Time to change up the rotation!

[Thee Oohwee]

Wassup Peppers,

It's time to change up the rotation. I was on Tirz at 10mg before I started to transition to Reta. Here's what I have been pinning:

1. Reta 8mg/week (I'm on week #2 at this dose) on Monday
2. Tirz 5mg/week (I'm on week #2 at this dose) on Friday

I have been having an absolute aversion to food. Have to force myself to eat breakfast and lunch. I thought, based on what I read about Reta, I would need the extra food noise suppression from keep Tirz in rotation. No, absolutely not - in my case. And I have been super tired on Tuesdays and Wednesdays after Reta shot. I'm pretty sure its the Tirz that I do not need right now.

Also, even with having an electrolyte drink every day and eating healthy carbs (potatoes, rice) I was still getting very dizzy if I squatted for too long and stood up. To the point of feeling like I was gonna pass out. Wondering if I was doing too much with this GLP stack?

Still in the gym 4x/week weighlifting. Trying to get in at least 130-150g of protein daily. I think I need to take in some more - I'm at 183lbs currently, and want to convert fat into muscle at this point. Not really wanting to weigh too much less.

Anyone else dealing with moving from Tirz to Reta? Or stacking both throughout the week? Please share what works great for y'all. I'm all ears.

 

[Cannonball72]

You started your first dose of Reta at 8mg? Or did you titrate up to there?

And also pinned 5mg tirz, alternating with 8mg of Reta? For a total of 13mg?

And you don’t want to lose weight?

This sounds like a-lot of Reta based on my experience, I’m a big advocate of starting low and finding minimum effective dose.

I’ve been on Reta since beginning of Feb, started at 1mg/wk split. Slowly worked up to 4mg split (just this week). Lost 20lbs with consistent training. See plenty of runway for current level and will dial back in about 15lbs to lowest effective maintenance dose.

I would highly encourage considering dialing it back.

 

[thorien]

I'm currently on 3.5mg Tirz. Started at 2.5, 7 months ago, highest I got to was 3.75 every 5 days. I'm considering starting reta next week at 1.5mg for 4 weeks every 5 days then going up to 2mg whilst reducing my Tirz to 2.5mg every 5 days. I'm honestly thinking even this may be too much so yeah I'd say reduce your dosage of both!

 

[wheymaster1]

It’s too much to stack tirz and reta at the same time. Slowly wean off of tirz and keep just reta. Increase dose of Reta if necessary, go to 12 mg if needed like in the studies.

 

[5byfive]

I have been having an absolute aversion to food. Have to force myself to eat breakfast and lunch.

Three words: Minimum effective dose.

 

[Thee Oohwee]

Thanks for the tips and experience everybody. I titrated my way up to 8mg of Reta. The Tirz was on a different day.

I am stopping Tirz effective immediately and reevaluating Reta for the rest of this month. I may go down to 6mg if food aversion is still strong. I think it will be better once Tirz is gone.

 

[DragonOfTheSea]

Thanks for the tips and experience everybody. I titrated my way up to 8mg of Reta. The Tirz was on a different day.

I am stopping Tirz effective immediately and reevaluating Reta for the rest of this month. I may go down to 6mg if food aversion is still strong. I think it will be better once Tirz is gone.

It will be different, at least it was for me and I’ve seen a lot of people agree- the relationship to food on Tirz is significantly different than on Reta. For me, Tirz just mutes it all so well, Reta allows hunger (sometimes intense) but you get full incredibly quickly.

I started with Tirz, up to 7.5mg. I cross titrated Reta up starting @ 2mg while backing off Tirz.

I, like you, decided to try Reta alone to evaluate. I’m currently sitting at 6mg Reta (split dosed) and took my last shot of Tirz April 3rd, waiting for it to completely leave the system takes over a month (well, depending on what level you stopped at).

I get hungry 1-2x/day, but meal sizes are quite small as I’m full after 7-8 bites of anything nutritionally dense. I ensure I’m hitting numbers drinking lots of protein and fiber across the entire day, hungry or not, and supplementing with vitamins.

