What is MOTS-c like?

[Straffer]

I've been reading up on MOTS-c and it seems quite promising, although some of the claims seem to be really out there.

Does it affect gym performance in a noticeable way? Can it help with losing fat while maintaining (or even gaining) muscle? Animal and human clinical trials often use significantly large dosages.

I'm curious about your perspectives.

 

[redbullwings]

I’m currently running my second cycle of MOTS-c after a long break. I take 5 mg around 3x per week, usually about 30 minutes before training. I lift 5x per week and do cardio after every session.

For me it’s not a stim or a massive “rush,” but more of a clean, steady energy boost. There’s no jitters, no crash. I feel less lethargic going into workouts and can push myself a bit harder and stay focused longer, especially with the cardio after. It gives my sessions a subtle extra oomph rather than anything dramatic. But I prefer that

I wouldn’t call it a magic fat-loss compound on its own—especially since I’m on Reta and that’s doing a lot of the heavy lifting in terms of scale weight. That said, MOTS-c is often mentioned as complementary to Reta <3

From my experience, it seems to improve training quality and tolerance, which over time can help body recomposition if diet and programming are dialed in.

 

[ftv10hb]

I’m currently running my second cycle of MOTS-c after a long break. I take 5 mg around 3x per week, usually about 30 minutes before training. I lift 5x per week and do cardio after every session.

For me it’s not a stim or a massive “rush,” but more of a clean, steady energy boost. There’s no jitters, no crash. I feel less lethargic going into workouts and can push myself a bit harder and stay focused longer, especially with the cardio after. It gives my sessions a subtle extra oomph rather than anything dramatic. But I prefer that

I wouldn’t call it a magic fat-loss compound on its own—especially since I’m on Reta and that’s doing a lot of the heavy lifting in terms of scale weight. That said, MOTS-c is often mentioned as complementary to Reta <3

From my experience, it seems to improve training quality and tolerance, which over time can help body recomposition if diet and programming are dialed in.

I'm planning to start MOTS-C in the somewhat near future to go with my Reta, did you start at 5mg 3x/week or did you start with a smaller dose initially?

 

[redbullwings]

I'm planning to start MOTS-C in the somewhat near future to go with my Reta, did you start at 5mg 3x/week or did you start with a smaller dose initially?

Honestly the dosing is kind of all over the place from what I found. Most anecdotal protocols seem to sit around 1mg or even less a few times a week, but there are also a lot of people running anywhere from 5–15 mg weekly, so there’s no real consensus. My first run I stayed conservative at 1 mg 3x/week just to assess tolerance.

This second cycle I decided to take a bit of a plunge and run it higher—about 15 mg total per week—mainly because I’m an insulin-resistance girly and wanted to really lean into the insulin sensitivity/metabolic effects, especially stacked with Reta. The only downside is I’m burning through the vials like crazy.

I’m keeping it to a short 4-week pulse because MOTS-C acts more like a mitochondrial signaling peptide (a hormetic stress signal), and the limited human/animal data we have suggests it may work best as a short-term metabolic signal rather than chronic exposure, so longer runs may not add much and could potentially blunt the effect.

 

[WeezinDaJuice]

I’m currently running my second cycle of MOTS-c after a long break. I take 5 mg around 3x per week, usually about 30 minutes before training. I lift 5x per week and do cardio after every session.

For me it’s not a stim or a massive “rush,” but more of a clean, steady energy boost. There’s no jitters, no crash. I feel less lethargic going into workouts and can push myself a bit harder and stay focused longer, especially with the cardio after. It gives my sessions a subtle extra oomph rather than anything dramatic. But I prefer that

I wouldn’t call it a magic fat-loss compound on its own—especially since I’m on Reta and that’s doing a lot of the heavy lifting in terms of scale weight. That said, MOTS-c is often mentioned as complementary to Reta <3

From my experience, it seems to improve training quality and tolerance, which over time can help body recomposition if diet and programming are dialed in.

Since you're a lifter, have you ever tried Nitric Oxide supplements (L-Arginine & L-Citrulline) and how did MOTS-C compare, if at all. Thanks.

 

[redbullwings]

Since you're a lifter, have you ever tried Nitric Oxide supplements (L-Arginine & L-Citrulline) and how did MOTS-C compare, if at all. Thanks.

I haven’t heard of L-Arginine & L-Citrulline nor tried them. Did a basic google search, they seem interesting. Tell me more about them