Type 1 Diabetes

[DannyGreenfire]

Has Reta been tested at all on Type 1 diabetics? From what I’ve read and people I’ve spoken to it’s a little softer than Semaglutide but I can’t find any info on suitability for T1Ds. When it says Reta works on Insulin and Glucagon receptors does it do so in a way which might be detrimental for someone with T1D.

Do I have any choice if I want a degree of research backed safety - aside from Semaglutide?

 

[McFatty]

Because of the GLP1 agonist in these peps, I would be highly cautious in using these if at all with type 1 diabetes. Have you considered other peps to research that do not work on those glp1 receptors?

 

[DannyGreenfire]

What’s the reason they can’t be used with T1D though? What’s about the mechanism of how they work makes them unsuitable?

No, I haven’t looked into other non-GLP1s. What in particular are you thinking of? I’m not massively versed in weight loss peptides.

 

[McFatty]

It's based in keeo insulin low. People with type 1 have to inject insulin. It's similar to the idea that people with type 1 can't take metformin either. Maybe look into the peptide AOD, cjc1295 with Ipamorelin, tesamorelan, MOT-C.

 

[DannyGreenfire]

People with Type 1 can take Metformin and often do. They just have to take it alongside exogenous insulin. I’m not sure if the mechanism that keeps the bodies insulin production low would affect an exogenous insulin source anyway?

Either way, I’ll look into the others. Are there any that are seen as particularly effective?

 

[McFatty]

People with Type 1 can take Metformin and often do. They just have to take it alongside exogenous insulin. I’m not sure if the mechanism that keeps the bodies insulin production low would affect an exogenous insulin source anyway?

Either way, I’ll look into the others. Are there any that are seen as particularly effective?

Thanks for letting me know about metformin.

 

[cta7978]

People with Type 1 can take Metformin and often do. They just have to take it alongside exogenous insulin. I’m not sure if the mechanism that keeps the bodies insulin production low would affect an exogenous insulin source anyway?

Either way, I’ll look into the others. Are there any that are seen as particularly effective?

Not quite on topic, but exciting news a couple days ago, they appear to have essentially cured T1D, probably take 10 years to get to market.. but exciting stuff. https://www.fiercebiotech.com/biote...-transformative-cure-type-1-diabetes-analysts

 

[AndyPanda]

You should probably confirm this with Wilford Brimley, but it looks like Tirzepatide can be used with the Type 1 “Diabeetus.”

 

[Pipsko]

You should probably confirm this with Wilford Brimley, but it looks like Tirzepatide can be used with the Type 1 “Diabeetus.”

Yes, T1D myself and using Tirzepatide for two months now. But I am also on a DIY Loop (App on smartphone which controlls my insulin pump with an algorithm) which does most of the work.

Anyone with T1D, T2D, T3D or CGM has any experience how Retaturtide influences the blood glucose levels?

 

[hexagonal]

Yes, T1D myself and using Tirzepatide for two months now. But I am also on a DIY Loop (App on smartphone which controlls my insulin pump with an algorithm) which does most of the work.

Anyone with T1D, T2D, T3D or CGM has any experience how Retaturtide influences the blood glucose levels?

https://diabetesjournals.org/diabet...66-OR-Retatrutide-an-Agonist-of-GIP-GLP-1-and https://diabetes.org/newsroom/ameri...ype-2-diabetes-during-late-breaking-symposium have some details around insulin and hba1c levels but on a quick perusal I haven't seen data specifically on serum glucose levels

 

[Pipsko]

Thank you for posting those abstracts. I am trying to find out for myself how the Glucagon-Receptor is triggered by Retaturtide in what kind of "intensity". Gluconeogenisis in the liver triggered by glucagon is cool thing, because in order to refill up on glycogen fat might be used if nothing is available.

I compare that to my situation as a T1D after a night out drinking. 16-18hs after my first drink I have low glucose levels because my liver finished braking down the alcohol and is replenishing its reservours with glycogen.
In a healthy person Insulin secretion would halter o lowered by beta cells. But as a T1D I can´t do that as fast as normal ß-Cells. I use an ultra fast acting Insulin which kicks in within 20 minutes but does not fade out as fast, (4-6+hs), depending on my insulin sensitivity and cortisol levels.

I hope I made everything more complicated !

 

[cta7978]

Yes, T1D myself and using Tirzepatide for two months now. But I am also on a DIY Loop (App on smartphone which controlls my insulin pump with an algorithm) which does most of the work.

Anyone with T1D, T2D, T3D or CGM has any experience how Retaturtide influences the blood glucose levels?

You must be excited about Sana Biotechnology's recent developments? https://ir.sana.com/news-releases/n...gy-announces-positive-clinical-results-type-1