What dose of reta are you at?

[Peptidesearch]

Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.

I prefer staying at the lowest effective dose until it loses effectiveness, only then would I move up.

 

[ntotheth]

Hello from the UK.

I've just started today at 2 mg. So wish me luck.

I've previously been on Mounjaro and reached 15mg, but the last dose was over a month ago.

It will be interesting to see how it feels.

I sourced a single vial from the UK supplier. (Obviously, I paid too much!), but depending on how it goes I'm looking at buying kits from China, like everybody else. I just want to check i get on ok with Reta, as may revert back to Tirz so didnt want to make a big order.

must admit, not noticing any effect from yesterday's 2mg of reta....

 

[390120]

must admit, not noticing any effect from yesterday's 2mg of reta....

I personally didn’t feel anything until I hit 4mg

 

[lessthanhalf]

This thread would be a lot more useful if people posted their start weight , goal weight and current weight . Interpreting what doses do what in different people has a lot to do with how much weight you are trying to lose and how much you have already lost.
I was already on 15mg of tirzepatide and trying to maintain a 54% weight loss. I saw a study showing 9% weight loss from only 1mg of reta over a year, which I thought was pretty amazing, none of the other GLP's are anywhere near that effective at really low doses, so I started adding reta to tirzepatide, currently on 5mg.
I think this result helps to explain the very wide range of doses of reta people are using.

 

[Nerker]

Update: Just finished week 6 of 2mg 1x weekly.
5'9", 52yo Male
I started at 208lb and am at 188.
20lb loss in 6 weeks.
No need to titrate up. Food noise (I ate ice cream, cashews and low fat mozz sticks at will) is 0% with these actors.

A note: for the last 5 years in January, I've locked into Whole eating with one cheat day and lost the same 20lb by April/May. Then I'd slowly fatigue from locking in and gain back.

I am accustomed and thrive in the eating right environment. It's nice to be here. No guilt.

I didn't think I had food noise but the thought of ice cream is non existent, feels "heavy" and "not worth it" when I think of it. No urge for cheat day or reward.

I will likely titrate down to microdose research after week 8, as my goal was to hit 175lb and I'll be close to that by week 8.

 

[Nerker]

must admit, not noticing any effect from yesterday's 2mg of reta....

I think on day 2 after first dose (2mg) I was at work and realized, "I really don't need to eat at all." And there was not a thought of my snacks during the the routine times I usually grazed. Miraculous shift in perspective.

 

[BNLFL]

My 3rd blast of 4mg Friday has really done a number on my appetite. I need find something different than beer, which I love. I've already knocked out about 80% of my old consumption. Went out for lunch around the corner, and was full at 2 wings and 3 beers. I'm supposed to make salmon and a salad, but no desire right now. I drink to much water I think, that also makes me full. Any opinions on the water deal?

 

[headward]

Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.

Thanks. I'm going to go down to maybe 2mg or so and intermittent water fast more, which is a lot easier with reta than without it. As is sticking to a meal plan/diet.

 

[lessthanhalf]

Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.

Tolerance to GLP medications is not really something that actually happens.
What people think is tolerance is usually the effect of weight loss, after a while of being on a dose of GLP you have lost weight , as you lose weight hunger goes up and metabolic rate goes down, so you stop losing weight and are a bit more hungry. But if weight is stable at that new point and not increasing, that is the drug doing its job, it has just done as much as it can in you at that dose.
If tolerance was real, and all the scientific studies say it is not , then people on these drugs for years would start gaining weight and every study says weight goes down for about a year then stabilises at that new lower weight and stays there for years ( I think 3-4 years is the longest follow up so far ). Assuming you continue on that dose.
Nearly everyone on these medications will get to a point where weight loss stops, hopefully this happens at a weight you are happy with, and at a dose that does not cause too many side effects, but how slow or fast the doses are increased , are not going to change where that point will be, that has more to do with genetics , lifestyle , exercise and diet, and the dose of reta you are on at the end. And to keep the weight off, that is the dose you are likely to need to stay on , assuming you are no longer losing weight at that point.
Whether staying on low doses as much as possible is a good idea , I think , depends on what you want from them. If you are younger and 10 kilos overweight good idea, average weight loss from 1mg of reta was nearly 9%.
If you have a BMI of over 35, and especially if you are older or have obesity related medical problems - metabolic syndrome , hypertension, heart disease, diabetes, high cholesterol etc. then I do not agree with the low dose approach. If you are losing weight at a rapid weight on a low dose, great there is no need to push the dose, or if side effects are a problem, but if you have a lot of weight to lose or weight loss slows or stops then increasing to the standard maximum dose of 12mg for reta is what you should be aiming for. It has been proven that higher doses are more effective than lower doses for preventing diabetes and heart disease, not for reta yet, but for semaglutide and tirzepatide, and though not proven yet it is very likely that this will also apply to reta. And obviously higher doses are more effective at causing weight loss, most recent longest term studies on reta show an average of 29% at 12mg which is amazing.

