Started at 1mg about 5 months ago, went for 3 weeks and upped it to 2mg went for another 3 weeks, lost about 20 lbs, then tried to go to 3mg, but the nausea was too much so I brought it back to 2mg. Not only was there nausea on the 3mg, but lethargy, lack of energy, but they say that's to be expected while the body converts from burning carbs to oxidizing fat. Takes a couple of weeks to get past that.
After a week back at 2mg, I started to get a strange cough, so I dropped it for about a month to make sure it wasn't related to the Reta.
Started back up about 3 weeks ago, back to 1mg, yesterday's dose was 1.5 mg, thinking I'll be at this dose for a while, for maintenance. I didn't need to drop much weight, but the other benefits of Reta were very enticing, not to mention that I bought 3 vials of 24 mg, so I plan to use it all.
I did notice some muscle loss, but I'm considering taking some HMB to prevent any more loss. Hard to keep up on the protein, I'm 6' 200lbs, so 200mg is difficult to hit. That, and the slower motility of the gut is problematic, as far as keeping things moving in the gut, added psyllium fiber early on to help with that, but it tastes terrible. May try the orange flavored Metamucil to make it go down easier. No sides from the 1.5 mg dose.