Weight Loss Peptide Comparison Table

[Dustycotton]

This might be helpful info for some who are currently researching the various peptides discussed here, so I have been working on a comparison table that condenses the info and allows for easier comparison. I put this together for my own use, with information that I wanted to compare. Do not use this info to make any decisions for your RS, because I am some rando on the internet. DO YOUR OWN RESEARCH. However, this may be helpful in pointing someone in the right direction with what words/phrases to search for while conducting your own research, especially if you are new to research in this area.

 

[MakeItaDouble]

This might be helpful info for some who are currently researching the various peptides discussed here, so I have been working on a comparison table that condenses the info and allows for easier comparison. I put this together for my own use, with information that I wanted to compare. Do not use this info to make any decisions for your RS, because I am some rando on the internet. DO YOUR OWN RESEARCH. However, this may be helpful in pointing someone in the right direction with what words/phrases to search for while conducting your own research, especially if you are new to research in this area.

Thank you for sharing. I've never seen all this info in one place. Some of your subjective ratings on appetite surprised me. A GREAT starting point for anyone starting THEIR OWN RESEARCH though.

 

[Drexeldragon216]

This is great info! Thanks for putting this together.

 

[Sackett]

Thanks @Dustycotton great educational resource. Amazing what is being developed.

 

[dionysos]

This might be helpful info for some who are currently researching the various peptides discussed here, so I have been working on a comparison table that condenses the info and allows for easier comparison. I put this together for my own use, with information that I wanted to compare. Do not use this info to make any decisions for your RS, because I am some rando on the internet. DO YOUR OWN RESEARCH. However, this may be helpful in pointing someone in the right direction with what words/phrases to search for while conducting your own research, especially if you are new to research in this area.

Your entries for "appetite suppression" are very different than my experience.
It seems to me that they also differ notably with impressions of the researchers themselves.
Dennis

 

[Tomes]

Your entries for "appetite suppression" are very different than my experience.
It seems to me that they also differ notably with impressions of the researchers themselves.
Dennis

Came here to say the same thing, @Dustycotton is this purely based on your own experience? Have you tried all these out? or is it based on what you've read in literature / trials?

Reta a 9 on appetite is a definite disagree for me, but could be all dose-dependent as well, as I've heard the suppression gets much better at higher doses.

 

[Dustycotton]

I scored based primarily on the known pharmacological effects/mechanism of each, and secondarily based on the published combined weight loss results and glycemic control (HbA1c reduction and managing blood glucose). Not based on trial participant self-reported outcomes.

 

[Dustycotton]

Your entries for "appetite suppression" are very different than my experience.
It seems to me that they also differ notably with impressions of the researchers themselves.
Dennis

Interesting. Would be interesting to read the specific published trial data the researchers impressions you saw are from for each of the drugs listed. I would like to review for any updates.

 

[Dustycotton]

Came here to say the same thing, @Dustycotton is this purely based on your own experience? Have you tried all these out? or is it based on what you've read in literature / trials?

Reta a 9 on appetite is a definite disagree for me, but could be all dose-dependent as well, as I've heard the suppression gets much better at higher doses.

It is definitely dose-dependent. In the Phase 2 trial results, participants in the higher-dose groups of 6mg and 12mg consistently reported feeling less hungry and more satisfied after meals. They also noted reduced food cravings, particularly for high-calorie foods, which directly correlated with the higher weight loss results for these groups. The lower-dose participants has some initial appetite supression, but it was not sustained or as pronounced as those that went up to the 6mg and 12mg doses over the 48 weeks.

 

[Davin8r]

Reta had 24% weight reduction in the phase 2 trial, not 17%. This is very important because it's the most effective GLP drug so far, besting tirz (21%).

 

[Bacchus]

Reta had 24% weight reduction in the phase 2 trial, not 17%. This is very important because it's the most effective GLP drug so far, besting tirz (21%).

Depends what time-frame you are looking at/if you only read headlines or read the entire text

https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal

 

[Davin8r]

Depends what time-frame you are looking at/if you only read headlines or read the entire text

Tirz showed mean 21% at 72 weeks, so it's not really fair to Retatrutide to show its mean as 17.5% at 24 weeks when it went all the way to 24% at 48 weeks. Also, the subjects were still losing weight so who knows what the number would have been if it had been extended out to 72 weeks?

 

[Bacchus]

Tirz showed mean 21% at 72 weeks, so it's not really fair to Retatrutide to show its mean as 17.5% at 24 weeks when it went all the way to 24% at 48 weeks. Also, the subjects were still losing weight so who knows what the number would have been if it had been extended out to 72 weeks?

I completely agree, but at the same time I don't really see the point of comparing trial results - Unless you dig deeper and make sure you are comparing apples with apples.

Personally I find reta to be vastly superior to both sema and tirz, but people are different.

I would still recommend anyone who asks, to start with Sema, move on to Tirz if Sema gives too much sides, then move on to Reta if Tirz doesn't suppress appetite enough or makes you lethargic.

Chasing the statistically "best" medication for max weight loss in a short timespan doesn't seem like a good starting point to me. But that's more of a personal opinion

 

[Davin8r]

Chasing the statistically "best" medication for max weight loss in a short timespan doesn't seem like a good starting point to me. But that's more of a personal opinion

Ok but this thread (and @Dustycotton 's chart) is literally about comparing the various weight loss peptides. If your point is to just burn this thread because none of it matters, then ok(?). I'm only suggesting to simply correct the table to say Reta caused mean weight loss of 24% at week 48, and that's all.

 

[Bacchus]

Ok but this thread (and @Dustycotton 's chart) is literally about comparing the various weight loss peptides. If your point is to just burn this thread because none of it matters, then ok(?). I'm only suggesting to simply correct the table to say Reta caused mean weight loss of 24% at week 48, and that's all.

Na, that was clearly side-tracking, you're right.

I'm just skeptical towards comparing numbers from studies in a table. It often ends up being apples to oranges since the studies aren't necessarily conducted in the same manner