What dose of reta are you at?

I'm in week #4 of 2mg. Lost 11lbs in first 2 weeks and 2lbs week #3.
I'm was considering heading up to 4mg this Sat (dose day).

Food noise is less but I also lock down into eating right really well. I have an appetite but also wouldn't have to eat, if that makes sense.
I think phase #3 trial held the dose for 4 weeks before titrating up.
I've read that by week #4 I'm finally getting the max effect or steady state of the 2mg dose.

Should I do all 4 weeks on 2mg? Anyone have thoughts? I'm honestly excited for more aggressive weight loss but can be patient too.
 
Chili777 said:
8 mg in month 5. I'm still losing.
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Gr33dyOctopus said:
7mg tirz friday mornings, 5mg of reta monday mornings. I am NEVER actually hungry, and thats fine, cause i can always eat. 3 to 4 pounds dissolving off me every week.

Ive seen reta and tirz mixed in 1 or more vendors kits too, calling it a "burn blend" and holy fuck it works great.

I probably dont need as much as i take, but my sides are seriously minimal and my whole life is now about losing the weight asap.
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I was originally on 3mg / week or Tirz and my provider had me switch to 4mg / week of Reta. I have since titrated up to 6mg / week and after reading one of your previous posts have now added back in 2mg / week of Tirz. starting this week. I stalled on my weight loss ever since the switch to Reta, but it was during the holidays.
 
sealag53 said:
I was originally on 3mg / week or Tirz and my provider had me switch to 4mg / week of Reta. I have since titrated up to 6mg / week and after reading one of your previous posts have now added back in 2mg / week of Tirz. starting this week. I stalled on my weight loss ever since the switch to Reta, but it was during the holidays.
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Nice! Also, i should add that i often fast from 6pm sunday through 6pm tuesdays when I plateau. But stacking these two with fasting just destroys the fat
 
390120 said:
Im also on the more aggressive side since I didn’t get any sides even with max dose sema, I went up to 4mg pretty quickly. Curious, did you experience any sides at all with Reta?
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I did, but very very mild, i had constipation and gag reflex on my first 8mg pin, but it last and went away like a day or two and no more sides after that.
 
I'm keen to get an opinion from some of the longstanding or experienced members.

Seems that Reta is working well at lower doses than the trials , much lower .

I'm wondering if this is symptomatic that members here may be starting out at initial weights far lower than the manufacturer trials .

Thus a 350 pound starter may need the higher dose to have an effect , simply due to larger body mass . They may require up to 9-12mg

Thus someone starting at 200 pounds may not need that much and 2-4mg would have similar effects.

This seems reasonable, if starting weight was150 pounds I can't see that higher does would be needed simply by virtue of the lower body mass.

I'm new here this is just an observation from some of the experiences I've seen here . I could be totally wrong , and I'm happy to admit I make more mistakes than most .
 
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I took Reta 18 months ago weekly for about 5 months. I lost about 14kgs
I worked up slowly from 0.5mg to 2.5mg where I stayed most of my journey. Occasionally I took 3mg but it always made me feel awful so the following week I’d drop back to 2.5.

I tried splitting my dose up to twice a week and also used it weekly. I preferred weekly shots. Seems to pack more punch using it weekly.
 
Sid the SeaGull said:
I'm keen to get an opinion from some of the longstanding or experienced members.

Seems that Reta is working well at lower doses than the trials , much lower .

I'm wondering if this is symptomatic that members here may be starting out at initial weights far lower than the manufacturer trials .

Thus a 350 pound starter may need the higher dose to have an effect , simply due to larger body mass . They may require up to 9-12mg

Thus someone starting at 200 pounds may not need that much and 2-4mg would have similar effects.

This seems reasonable, if starting weight was150 pounds I can't see that higher does would be needed simply by virtue of the lower body mass.

I'm new here this is just an observation from some of the experiences I've seen here . I could be totally wrong , and I'm happy to admit I make more mistakes than most .
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My doctor, who is an expert for mounjaro said, that overweight people have much lower GLP1 in there System, than average gym bros. So they need much more.
 
