Tirz to Reta - feedback pls

[Lifeworthliving]

I've been on Tirz 12.5 mg since Dec. 2024, I've lost 80 lbs. Insurance dropped all GLP1s, so I'm rotating into Reta to lose the last 50lbs. I've stalled on Tirz, despite higher protein intake (150g a day for a 200-pound female), lifting weights four days a week, cycling on off-weight days, logging, etc. I feel stronger from lifting, and there may be some conversion of fat to muscle, but the scale isn't moving.

I also really wonder about where my weight has settled. Two kids later, my weight is disproportionately concentrated in my hips and thighs. I'm two dress sizes larger in pants than in dresses or tops.

Questions -

I'm going to start at 2mg of Reta, but since I've been on a higher dose of Tirz for a while, I may increase it after the first two weeks. I'm going to listen to my body and play it by ear; I know it takes time to build up.

Half Life - What is the ideal half-life schedule? Do I dose every 5 days, or split up my dose, if 2mg total, 1mg on Sunday, and another on Wednesday?

 

[hexagonal]

I do Wednesday and Saturday. Too lazy to perfectly do e3.5d or whatever

I started at 2 and titrated a little faster than I did on tirz, but still mostly in the 3-4 week per range.

The glucagon receptor activation is going to be a virgin response regardless of what dose you were on with tirz, and it can cause significant RHR increase. I wouldn't go too fast.

 

[TTRich]

I've been on Tirz 12.5 mg since Dec. 2024, I've lost 80 lbs. Insurance dropped all GLP1s, so I'm rotating into Reta to lose the last 50lbs. I've stalled on Tirz, despite higher protein intake (150g a day for a 200-pound female), lifting weights four days a week, cycling on off-weight days, logging, etc. I feel stronger from lifting, and there may be some conversion of fat to muscle, but the scale isn't moving.

I also really wonder about where my weight has settled. Two kids later, my weight is disproportionately concentrated in my hips and thighs. I'm two dress sizes larger in pants than in dresses or tops.

Questions -

I'm going to start at 2mg of Reta, but since I've been on a higher dose of Tirz for a while, I may increase it after the first two weeks. I'm going to listen to my body and play it by ear; I know it takes time to build up.

Half Life - What is the ideal half-life schedule? Do I dose every 5 days, or split up my dose, if 2mg total, 1mg on Sunday, and another on Wednesday?

Imo, dosing should be as the drug's clinical trial suggests. Every 7 days. There have been tests proving that splitting Reta doses is not optimal

 

[hexagonal]

Imo, dosing should be as the drug's clinical trial suggests. Every 7 days. There have been tests proving that splitting Reta doses is not optimal

Citation?

 

[Lifeworthliving]

I do Wednesday and Saturday. Too lazy to perfectly do e3.5d or whatever

I started at 2 and titrated a little faster than I did on tirz, but still mostly in the 3-4 week per range.

The glucagon receptor activation is going to be a virgin response regardless of what dose you were on with tirz, and it can cause significant RHR increase. I wouldn't go too fast.

This is something I need to keep in mind; just because I'm used to Tirz, RHR is brand new to me, I need to take care to let it build up slowly.

 

[zpped]

Citation?

Anecdotes. But there have been many people who started at split dosing and got better results after switching to roughly weekly. (I prefer 6 days)

I'm not saying it's proven, but it's plausible and not weird to have a certain responses only triggered at higher peak concentrations.

I've been on Tirz 12.5 mg since Dec. 2024, I've lost 80 lbs. Insurance dropped all GLP1s, so I'm rotating into Reta to lose the last 50lbs. I've stalled on Tirz, despite higher protein intake (150g a day for a 200-pound female), lifting weights four days a week, cycling on off-weight days, logging, etc. I feel stronger from lifting, and there may be some conversion of fat to muscle, but the scale isn't moving.

I also really wonder about where my weight has settled. Two kids later, my weight is disproportionately concentrated in my hips and thighs. I'm two dress sizes larger in pants than in dresses or tops.

Questions -

I'm going to start at 2mg of Reta, but since I've been on a higher dose of Tirz for a while, I may increase it after the first two weeks. I'm going to listen to my body and play it by ear; I know it takes time to build up.

Half Life - What is the ideal half-life schedule? Do I dose every 5 days, or split up my dose, if 2mg total, 1mg on Sunday, and another on Wednesday?

Don't be worried if you stall or even gain a bit of weight over the next couple months as you transition. Reta also feels different than tirz for most people. You'll feel more normal hunger signals which I feel is healthier to rebuilding a good relationship to eating.

It's going to take a whole month before the Tirz is mostly out of your system as well. By then you should be able to go up to 4mg on reta and start getting some of its effects.

 

[hexagonal]

Anecdotes. But there have been many people who started at split dosing and got better results after switching to roughly weekly. (I prefer 6 days)

I'm not saying it's proven, but it's plausible and not weird to have a certain responses only triggered at higher peak concentrations.

Yeah, I've read the anecdotes. Personally, I've tried both when I was at lower dosages and seen no difference besides my RHR spiking more. Which raises the metabolism a bit, but... not much, and has other health concerns. (It spikes it too much now for me to even want to move from 5mg twice a week to 6mg, so single bolus is out of the question for me regardless.) Fairly controlled diet/workout schedule, but obviously single person anecdote, only so much I can control for, etc. Not comfortable making a definitive statement based on my personal experience there.

Mechanistically, it would be odd to me if an effect is triggered at 4mg once a week and not also triggered at 4mg or 5mg twice a week. There's of course some adaptation, but the current evidence seems to suggest that we don't see tachyphylaxis with GLP-1s. The receptors recycle frequently, and tirz/reta have been designed to minimize β-arrestin recruitment which seems to be the primary concern for desensitization of the receptors, if I understand the literature correctly. We don't have as much hard data for the glucagon receptor here and I suppose that being the primary difference could explain why it seems to be more of a thing with reta according to some anecdotes. But I've seen some of the same anecdotes talking about needing to take a re-sensitization break between swapping to reta, which would imply it's not just GCGR at issue. (Frankly, I don't think the evidence really supports the idea of needing to take re-sensitization breaks in general.) I suppose it could be other physiological changes rather than pharmalogical, but... lots of assumptions and guesses.


But we have minimal hard data here, so it's all conjecture, I think. Mostly reacting to the strongly worded "proven" and "tests" here. Pretty sure we have nothing but anecdotes. Which, enough of in lieu of any other evidence might be enough to convince me, a la what we see with some usage of AAS over decades of tens of thousands of users, but a handful of reports over a year, not so much.

 

[DoubleK]

Wow, 80 lbs is amazing! Huge congrats on pushing through that far, especially with two kids and the insurance drama. That kind of stall must be so frustrating, especially when you're clearly doing everything right with diet and lifting. I'm curious how the transition to Reta ends up feeling for you, especially hunger-wise.