Tirz to Reta - feedback pls

[Lifeworthliving]

I've been on Tirz 12.5 mg since Dec. 2024, I've lost 80 lbs. Insurance dropped all GLP1s, so I'm rotating into Reta to lose the last 50lbs. I've stalled on Tirz, despite higher protein intake (150g a day for a 200-pound female), lifting weights four days a week, cycling on off-weight days, logging, etc. I feel stronger from lifting, and there may be some conversion of fat to muscle, but the scale isn't moving.

I also really wonder about where my weight has settled. Two kids later, my weight is disproportionately concentrated in my hips and thighs. I'm two dress sizes larger in pants than in dresses or tops.

Questions -

I'm going to start at 2mg of Reta, but since I've been on a higher dose of Tirz for a while, I may increase it after the first two weeks. I'm going to listen to my body and play it by ear; I know it takes time to build up.

Half Life - What is the ideal half-life schedule? Do I dose every 5 days, or split up my dose, if 2mg total, 1mg on Sunday, and another on Wednesday?

 

[hexagonal]

I do Wednesday and Saturday. Too lazy to perfectly do e3.5d or whatever

I started at 2 and titrated a little faster than I did on tirz, but still mostly in the 3-4 week per range.

The glucagon receptor activation is going to be a virgin response regardless of what dose you were on with tirz, and it can cause significant RHR increase. I wouldn't go too fast.

 

[TTRich]

I've been on Tirz 12.5 mg since Dec. 2024, I've lost 80 lbs. Insurance dropped all GLP1s, so I'm rotating into Reta to lose the last 50lbs. I've stalled on Tirz, despite higher protein intake (150g a day for a 200-pound female), lifting weights four days a week, cycling on off-weight days, logging, etc. I feel stronger from lifting, and there may be some conversion of fat to muscle, but the scale isn't moving.

I also really wonder about where my weight has settled. Two kids later, my weight is disproportionately concentrated in my hips and thighs. I'm two dress sizes larger in pants than in dresses or tops.

Questions -

I'm going to start at 2mg of Reta, but since I've been on a higher dose of Tirz for a while, I may increase it after the first two weeks. I'm going to listen to my body and play it by ear; I know it takes time to build up.

Half Life - What is the ideal half-life schedule? Do I dose every 5 days, or split up my dose, if 2mg total, 1mg on Sunday, and another on Wednesday?

Imo, dosing should be as the drug's clinical trial suggests. Every 7 days. There have been tests proving that splitting Reta doses is not optimal

 

[hexagonal]

Imo, dosing should be as the drug's clinical trial suggests. Every 7 days. There have been tests proving that splitting Reta doses is not optimal

Citation?

 

[Lifeworthliving]

I do Wednesday and Saturday. Too lazy to perfectly do e3.5d or whatever

I started at 2 and titrated a little faster than I did on tirz, but still mostly in the 3-4 week per range.

The glucagon receptor activation is going to be a virgin response regardless of what dose you were on with tirz, and it can cause significant RHR increase. I wouldn't go too fast.

This is something I need to keep in mind; just because I'm used to Tirz, RHR is brand new to me, I need to take care to let it build up slowly.

 

[zpped]

Citation?

Anecdotes. But there have been many people who started at split dosing and got better results after switching to roughly weekly. (I prefer 6 days)

I'm not saying it's proven, but it's plausible and not weird to have a certain responses only triggered at higher peak concentrations.

I've been on Tirz 12.5 mg since Dec. 2024, I've lost 80 lbs. Insurance dropped all GLP1s, so I'm rotating into Reta to lose the last 50lbs. I've stalled on Tirz, despite higher protein intake (150g a day for a 200-pound female), lifting weights four days a week, cycling on off-weight days, logging, etc. I feel stronger from lifting, and there may be some conversion of fat to muscle, but the scale isn't moving.

I also really wonder about where my weight has settled. Two kids later, my weight is disproportionately concentrated in my hips and thighs. I'm two dress sizes larger in pants than in dresses or tops.

Questions -

I'm going to start at 2mg of Reta, but since I've been on a higher dose of Tirz for a while, I may increase it after the first two weeks. I'm going to listen to my body and play it by ear; I know it takes time to build up.

Half Life - What is the ideal half-life schedule? Do I dose every 5 days, or split up my dose, if 2mg total, 1mg on Sunday, and another on Wednesday?

Don't be worried if you stall or even gain a bit of weight over the next couple months as you transition. Reta also feels different than tirz for most people. You'll feel more normal hunger signals which I feel is healthier to rebuilding a good relationship to eating.

It's going to take a whole month before the Tirz is mostly out of your system as well. By then you should be able to go up to 4mg on reta and start getting some of its effects.