I’m on week 33 and have just increased to 10mg per week. I also stack with Semaglutide (1mg) for additional food noise/appetite control. Reta on Tuesdays, Sema on Fridays for additional support going into the weekend. I’m a slow loser - 0.55 lb per week on average with 45-50 lbs more to go.

Sema seems to be getting harder to source from domestic warehouses, so starting to consider Cagri as a possible substitute.
 
Started reta at 2mg/week, split on Monday and Thursday mornings for 2 weeks. Increased to 4mg/week same split. My plan is to do this for 4 weeks, since that's when your residual amount plateaus. Not sure if I'll go to 6mg or 8mg.

I'm definitely noticing appetite suppression, and a complete reduction in food noise. I've seen about 2 lbs per week of weight loss, but I could definitely eat around that if I wanted to or if I wasn't working out. My hope is that with the next dose increase that I'll see some more of the weight loss without any other changes.
 
I just started today! 1mg today, and plan to do 1mg next Thursday as well.

So 1mg/week for two weeks. Then the plan is 2mg/week for four weeks which will take me through my very first test vial. After that we will have to see. 🙂
 
When I started my GLP journey in Jan of 2025 I was using compounded Tirz had no idea of Grey then. Starting weight 215 m. 5'9" 58 yr old one year later at target weight of 165
As time went by, I learned and educated myself on Grey and have a large supply of tirz. The rub is a lot of the weight I lost was muscle. I recently got some reta to see how it works
I would like to have been on it a year ago to see if the muscle loss issue would have went better
 
Sid the SeaGull said:
I'm keen to get an opinion from some of the longstanding or experienced members.

Seems that Reta is working well at lower doses than the trials , much lower .

I'm wondering if this is symptomatic that members here may be starting out at initial weights far lower than the manufacturer trials .

Thus a 350 pound starter may need the higher dose to have an effect , simply due to larger body mass . They may require up to 9-12mg

Thus someone starting at 200 pounds may not need that much and 2-4mg would have similar effects.

This seems reasonable, if starting weight was150 pounds I can't see that higher does would be needed simply by virtue of the lower body mass.

I'm new here this is just an observation from some of the experiences I've seen here . I could be totally wrong , and I'm happy to admit I make more mistakes than most i.
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Sid the SeaGull said:
Part of it is the starting BMI. I started at in January 2023 at 336 and lost naturally to 318. Started sema in July 2023 and Lost to 211 after reaching 3mg in July 2025. Slowly crept back up to 224 since mid 2025 to end of 2025. Now stacking 4mg Reta and 1mg sema at 218 and trying to battle the last 30 pounds off. Considering using Tesofensine in Reta does not work. The issue is most people reach a stasis even with weight loss surgery and it takes a lot to break it. I lost 30%+ of BMI which is considered excellent based on most research out there. Getting to 40%+ of BMI lost is really hard even using weight loss surgery and GLP-1 combined.
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5.5mg reta every 3 days, 1.25mg cagri every 3 days. Losing 0.23 lb/day, and 80lb total since July, putting me at 27.5 BMI now. I am down 147lb total from my peak in 2020.

The seven day dose equivalent for the reta is 5.5mg/3 days * 7 days/week = 12.8mg/week. However, since my 24mg reta vials are probably actually 30mg, multiply by (30/24) for my actual dose of 16mg/wk.

I keep a daily log, and have titrated up whenever my desire for sweets returns and weight loss slows. Given that I am maxed now on both reta and cagri, I may titrate down soon, over the period of one month, getting as low I can stand without significant weight gain, followed by another month at low dose, followed by titrating back up to whatever is the minimum effective dose.
 
Sid the SeaGull said:
I'm keen to get an opinion from some of the longstanding or experienced members.

Seems that Reta is working well at lower doses than the trials , much lower .

I'm wondering if this is symptomatic that members here may be starting out at initial weights far lower than the manufacturer trials .

