher dose of Reta if you don't like how it suppresses your appetite.
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I think you're right. That's the newest addition to the stack, and I went up to .5mg from .25mg. I'm going to go back down to .2mg to see what happens.
 
BNLFL said:
How did you eat more on Reta? I basically have to force feed myself.
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Funny thing about Reta, I'm never hungry, until I start eating. once I start eating I'm hungry and I can eat plenty. I mostly don't because , well, you know. But this week, I ate a bit more than I usually would and both times I got smacked upside the g.i. tract, hard. Woke up 3am, bloated, gassy, and super uncomfortable, I knew i'd eventually throw up based on the miserable taste from the burping. A couple hours later, bam, 2 lbs lighter.
 
Reta gave me an insane amount of hunger, but never nausea it made me want to eat a horse and gave me a boost in energy. I never tried Cag, and never threw up on a glp.

I would recommend stopping the Cag altogether, ppl report having GI issues while on it. And recalibrate your Reta pin days w/when you're going to eat a lot of food, I can usually eat huge meals around day 4 onwards w/o any GI discomfort.

And what do you mean by "eat a little more than usual" did you feel comfortable eating it or did ur stomach feel tight and/or did u feel nauseous?
 
Peps-Enthusiast said:
Fifty-five years. I've thrown up maybe ten times, seven of those times because I was young and drinking way too much. I never throw up, but I threw up twice this week. I am fairly confident it has something to do with my digestion and peptides, probably RETA and Cagri specifically. I didn't eat anything crazy. My wife and kid ate exactly the same food I ate all day. The only thing I did differently was I ate a little bit later than I normally do and a little bit larger portion than I normally do, but not a crazy big portion, just more than usual.

I suspect this is not the most uncommon thing when taking peptides that slow down your digestion. I was just wondering if anybody had any experience with this. Fyi, i'm week 14 on reta 2.5mg/2x week, I added cagri .5mg/2x week a couple weeks ago, also on klow AD5 mots and tesa.
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I never got sick and threw up but every once in a while I would get very nauseous or have a "potty day"...all day. I'm on a similar stack as you.
 
TazaTaza said:
Reta gave me an insane amount of hunger, but never nausea it made me want to eat a horse and gave me a boost in energy. I never tried Cag, and never threw up on a glp.

I would recommend stopping the Cag altogether, ppl report having GI issues while on it. And recalibrate your Reta pin days w/when you're going to eat a lot of food, I can usually eat huge meals around day 4 onwards w/o any GI discomfort.

And what do you mean by "eat a little more than usual" did you feel comfortable eating it or did ur stomach feel tight and/or did u feel nauseous?
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These are relative measures. I used to eat two full plates of food, which was 1.3x-1.5x the right amount. Now relative to that I eat .5-.7 of a plate of food for dinner most nights. On the nights I threw up I ate a full plate, maybe slightly more, but I also went up to .5mg cag just prior. I'm now fairly confident if Cag wasn't involved, I wouldn't have had these issues. At .25mg Cag, i don't recall any issues, so I will skip the next shot, and then go back down to .2mg, and reevaluate.
 
Hard to say without knowing the specific foods you've been eating. You can go super basic: chicken soup with only carrots and potato and/or small plate of plain eggs and oatmeal (without milk) and gradually build up from there. Also, you can just stop pinning 1-2+ weeks and see if you get back to normal. Maybe try KPV and see if it helps the gut.
 
headward said:
Hard to say without knowing the specific foods you've been eating. You can go super basic: chicken soup with only carrots and potato and/or small plate of plain eggs and oatmeal (without milk) and gradually build up from there. Also, you can just stop pinning 1-2+ weeks and see if you get back to normal. Maybe try KPV and see if it helps the gut
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My diet has been consistent for months, as has my digestion. Latte in the morning, protein shakes late morning and early afternoon, occasionally a salad as well. I generally eat some kimchi with most meals, some sort of protein, a soft boiled egg or two, and a small amount of white rice. I'm running 1700-2000 calories a day, and I'm 6'5 265 (now - I was 301). I also lift weights daily, and run walk hike 3-4 days a week, so I'm burring up way more calories than I'm eating. I could always feel the slow digestion with Reta, but Cagri hits like a ton of bricks and is stopping digestion altogether, at least at the higher dose. It's a real firecracker, but a useful one if you can handle the heat.
 
Peps-Enthusiast said:
My diet has been consistent for months, as has my digestion. Latte in the morning, protein shakes late morning and early afternoon, occasionally a salad as well. I generally eat some kimchi with most meals, some sort of protein, a soft boiled egg or two, and a small amount of white rice. I'm running 1700-2000 calories a day, and I'm 6'5 265 (now - I was 301). I also lift weights daily, and run walk hike 3-4 days a week, so I'm burring up way more calories than I'm eating. I could always feel the slow digestion with Reta, but Cagri hits like a ton of bricks and is stopping digestion altogether, at least at the higher dose. It's a real firecracker, but a useful one if you can handle the heat.
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Reta + cagri slow gastric emptying and appetite, so latte/dairy, repeated protein shakes, kimchi/fermentation, salad fiber, eggs/fat, and rice volume can sit longer. Thus, gas/nausea.

