Tirz First Week

[lessthanhalf]

This is my first week of tirz (2.5mg). I am coming over from wegovy 1mg pens. I wanted to start tirz at 5mg but I was nervous about side effects so i choose to begin on the starter dose.

No crazy side effects just a bit of burping but that went away in a day. I did notice that i felt appetite suppression within a few hours of injecting tirz which never happened to me on wegovy. I was pleasantly surprised.

However, i feel it wearing off by day 4. Im just now learning that the half life of tirz is 5 days not 7 like sema. I think i will go up to 5mg for my next dose and probably do every 5 days.

By the way i lost about 30lbs on wegovy in 3 months. Im looking forward to tirz i just have to find the right dose that works for me.

I spent ages trying to work out what dose of tirzepatide might be equivalent to my dose of semaglutide, and calculated that 0.8mg/w sema would be somewhere around 3-5mg of tirz. As I had not discovered grey peptides it was only going to work if the dose was small and I could make each 60mg pen last at least 3-4 months, at $690 Aud / pen.
In the end it turned out completely different . Despite pretty bad nausea on 0.2mg of sema every 2 days, I had hardly any from tirz and not as much appetite suppression either, and to get hunger under control a bit better than sema ended up at 15mg of tirz, but with a lot less side effects. Thankfully I found this forum and cheap chinese peptides which solved the cost problem.
Effects and side effects from the different GLP's seem to be different for different people and any conversion chart is a loose guide at best, and you need to work out doses on hunger control and side effects.

 

[hoobz]

I choose to still start at 2.5mg tirz just to be on the safe side but honestly by the third day i felt the appetite suppression gone so im thinking maybe i needed to start at 5mg.

Nice chart, thanks!

Some people like to go inbetween the "official" doses, like for example go from 2.5 to 3.75, instead of 5.
I think this is what I'm going to do once 2.5 stops working well. I intend to keep as low as possible. But then again it might not work for everyone, some people, being slow responders might need more. Let us know how it goes for you and wish you the best!

 

[lessthanhalf]

I think the official dose increments for tirz are pretty good, just going up 2.5 no matter what the dose with lower odds of bad side effects.

I think if you already have mild tolerable side effects , it is a good indication to either not increase the dose or increase by a small amount, to minimise the risks of being hit with suddenly very unpleasant effects.

Reta with 2 4 8 12 is a bit less conservative, and I would add 6 and 10mg in there

Semaglutide is not as well thought out 0.25 0.5 1 1.7 2.4, but the later drugs had more time and experience to fine tune the schedule. The jump from 0.5 to 1mg is not a good idea, and should be to 0.75, especially given it tends to cause more GI side effects anyway.

 

[Elocin]

I previously used prescription Ozempic, and found it very ineffective. The only thing it did was give me really bad constipation lol. It was a waste of $ for me.

When I started Tirz, I did a lot of reading, and decided I wanted to go the every 5 day route.
First pin I did 1mg. Second I did 1.5mg. I’ll be honest, I didn’t feel anything after the first pin, but after the 2nd, the appetite suppression kicked in hard. Which is exactly what I need to reel in my binge eating. I can eat no problem, it’s just a lot less, which is amazing. Not sure if I will pin #3 at 1.5mg again, or do 2mg.

My husband on the other hand.. he seems to be very sensitive to GLP1’s. Poor guy had awful gastro side effects on the Ozempic, and it looks to be the same with Tirz. Funny how different everyone reacts.

 

[CornPop]

I previously used prescription Ozempic, and found it very ineffective. The only thing it did was give me really bad constipation lol. It was a waste of $ for me.

When I started Tirz, I did a lot of reading, and decided I wanted to go the every 5 day route.
First pin I did 1mg. Second I did 1.5mg. I’ll be honest, I didn’t feel anything after the first pin, but after the 2nd, the appetite suppression kicked in hard. Which is exactly what I need to reel in my binge eating. I can eat no problem, it’s just a lot less, which is amazing. Not sure if I will pin #3 at 1.5mg again, or do 2mg.

My husband on the other hand.. he seems to be very sensitive to GLP1’s. Poor guy had awful gastro side effects on the Ozempic, and it looks to be the same with Tirz. Funny how different everyone reacts.

I think it’s smart to take it slow and only go up if necessary. I will say the first couple weeks I was doing great with no issues and then the third week I was so irritated. Especially at night. Just irrational irritation and moodiness.

I got some magnesium and did a full day fast and I’ve been much better. I think my body was not used to being at such a deficit and wasn’t burning my fat stores. By fasting I was forcing my body to use the stored fat. It was shocking how much it helped.

 

[Elocin]

my only side effects on the first day was the anxiety i gave myself for wondering if this is even a good idea, but i'm over it 😀

I relate so much to this!! lol. I have really bad anxiety and panic disorder. Was able to talk myself down, thankfully 😅

 

[Not_Your_Dad]

I previously used prescription Ozempic, and found it very ineffective. The only thing it did was give me really bad constipation lol. It was a waste of $ for me.

