What strange side effects have you experienced?

[slowsixstang]

Title says it all, we all know about nausea and acid reflux, but what have you experienced with Tirz that may not be an "official" side effect, but you swear came from it?

I myself noticed increased nasal drainage from about week 2 on, and am now experiencing some lymph node swelling in my left jaw area. Seems others have experienced this too based on a Reddit search, but there isn't much talk of side effects here. I could just be getting sick, who knows. Keeping an eye on it.

 

[mintyquinn]

I've had some eye things happening, mainly feeling like my eyes are really dry or vision is blurry sometimes. I also have had a constant eye twitch under my left eye that seemed to get worse after I started sema - I switched to tirz as of two weeks ago and the twitch still happens but its less now? not sure if lack of sleep or glp1 was the issue.

 

[InvisibleActual]

I've had some eye things happening, mainly feeling like my eyes are really dry or vision is blurry sometimes. I also have had a constant eye twitch under my left eye that seemed to get worse after I started sema - I switched to tirz as of two weeks ago and the twitch still happens but its less now? not sure if lack of sleep or glp1 was the issue.

I have read of a few incidents of eye issues on Tirz, a recent study however concluded that it was not possible to link them together and in my opinion the study is incredibly weak. That's just to say eye issues are not entirely unheard of on GLP-1 meds but seem to be getting investigated. Too early to tell and that goes with all side effects if I'm being honest, the meds are just way too new to know anything concrete/long term.

2025 Study

Personally touch wood no side effects to speak of. I have friends who are on Tirz who talk of fatigue and lack of energy, and one who has stomach pains for only 1 day after injecting but I truly believe both of those things are due to a lack of good nutritional choices while on the medication.

 

[slowsixstang]

I've had some eye things happening, mainly feeling like my eyes are really dry or vision is blurry sometimes. I also have had a constant eye twitch under my left eye that seemed to get worse after I started sema - I switched to tirz as of two weeks ago and the twitch still happens but its less now? not sure if lack of sleep or glp1 was the issue.

Dry eyes related to dehydration seems to be super common, and eye twitching can be caused by that as well. Keep up on electrolytes and water and it should improve.

 

[Calm Logic]

And staring at your phone, searching for refills 😉

 

[Lucas]

I’m one of those lucky ones who barely had any side effects, just some occasional constipation. The biggest change for me has been mental - my mind feels way quieter on Mounjaro. Never had a mental health diagnosis or anything, but I just feel super calm. No anxiety, and the little stuff doesn’t bug me like it used to.

 

[vewdew34]

By biggest side affect right now is that I struggle to eat, looking at food its like looking at a piece of cardboard.
My appetite is gone, at 2.5mg and even 5mg I used to eat now at 7.5mg I cant even look at food. But I wont quit.

 

[Calm Logic]

I'm loving 6 mg of tirz right now. Hopefully I can lose weight still on it. But no more fatigue, diarrhea, or having to remind myself to drink fluids. Will raise it 0.5 mg each week until the sides come back. But I don't think I can do 10 mg again for long.

 

[mintyquinn]

Dry eyes related to dehydration seems to be super common, and eye twitching can be caused by that as well. Keep up on electrolytes and water and it should improve.

this is what i suspect is the issue - I've been trying to be more hydrated but could do better. My doctor said the eye twitch is also common if you lack proper sleep which could very well be an issue LOL. My sleep kinda sucks sometimes. (Not related to glp1 though, i just hate sleeping)

 

[lessthanhalf]

Louder tinnitus from tirzepatide, with both the prescribed expensive version and the cheaper one from china, I have had tinnitus for a long time and basically ignore it, but I thought it was a pretty weird drug side effect, otherwise much better than semaglutide which caused horrible nausea. Apparently a few other people have posted on reddit that they also had this effect.

 

[Calm Logic]

Rapid weight loss can also cause temporary issues by inducing "proprioceptive recalibration demands, further compromising vestibular adaptation":

The Risk of Vestibular Disorders with Semaglutide and Tirzepatide: Findings from a Large Real-World Cohort - PMC

Background/Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of type 2 diabetes and obesity. While their metabolic benefits are well-established, their potential effects on vestibular function remain ...

pmc.ncbi.nlm.nih.gov

GLP-1RA therapy is associated with an increased risk of vestibular disorders, with a higher risk observed with semaglutide compared to tirzepatide. These findings suggest the need for vestibular symptom monitoring in patients receiving these medications and warrant further investigation into underlying mechanisms...

The increased risk of vestibular disorders linked to GLP-1RAs may involve multiple interconnected pathways. First, direct modulation of vestibular processing may occur through GLP-1 receptors expressed in the brainstem (vestibular nuclei complex) and cerebellum, which are critical regions for balance regulation [27], potentially altering vestibulo-ocular reflex gain [28,29]. Second, fluid homeostasis disruption in the inner ear could arise from GLP-1RA-induced vasodilation (nitric oxide-dependent) and dysregulation of ion transport (Na+/K+-ATPase, aquaporins) [30], destabilizing endolymph composition in semicircular canals and otolith organs [31]. Third, metabolic stress in vestibular hair cells—highly dependent on mitochondrial bioenergetics—may be exacerbated by GLP-1RA effects on calcium handling and oxidative balance, particularly in patients with diabetes [32]. Fourth, autonomic interactions are suggested by baroreflex modulation via nucleus tractus solitarius GLP-1 receptors, which may impair postural compensation [33]. At the same time, tirzepatide’s reduced risk profile (HR = 3.19–4.55 vs. semaglutide HR = 4.02–4.95) implies that GIP co-activation mitigates sympathetic overdrive [34]. Finally, rapid weight loss may induce proprioceptive recalibration demands, further compromising vestibular adaptation [31] (Figure 5).

 

[jelder]

Has anyone had no effects from taking tirzepatide? I am only 2 weeks in, on a 2.5mg dose. I'm about 140lbs and thought I'd lose maybe a pound, but not at this point. I ordered from skye peptides if that makes a difference. Nothing seems different, so fortunately no side effects either. I having burning mouth syndrome, which comes and goes, and it is currently gone. I'm hoping there's a connection, but it's so hard to tell. I'm taking for pain relief, which for most happens at the lower doses.

 

[juGGaKNot]

I noticed a bump on my leg. It goes away from time to time. Feels like liquid.

nausea and acid reflux only if i overeat but i do a water fast the following day because of the feeling so calories even out.

 

[Chelsea_Dagger]

Has anyone had no effects from taking tirzepatide? I am only 2 weeks in, on a 2.5mg dose. I'm about 140lbs and thought I'd lose maybe a pound, but not at this point. I ordered from skye peptides if that makes a difference. Nothing seems different, so fortunately no side effects either. I having burning mouth syndrome, which comes and goes, and it is currently gone. I'm hoping there's a connection, but it's so hard to tell. I'm taking for pain relief, which for most happens at the lower doses.

I never felt anything (benefit or side effect) at 2.5mg, I don’t notice anything until 5. I just restarted after being off for over a year and am on 2.5 but am going to go up to 5 after 2 weeks instead of a month. I had restarted before and went straight to 5 without any issues.

One of the side effects I notice is that I’m always cold. Also, I don’t ever feel like drinking alcohol on tirz, and if I do drink I don’t feel like I get a buzz or any positive effect from it. So I just don’t.