You might consider reducing shakes to 1/day, go lactose-free, cut kimchi/salad temporarily, smaller meals, lower fat, and hydrate/electrolytes.
 
Wedding a few weeks back, stopped for fast food on the way home, instant heartburn, hiccuped for 3 hours before I puked it all up. (I only had 3 drinks over 7 hours)
 
headward said:
Reta + cagri slow gastric emptying and appetite, so latte/dairy, repeated protein shakes, kimchi/fermentation, salad fiber, eggs/fat, and rice volume can sit longer. Thus, gas/nausea.

You might consider reducing shakes to 1/day, go lactose-free, cut kimchi/salad temporarily, smaller meals, lower fat, and hydrate/electrolytes.
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I sip the protein shake a few times, barely drink half. Eating very small portions.
 
Both reta and cagri have pretty high rates of nausea and vomiting , around 50% of people will get varying degrees of it from either of them. The only study showing cagri with anything else was cagrisema, which had very high rates of nausea and vomiting. So increasing doses of reta could be responsible, but adding cagri on top is even more likely. What you have is at the very mild end of the spectrum of side effects. If you cannot fix the problem by physical means , like eating less at a time and reducing drinks with food to limit gastric filling, then you might have to drop back on doses a bit for a while, but this side effect does typically get better slowly over time. Curious as to why you added cagri in a such a low reta dose, rather than just increase reta?
 
lessthanhalf said:
Both reta and cagri have pretty high rates of nausea and vomiting , around 50% of people will get varying degrees of it from either of them. The only study showing cagri with anything else was cagrisema, which had very high rates of nausea and vomiting. So increasing doses of reta could be responsible, but adding cagri on top is even more likely. What you have is at the very mild end of the spectrum of side effects. If you cannot fix the problem by physical means , like eating less at a time and reducing drinks with food to limit gastric filling, then you might have to drop back on doses a bit for a while, but this side effect does typically get better slowly over time. Curious as to why you added cagri in a such a low reta dose, rather than just increase reta?
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I wasn't aware that my Reta dose was particularly low at 14 weeks. I keep reading about people that are 3x my dose and I'd prefer to keep all mgs down to the bare minimum needed. Cagri seemed a good choice, since the dosages are fairly low (especially as compared to Reta), and I think I almost nailed the balance, except I went up too much too fast, due to pure ignorance. The same stack with .25mg cagri was money, I had no idea that an additional .25mg would be a nuclear bomb, especially since i stack a ton of peptides daily/weekly and I have exactly zero side effects, until this one.

It stands to reason, that if I go down to .2 cagri, I should be right back to totally fine, and then I can wait and see how my hunger feels about it.
 
Peps-Enthusiast said:
I wasn't aware that my Reta dose was particularly low at 14 weeks. I keep reading about people that are 3x my dose and I'd prefer to keep all mgs down to the bare minimum needed. Cagri seemed a good choice, since the dosages are fairly low (especially as compared to Reta), and I think I almost nailed the balance, except I went up too much too fast, due to pure ignorance. The same stack with .25mg cagri was money, I had no idea that an additional .25mg would be a nuclear bomb, especially since i stack a ton of peptides daily/weekly and I have exactly zero side effects, until this one.

It stands to reason, that if I go down to .2 cagri, I should be right back to totally fine, and then I can wait and see how my hunger feels about it.
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I got some Cagril 10 just to have it on hand...a 10mg vial seemed like a lot for the kind of doses I would use, but it'll live in the tool box until I think it might help get over a hump or whatever...I'm with you though 250mcg may be too much...😳
 
Every other peptide I've used, if you accidentally over do it or under do it, no big deal. Cag however, is a very big deal and will absolutely blow up a couple days of your life with its unforgiving profile. Too much klow bpc, AD5, Mots, kpv, kp, dsip, no big deal.
 
I was just curious as to the reason for using both, rather than increasing reta. I think there are good theoretical reasons for combining fairly lowish doses of reta or tirz with cagri or elora, as it might be the optimal combination for lowest rates of side effects for highest weight loss. With reta 1mg 9% and elora 1mg 9% weight loss, and reta 4mg 19% elora 3mg 13% weight loss- if the results are additive it could be amazing. I am on cagri 0.25 mg every 4 days ( with tirz15/reta5mg) and any attempts at higher doses definitely increase nausea. I could not find the complete cagri studies, just the abstracts when I tried to find accurate side effect rates.
 
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