Tirzepatide Possibilities??????

On tirz I lost about 2lbs a week, I was going to try for 185 but decided to go for normal BMI target of 163.

The one concern I have read about reta is potential heart rate issues so monitor that if you choose reta but it did better in the trials for total percentage.

Tirz did great for me with +/- 25% in 7 months

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I'm quite a bit older and started off a little heavier than you and Tirz has been AMAZING for me so far! I', 6'2" - 55yrs old and started at 386. I started on May 7th with .25 Triz and just moved to .50. I've lost 26lbs in only 5 weeks.

I haven't worked out one time and I sit at a desk working from home all day. I changed my diet drastically and it was extremely easy to do, I just don't crave the fried stuff anymore and I don't have snacks or ANY bad food in the house.

I only eat salads, raw veggies, tomatoe basil soup, mushroom bone broth soup, split pea soup, fresh fruit smoothies with almond milk, or fresh fruits, and almost no meat. I've had a small piece of meat on Sunday's a couple weeks--2-3 small turkey meatballs and a couple strips of skinless chicken breast. Otherwise, I've only eaten what was previously stated and unsalted nuts, protein/high fiber bars.

I added B12 2000mcg in the morning, 225mg of Magnesium Malate in the evening to sleep better, 20g of Collagen protein at lunch for joint and skin care, Casein in the early evening to slowly release protein as I rest and sleep. Whey protein will be added when I start working out as a pre-workout. I will start resistance training soon so I don't have tons of loose skin after the weight is gone. Goal is 215lbs.
 
I'm quite a bit older and started off a little heavier than you and Tirz has been AMAZING for me so far! I', 6'2" - 55yrs old and started at 386. I started on May 7th with .25 Triz and just moved to .50. I've lost 26lbs in only 5 weeks.

I haven't worked out one time and I sit at a desk working from home all day. I changed my diet drastically and it was extremely easy to do, I just don't crave the fried stuff anymore and I don't have snacks or ANY bad food in the house.

I only eat salads, raw veggies, tomatoe basil soup, mushroom bone broth soup, split pea soup, fresh fruit smoothies with almond milk, or fresh fruits, and almost no meat. I've had a small piece of meat on Sunday's a couple weeks--2-3 small turkey meatballs and a couple strips of skinless chicken breast. Otherwise, I've only eaten what was previously stated and unsalted nuts, protein/high fiber bars.

I added B12 2000mcg in the morning, 225mg of Magnesium Malate in the evening to sleep better, 20g of Collagen protein at lunch for joint and skin care, Casein in the early evening to slowly release protein as I rest and sleep. Whey protein will be added when I start working out as a pre-workout. I will start resistance training soon so I don't have tons of loose skin after the weight is gone. Goal is 215lbs.
Just a note since you mentioned protein as a pre-workout: the timing of your protein does not really matter throughout the day, only the total amount. Recent studies have come out showing that. If you need it to not be hungry during a workout that’s different, but in terms of impact on muscle, etc. timing doesn’t matter.
 
Soooo....For some background info: I am a 42 y/o Male, 6'2" and weigh 370 pounds. Over the span of 1 year on tirzepatide, what is a realistic estimate of how much weight I could lose? Currently I am pretty sedentary with a desk job, but I actually love to work out, so that wont be a problem. And I am in the middle of planning a realistic diet i can stick with. My big problem in the past has been going hard core with the workouts and cardio to the point where it is just not sustainable and then I give up. Help please!
I get probably 4-6K steps a day at my job, do not do much strength training, unfortunately. I was 237 and am around 200lb. I really didn’t make any lifestyle modifications and lost that weight in probably 2 months.

I have just been maintaining now at 7.5-12mg just depending on the food noise.

I think with lifestyle modification you can lose considerable amount of weight. All depends how you tolerate the drug. I think the biggest thing to watch is how fast you lost the weight. A lot of the long term issues that are being reported usually derive from rapid weight loss and the body not adjusting properly. That and malnutrition; so a multivitamin and other supplements would be beneficial.
 
I started tirzepatide in December 2024 at 335lbs (I'm 6'4") and by December 2025 I weighed about 244, so 91lbs or 27% less than my starting weight.

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Your starting weight is higher than I was, but if you take the 370lbs and multiply by 27%, you could easily lose about 100lbs in a year on tirzepatide.

BUT, I 100% agree with @woundcarping when he says to consider reta. If I had access to retatrutide in December 2024, I would have definitely done that rather than tirzepatide, and I love tirzepatide.
My only concern with reta is I hear the appetite reduction is nonexistent as well as the help with food noise....what's your experince? Great job on the weightloss!
 
Every person is different. Don’t limit yourself because of what others have done.

My starting weight was 445lbs. I’m 6’1” and 61 years old and now weigh 210lbs and falling. Lots of lifestyle changes and eating less. I started with sema then tirzepatide and recently reta.
 
Who they kidding? Not sure how 2.5 tirz will work but once you get to 5 and 7.5 youll find youd have to go out of your way to not lose 60lbs in 4 months....
 

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