I started the middle of May. I did 2 weeks of 2.5, then went to 5, and have stayed there. I recently switched to Sunday and Wednesday splitting. I'm not sure I feel different. I don't have that lovely appetite suppression I did the first few weeks, but I'm not going to chase that. I weigh daily, and without fail, (except last week on vacation, I gained a tenth of a pound) the number has been lower than the previous week. There is anecdotal evidence that people can build resistance. If you get to 15, and stop making progress, then what? I don't care to be in that situation. I hope to reach my goal before I max out the dose. It's hard to evaluate financially - if you spend more, but lose faster, is that the same as slow and steady and cheaper? I also am up there in age, and while my skin has always previously bounced back from 30-40 pound losses, this time I'm going for 80-90. So far, so good at a nice two pound a week rate. I'm close to halfway to goal, and have started to have hopes that my skin is going to be reasonably okay. All of which is not to say that on days when the scale dies not match my expectations, I don't feel like, okay that's it! Going to 7.5! (Actually I'd probably go to 6 because that odd number bugs the crap out of me!) But I tell myself, just see what it looks like on Sunday, do you weigh less than last Sunday, are your measurements smaller - and so far the answer has been yes.