When I started Tirz, I did a lot of reading, and decided I wanted to go the every 5 day route.
First pin I did 1mg. Second I did 1.5mg. I’ll be honest, I didn’t feel anything after the first pin, but after the 2nd, the appetite suppression kicked in hard. Which is exactly what I need to reel in my binge eating. I can eat no problem, it’s just a lot less, which is amazing. Not sure if I will pin #3 at 1.5mg again, or do 2mg.

My husband on the other hand.. he seems to be very sensitive to GLP1’s. Poor guy had awful gastro side effects on the Ozempic, and it looks to be the same with Tirz. Funny how different everyone reacts.

Have hubs consider Reta - I switched from high-dose Tirz and the gastro sides are almost non-existent for me. I went full send on it too, started at 2 mg and titrated up to 6 mg every 84 hours over 8 weeks.

On the whole, I think it's reasonable to keep the dose you're on as long as it's effective for your goals. I've heard of some folks never going over 5 mg and losing 40% of their body weight. Mrs. NYD has lost over 50% of her body weight but had to work up to 10 mg every 84 hours and now she's transitioning over to Reta as the GI sides have been absolutely brutal for her at that dose.

 

[Elocin]

Have hubs consider Reta - I switched from high-dose Tirz and the gastro sides are almost non-existent for me. I went full send on it too, started at 2 mg and titrated up to 6 mg every 84 hours over 8 weeks.

On the whole, I think it's reasonable to keep the dose you're on as long as it's effective for your goals. I've heard of some folks never going over 5 mg and losing 40% of their body weight. Mrs. NYD has lost over 50% of her body weight but had to work up to 10 mg every 84 hours and now she's transitioning over to Reta as the GI sides have been absolutely brutal for her at that dose.

50% is amazing!!
Other than the GI issues, any other side effects titrating every 84 hours?

I will definitely talk to him about Reta. I think he would be willing to try, if the GI stuff stops.

 

[Not_Your_Dad]

50% is amazing!!
Other than the GI issues, any other side effects titrating every 84 hours?

I will definitely talk to him about Reta. I think he would be willing to try, if the GI stuff stops.

She had slightly less difficult GI sides with 10 mg / 84 hours, but it was still rough for her.

For me on Reta, no. I was at either 12.5 or 15 on Tirz and for 48 hours after that shot I felt like I got hit by a train. And the GI sides were awful. Plus I had stalled on loss for 8-12 weeks (I don't remember any more). I would have dealt with the sides if I continued to lose, but with no loss, I couldn't do it any more. The worst I have with Reta, even with this high dose I'm on, is a little nausea now and then. I find that I just absolutely don't want to eat, and I'll go 18 hours on maybe 300 calories and then I'll get so nauseous that I have to eat something. Mentally I'd be fine not eating for 2 or 3 days, I suspect, but I get such a strong physical reaction to it (and lets be real, as humans we should not just voluntarily want to eat only every 72 hours) that I have to eat.

 

[Elocin]

She had slightly less difficult GI sides with 10 mg / 84 hours, but it was still rough for her.

For me on Reta, no. I was at either 12.5 or 15 on Tirz and for 48 hours after that shot I felt like I got hit by a train. And the GI sides were awful. Plus I had stalled on loss for 8-12 weeks (I don't remember any more). I would have dealt with the sides if I continued to lose, but with no loss, I couldn't do it any more. The worst I have with Reta, even with this high dose I'm on, is a little nausea now and then. I find that I just absolutely don't want to eat, and I'll go 18 hours on maybe 300 calories and then I'll get so nauseous that I have to eat something. Mentally I'd be fine not eating for 2 or 3 days, I suspect, but I get such a strong physical reaction to it (and lets be real, as humans we should not just voluntarily want to eat only every 72 hours) that I have to eat.

Thanks for all your insight!! Definitely gave hubs something to think about.

 

[fatjacked]

my first week was a lot like OP's, the food noise dropped dramatically and one of the first things i noticed was how much better my energy was in the afternoons (i would always get super sleepy around 2-3PM after usually eating a terrible, huge lunch). my goal was to go low and slow, and in those first couple weeks i felt like i could have stayed at 2.5 forever. but i did find that the appetite suppression was weaker after 3-4 weeks at the same dose, and i ended up titrating up only a little bit slower than the original recommended protocols (currently 4 months in and at 7.5 mg). personally i am not that far from my goal weight and i am willing to be patient in order to minimize muscle loss.

 

[ScienceHippo]

My first week on compounded tirz @ 2.5 I felt it within 24 hours. No appetite. And it lasted most of the week. By the fourth week on 2.5 the food noise was coming back faster and faster. Titrated to 5 which is still working for me. Only a couple months in though. Have some gray orders but haven't pinned it yet, still have a vial of compounded to use.