 

[ntotheth]

Hello from the UK.

I've just started today at 2 mg. So wish me luck.

I've previously been on Mounjaro and reached 15mg, but the last dose was over a month ago.

It will be interesting to see how it feels.

I sourced a single vial from the UK supplier. (Obviously, I paid too much!), but depending on how it goes I'm looking at buying kits from China, like everybody else. I just want to check i get on ok with Reta, as may revert back to Tirz so didnt want to make a big order.

2 mg, having no effect, so pinned another 2 mg after 3 days. I was on 12.5 mg of Mounjaro, so that's probably something to do with it. I still don't feel any effect now, however.

Anyway, I'll wait until next week, see how I feel.

Any advice from anybody coming from large doses of tirzepatide would be helpful.

I don't really want to go to 6 or 8 mg in week 1.

 

[woundcarping]

I don't really want to go to 6 or 8 mg in week 1.

Why? You were on 12.5mg of Tirz which I assume you stopped. Multiple small doses to get the Reta level up without a large bolus that could cause sides that you have to wait out.

I took 7mg of Reta in 6 shots my first week moving from a lower dose of tirz.

 

[Lyophilized]

I just upped my dose to 2 mg this morning after two weeks of 1 mg. For the record, I've been on Ozempic since February 2024 and took my last Ozempic jab last week.

So basically you were taking Reta plus Sema
How much mg of sema was your last shot?

 

[ntotheth]

Why? You were on 12.5mg of Tirz which I assume you stopped. Multiple small doses to get the Reta level up without a large bolus that could cause sides that you have to wait out.

I took 7mg of Reta in 6 shots my first week moving from a lower dose of tirz.

Thanks

Really helpful. I guess I just don't know really, and there's obviously lots of talk about people starting reta at 0.5 mg etc but I appreciate that's probably without any previous GLP-1 exposure.

I just felt that going straight to 6, 7 or 8 mg in the first week might be a bit much, but as you say, I was on 12.5 mg of tirzepatide.

 

[woundcarping]

Thanks

Really helpful. I guess I just don't know really, and there's obviously lots of talk about people starting reta at 0.5 mg etc but I appreciate that's probably without any previous GLP-1 exposure.

I just felt that going straight to 6, 7 or 8 mg in the first week might be a bit much, but as you say, I was on 12.5 mg of tirzepatide.

When you say no effect, what does that mean?

I agree the idea of starting Reta at a tiny dose isn’t for experienced GLP systems.

The y axis isn’t the same for the two compounds, my peak level on T was 5.6mg vs 10.9mg on Reta.

 

[ntotheth]

When you say no effect, what does that mean?

I agree the idea of starting Reta at a tiny dose isn’t for experienced GLP systems.

The y axis isn’t the same for the two compounds, my peak level on T was 5.6mg vs 10.9mg on Reta.

View attachment 16353

I suppose I mean when I don't feel anything, I don't feel any different to as if I hadn't taken any reta, no nausea, no suppression, nothing really.

But looking at my levels in the attached graph, I'm not quite at a peak yet, although the peak seems to be around just above 3 mg.

I have stopped Tirz completely so not stacking.

Would love to hear about the first couple of weeks on reta from people moving from 12.5 mg or 15 mg tirzepatide, and what levels people went in at and how they felt.

Thanks

 

[RubbaDubba1]

I started slow, like 0.5mg a week added to 5mg of Tirz and went up and down from there. After being off the Tirz completely, I got 4mg a week of Reta and lost 23 lbs in one month. Needless to stay, I don't see myself going any higher than that in the near future. I'm about 180lbs, with a BMI that's almost normal. I normally take 1mg of Tirz and Reta, keeps me compliant.

 

[onewalker]

So basically you were taking Reta plus Sema
How much mg of sema was your last shot?

I was at 0.75 mg/week of Semaglutide (actually brand name Ozempic), but my very last shot there wasn't enough left in the pen - so probably 0.5 mg for the last week.

 

[ntotheth]

View attachment 16357
I suppose I mean when I don't feel anything, I don't feel any different to as if I hadn't taken any reta, no nausea, no suppression, nothing really.

But looking at my levels in the attached graph, I'm not quite at a peak yet, although the peak seems to be around just above 3 mg.

I have stopped Tirz completely so not stacking.

Would love to hear about the first couple of weeks on reta from people moving from 12.5 mg or 15 mg tirzepatide, and what levels people went in at and how they felt.

Thanks

I should add for context that i am currently 240lb.

Was previously 360lb a year ago and lost 120lb using tirz (mounjaro) and ended up at 12.5mg. Stopped about a month ago but hunger came back pretty aggressively..... now moved to reta and seeing how 4mg goes and will try and stick on that for a few weeks.

Seems to take 2/3 days to work in my experience.