Over the last month I’ve been assessing just Reta vs Tirz or both, I feel confident that I will stick to this solo until I shift to maintenance, at which point I’m unsure what I will use for low dosage maint. but will cross that bridge when I get there.

 

[SoCalGirl]

Using Reta 3mg and Cagri .5mg. Last month or so, during workouts, I have to stop and bend over, absolutely lightheaded, dizzy, and feel like passing out. I have always had low BP, so it is not high BP causing the problem. I've ordered some electrolytes. I'm eating enough, decent-ish macros. I've drunk enough water. I have read that Reta causes dizziness as a side effect. I really want this to go away.

 

[DragonOfTheSea]

Using Reta 3mg and Cagri .5mg. Last month or so, during workouts, I have to stop and bend over, absolutely lightheaded, dizzy, and feel like passing out. I have always had low BP, so it is not high BP causing the problem. I've ordered some electrolytes. I'm eating enough, decent-ish macros. I've drunk enough water. I have read that Reta causes dizziness as a side effect. I really want this to go away.

how is your carbohydrate consumption? low?

 

[SoCalGirl]

how is your carbohydrate consumption? low?

LOL - NO - I'm an equal opportunity eater. Great blend of macros. Including some measured treats (sugar babies - need we say more 🤣) and good protein and avocados.

 

[lessthanhalf]

Wassup Peppers,

It's time to change up the rotation. I was on Tirz at 10mg before I started to transition to Reta. Here's what I have been pinning:

1. Reta 8mg/week (I'm on week #2 at this dose) on Monday
2. Tirz 5mg/week (I'm on week #2 at this dose) on Friday

I have been having an absolute aversion to food. Have to force myself to eat breakfast and lunch. I thought, based on what I read about Reta, I would need the extra food noise suppression from keep Tirz in rotation. No, absolutely not - in my case. And I have been super tired on Tuesdays and Wednesdays after Reta shot. I'm pretty sure its the Tirz that I do not need right now.

Also, even with having an electrolyte drink every day and eating healthy carbs (potatoes, rice) I was still getting very dizzy if I squatted for too long and stood up. To the point of feeling like I was gonna pass out. Wondering if I was doing too much with this GLP stack?

Still in the gym 4x/week weighlifting. Trying to get in at least 130-150g of protein daily. I think I need to take in some more - I'm at 183lbs currently, and want to convert fat into muscle at this point. Not really wanting to weigh too much less.

Anyone else dealing with moving from Tirz to Reta? Or stacking both throughout the week? Please share what works great for y'all. I'm all ears.

You are describing postural hypotension, where your blood pressure does not adequately increase to account for changes in position, which causes inadequate brain blood flow, dizzyness, faintness, vision going grey etc. It can definitely cause you to faint, so you do need to be a bit careful - if you feel you might faint , get your head lower quickly.

I do not know if you have lost a lot of weight. That alone can cause it. Reta and tirz both also reduce blood pressure. The loss of fluid that comes with weight loss can cause it. Inadequate water and salt or electrolyte intake can cause it. Reduced food intake will result in lower electrolyte and salt intake. GLP drugs can reduce thirst and result in low fluid intake. And changes in regional blood flow with exercise can mean the blood is going to your muscles and not enough left to get to your brain.

If you are not trying to lose more weight and are struggling to eat enough then obviously you need to drop the doses of one or the other of tirz or reta, and it sounds like you are planning to do that. That might fix the problem, or you might need to focus on fluid and electrolyte intake, but without knowing the context it is pretty hard to guess how to fix it.

I started getting it 3 years ago while losing weight and it is still there, but in my case it is the weight loss itself as I have dropped 80kg.

 

[lessthanhalf]

Using Reta 3mg and Cagri .5mg. Last month or so, during workouts, I have to stop and bend over, absolutely lightheaded, dizzy, and feel like passing out. I have always had low BP, so it is not high BP causing the problem. I've ordered some electrolytes. I'm eating enough, decent-ish macros. I've drunk enough water. I have read that Reta causes dizziness as a side effect. I really want this to go away.