Thus a 350 pound starter may need the higher dose to have an effect , simply due to larger body mass . They may require up to 9-12mg

Thus someone starting at 200 pounds may not need that much and 2-4mg would have similar effects.

This seems reasonable, if starting weight was150 pounds I can't see that higher does would be needed simply by virtue of the lower body mass.

I'm new here this is just an observation from some of the experiences I've seen here . I could be totally wrong , and I'm happy to admit I make more mistakes than most .
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I just finished 4 weeks at 2mg. Lost 16.8 lbs. No food noise and I can eat macros. I was tempted to go to 4mg but was feeling the 2mg well so stayed at 2mg.
I started at 209lbs and want to get to 170s.
I wondered about my size versus OG test subjects too. I would disappear at higher doses, I think.
 
Cut over from 15mg of Tirz. Titrated down over a month 12.5, 10, 6, 3, then 0. Started at 1mg for Reta, then 2, 3, 4. Currently this week I'm planning to stay at 4mg Reta and stack .5mg Cargi mid-week and see how that goes. So far, I've lost 5lbs this month after a stall on Tirz. Plan only to titrate up if I stall.

FYI - SW 295 in Nov 2024 when I started Tirz. Currently 216lbs. GW 190lbs. So, it's in sight!
 
Injected 2mg today, second week of my reta journey. My hunger already went down 2 days after I started on 1mg and I got full fast, although it I felt hunger coming back on the 5th day.

Today, hours after injecting my second dose, I felt full after eating half of a very small bowl of pasta. Also had to force feed myself a little bread with some cold cuts. Feeling pretty good other than that.

My husband also took his second dose today. He hasn’t felt any change, also doesn’t feel sick. He’s still very much hungry and can eat for the both of us now. I honestly seem to be responding extremely well to both Reta and CU. The latter doesn’t even sting or burn for me.
 
TRS123 said:
When I started my GLP journey in Jan of 2025 I was using compounded Tirz had no idea of Grey then. Starting weight 215 m. 5'9" 58 yr old one year later at target weight of 165
The rub is a lot of the weight I lost was muscle.
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Hey, TRS123. I'm in week 5 of 2mg. 52yrs, same height and 210lb for starting weight. How did you know you lost muscle. I'm obviously cautious about not losing muscle but I'm not "muscle-y". I don't body build. I have muscle from a life of physical work (truck loading/ live event install and tear down).
I should say that I'm rocking the high protein /low carb with whole foods and protein shakes.

I walk daily, do yoga in the mornings and do leg strengthening that my PT has me on.
Should I do more resistance? I'm open to it for sure. The yoga, for me, is a lot of push up style moves and position holding where I feel the burn.

A question to the group, how would I track subtle muscle loss?
 
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I take .5mg every 5 days which averages out to 0.7mg a week but not exact with half lives and the such.

36 y/o male started at 218 down to 203 currently 1 month in. 26% bf down to 23 current
 
Did two weeks of 2mg/week. Currently at 4mg / week, split 2mg on Mondays and Thursdays. I'll do that for 4 weeks total, then titrate up to 6mg for 4 weeks, then 8.
 
Nerker said:
Hey, TRS123. I'm in week 5 of 2mg. 52yrs, same height and 210lb for starting weight. How did you know you lost muscle. I'm obviously cautious about not losing muscle but I'm not "muscle-y". I don't body build. I have muscle from a life of physical work (truck loading/ live event install and tear down).
I should say that I'm rocking the high protein /low carb with whole foods and protein shakes.

I walk daily, do yoga in the mornings and do leg strengthening that my PT has me on.
Should I do more resistance? I'm open to it for sure. The yoga, for me, is a lot of push up style moves and position holding where I feel the burn.

A question to the group, how would I track subtle muscle loss?
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The fact that it is subtle loss of muscle makes it hard to recognize it is happening. I was never muscle-y either but average strength from physical work. After a year I know I’m not as strong when I working and my thigh muscle get stained quickly when carry things up a set of steps. My arm strength and muscle mass is down quite a bit
My suggestion is slow down the amount of weight you loose per month. I was dropping several pounds a week early on
 
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