 

[Lyophilized]

I was at 0.75 mg/week of Semaglutide (actually brand name Ozempic), but my very last shot there wasn't enough left in the pen - so probably 0.5 mg for the last week.

Because Reta doesn't give so much hunger suppression I think a little bit of Sema will do the job.
And when I say a little bit I'm talking about 0.5mg like your last dose. With me it worked
So if you start to have more hunger /food noise....that's what I do to overcome

 

[Griffwisha]

I’ve been in maintenance for 10 months at 2mg. I’ve tried going down to 1mg, then tried 2mg every 2weeks, but settled into weekly dose at 2mg. I add cag every now then to quiet my mind.

 

[v2boi]

Started reta Jan 11 on 2mg weekly without fail. The plateau was when I was on holiday , took my weekly jab and also consuming a lot of food.

For context I’m approaching 50 skinny fat all my life. First GLP1 experience . Personal experience so far is it’s super impressive minimising muscle loss as I drop weight. Will be doing a lower maintenance dosage shortly just to keep some appeitte suppression and hopefully further body recomp.

 

[RoadRash]

What exactly is "skin sensitivity"... pain, itch, burning or?
Are the symptoms localized or wide spread?
Do they present as a rash or raised surface?

It's like having a very bad sunburn and i had it from my scalp to my feet, accompanied by aches and pains. Took two weeks to sort it itself out, I titrated my dose up too fast. Im back on track, its mostly passed, but it wasn't fun. What got me through it was knowing it was temporary and I was losing serious weight.

 

[Minkster]

I’ve been in maintenance for 10 months at 2mg. I’ve tried going down to 1mg, then tried 2mg every 2weeks, but settled into weekly dose at 2mg. I add cag every now then to quiet my mind.

What was your highest dose?

 

[RoadRash]

Thanks

Really helpful. I guess I just don't know really, and there's obviously lots of talk about people starting reta at 0.5 mg etc but I appreciate that's probably without any previous GLP-1 exposure.

I just felt that going straight to 6, 7 or 8 mg in the first week might be a bit much, but as you say, I was on 12.5 mg of tirzepatide.

I was on a relatively high dose of tirz (10mg) prior to tapering off because it got too expensive. I started on Reta a few weeks later and I quickly shot up to 4mg (2 weeks in) and immediately dealt with some pretty crappy sides like super sensitive skin (felt like a 2nd degree sunburn from head to toe) and joint achiness. I'm 90% past the sides now and will titrate up to 6mg in two weeks, but man the skin sensitivity was awful. I don't think it's a mistake to slow down a little bit, I wish I did. Even though they are both GLP1s, they sure hit different.

 

[Killswitch97]

I know everyone is different but I read a lot of posts where people start at low doses and don't need to titrate up that high of a dose.
I'm curious as to if people go all the way up to 12mg like in the clinical trials, if if they have reaped most benefits at lower doses.

So my question is:
How long have you been taking Reta for?
Where along are you in your journey?
What is your current dosage?

Week 7 here 3mg every 5 days. Thinking of adding 1mg tirz to help with the appetite suppression

 

[catdog]

For how long now? What are your stats?

Has been about 6 months at that dose. I started with tirzepatide and dosed it up to 15mg weekly. SW and HW: 215, Current weight: 152. I am stalled on reta 15mg (7.5 twice weekly), so thinking of uptitrating.

 

[Superduty67]

2nd month today, actually. Ran 1mg for 4 weeks, 3mg for 5 weeks, and just started 4mg a couple days ago after no weight loss in a few weeks. Hope I can stay here lol

 

[Fishcakes88]

Week 8, 5mg Reta, Pinning once every 6 days.

Thinking of jumping to 7.5mg after the next 5mg dose.

 

[Sid the SeaGull]

Week 8, 5mg Reta, Pinning once every 6 days.

Thinking of jumping to 7.5mg after the next 5mg dose.

Out of interest, what the reason for heading your dose above 6mg ? This is relatively fast compared to many others experience on the forum , however kinda in line with the trails .

I guess if your not loosing weight on a lower dose then head north .

 

[Fishcakes88]

Out of interest, what the reason for heading your dose above 6mg ? This is relatively fast compared to many others experience on the forum , however kinda in line with the trails .

I guess if your not loosing weight on a lower dose then head north .

I was on 15mg of Tirz(MJ) and when i switch to Reta and weightloss stall, but based on my recent blood test, my overall health markers improved way better, and slight muscle gain, no fat gain etc.

started at 2mg 1st week, then next to 4mg for 5 weeks, then been on 5 mg for 3 weeks, next pin is the 4th 5mg, and i have a 30mg vial so i thought maybe 7.5mg next as i did not experience any sides, appetite suppression started on 3rd week on 5mg.

Well based on feel i think, 7.5-8mg will have similar feel based on appetite suppression strength as 12.5-15mg of Tirz, of course its not a good way to gauge things. I need to lose another 14-16kg of fats to reach goal weight.