Rather than just copy/paste the answer above, the answer is the same, apart from dropping the doses. Any slightly better answer would require much more info. But in the context of exercise be careful, and if your body warns you it might faint , take it seriously or you might, and the immediate solution is to get your head lower relative to your heart. I have fainted and puked after weightlifting and on a diet and not eating much that day, a long time ago, but it can happen. Electrolytes seem like a reasonable thing to try , maybe timing of food before exercise?

 

[Zydeceltico]

You are describing postural hypotension, ........

This

 

[Thee Oohwee]

You are describing postural hypotension, where your blood pressure does not adequately increase to account for changes in position, which causes inadequate brain blood flow, dizzyness, faintness, vision going grey etc. It can definitely cause you to faint, so you do need to be a bit careful - if you feel you might faint , get your head lower quickly.

I do not know if you have lost a lot of weight. That alone can cause it. Reta and tirz both also reduce blood pressure. The loss of fluid that comes with weight loss can cause it. Inadequate water and salt or electrolyte intake can cause it. Reduced food intake will result in lower electrolyte and salt intake. GLP drugs can reduce thirst and result in low fluid intake. And changes in regional blood flow with exercise can mean the blood is going to your muscles and not enough left to get to your brain.

If you are not trying to lose more weight and are struggling to eat enough then obviously you need to drop the doses of one or the other of tirz or reta, and it sounds like you are planning to do that. That might fix the problem, or you might need to focus on fluid and electrolyte intake, but without knowing the context it is pretty hard to guess how to fix it.

I started getting it 3 years ago while losing weight and it is still there, but in my case it is the weight loss itself as I have dropped 80kg.

Thanks for this thorough response!

I have been researching, researching, researching since I originally posted this question. I helped my body to even out by doing three things:

1. Eating more healthy carbs, i.e. potatoes, rice.
2. Coming completely off Tirz and just keeping the Reta.
3. Drinking electrolytes everyday.

Now, I only get brief dizziness, usually around dosing day, but nowhere as bad as what was happening before. As I understand, a lot of folks fail to realize they need to be eating some kind of good carbohydrates while on Retatutride, and like I did, they just focus mainly on protein. It can cause a lot of disruption in the body and viola, more dizziness.

 

[SoCalGirl]

You are describing postural hypotension, where your blood pressure does not adequately increase to account for changes in position, which causes inadequate brain blood flow, dizzyness, faintness, vision going grey etc. It can definitely cause you to faint, so you do need to be a bit careful - if you feel you might faint , get your head lower quickly.

I do not know if you have lost a lot of weight. That alone can cause it. Reta and tirz both also reduce blood pressure. The loss of fluid that comes with weight loss can cause it. Inadequate water and salt or electrolyte intake can cause it. Reduced food intake will result in lower electrolyte and salt intake. GLP drugs can reduce thirst and result in low fluid intake. And changes in regional blood flow with exercise can mean the blood is going to your muscles and not enough left to get to your brain.

If you are not trying to lose more weight and are struggling to eat enough then obviously you need to drop the doses of one or the other of tirz or reta, and it sounds like you are planning to do that. That might fix the problem, or you might need to focus on fluid and electrolyte intake, but without knowing the context it is pretty hard to guess how to fix it.

I started getting it 3 years ago while losing weight and it is still there, but in my case it is the weight loss itself as I have dropped 80kg.

OH MAN, three years later and you still have it? CRAPPPO. I was so hoping it would pass in a few weeks. Mine could be the weightloss. I never weigh myself, but at the Dr.s the other day, I noticed I had dropped about 10 pounds in a month. I thought it was from not playing 3 hours of pickleball each day (damn knee injury), and figured it was muscle loss, but maybe it was just continuing weight loss.

Can you not do anything about the dizzy thing? Electrolytes didn't help?