What to do? 7mg split dose trz and then 7 reta every 3.5 days

[Gr33dyOctopus]

Thats what my current roll is. I am maintaining for the last month and a half 214 to 219 but kind of stalled. 215 and change today, but a month and a half ago I was 213.

Somehow, after a month off the glp1s I've managed to hold my weight down but now 3 shots in still hungry unfortunately. Time to make a move.

Want to reach Onederland at the least and 190 at the most to see how I feel there.

My current dosing is the title. Do I titrate up on the tirz or reta? Add cagri? Not really sure where to go for some reason i have 15 in my head as the limit but I know its not.

I can even reconstitute tirz at 30mg/ml and we decided we can do that with reta as well, right? Increase concentration to make the shooting amounts smaller.

So bummed to be building a tolerance but I need to keep bumping up if I need to so close to goal. Advice welcomed.

I know my avenues to stroll down to fix this just need help to choose the best one.

 

[eidos]

All I can tell you is that I'm on 7.5 mg/week of Tirz and 10 mg/week of Reta (I just lowered the Tirz dose from 10 mg). It's usually Tuesday and Friday. I've tried shorter intervals, but it's too complicated and doesn't make a difference.

The half-lives given are averages. There's no need to worry about half-day differences. Adjust based on your actual side effects and when you start feeling hungry again.
For Reta, one of the first Phase 1 studies showed that the half-life increased with dose. The reported average is 144 hours, but in practice, the range for 95% of patients is 6 to 8 days.

Receptor saturation occurs when doses are administered too close together because the amount in the body fluctuates less. You can create a pulse by spacing out the injections more.

 

[Gr33dyOctopus]

All I can tell you is that I'm on 7.5 mg/week of Tirz and 10 mg/week of Reta (I just lowered the Tirz dose from 10 mg). It's usually Tuesday and Friday. I've tried shorter intervals, but it's too complicated and doesn't make a difference.

The half-lives given are averages. There's no need to worry about half-day differences. Adjust based on your actual side effects and when you start feeling hungry again.
For Reta, one of the first Phase 1 studies showed that the half-life increased with dose. The reported average is 144 hours, but in practice, the range for 95% of patients is 6 to 8 days.

Receptor saturation occurs when doses are administered too close together because the amount in the body fluctuates less. You can create a pulse by spacing out the injections more.

Ty, pinning on Friday mornings and Monday mornings currently. Going up a couple mg on reta sounds good, that would put me right about your same dosing!

 

[woundcarping]

My current dosing is the title. Do I titrate up on the tirz or reta? Add cagri? Not really sure where to go for some reason i have 15 in my head as the limit but I know its not...

It's kinda up to you and your sides and preferences.

I take 9mg of Reta Monday night and Friday morning.

Last Thursday I pinned .25mg of Sema, today I pinned another .125mg. We'll see where that goes, .25mg was more than I wanted. I may prefer Tirz, Cagri, or Elora... don't have Elora on hand so far.

I'm around 217lb, got around 30lb to go to my high side target I think.

 

[Gr33dyOctopus]

It's kinda up to you and your sides and preferences.

I take 9mg of Reta Monday night and Friday morning.

Last Thursday I pinned .25mg of Sema, today I pinned another .125mg. We'll see where that goes, .25mg was more than I wanted. I may prefer Tirz, Cagri, or Elora... don't have Elora on hand so far.

I'm around 217lb, got around 30lb to go to my high side target I think.

Ya, you and I are around the same weight now, and looking to lose about the same amount of weight. I have yet to try sema or cagri. Meaning to buy cagri but looking for a us vendor that has that and bb5 or bb10 so I can just pick them up together.

Plus, I've heard cagri is exhausting and makes you tired. I just cant do that, my job is high energy and its a miserable time in hell to try to do it hung over on pills, booze or anything else.

Definitely wanna try elora but even in the group buys its nearly 2 bucks a mg, nah on that.

Probably up my tirz since that might possibly help the hunger. Tbh reta has been pretty good on hunger too when I titrate up.

 

[TacoLifter420]

Are the current doses of reta and tirz keeping your hunger in check? Do you know your current measured caloric intake? How many steps and how much other exercise?

That will give us a clearer picture on what levers to pull to get through this stall.

 

[Gr33dyOctopus]

Are the current doses of reta and tirz keeping your hunger in check? Do you know your current measured caloric intake? How many steps and how much other exercise?

That will give us a clearer picture on what levers to pull to get through this stall.

Fair enough. Im not counting calories, but i am digging into snacks at work now such as chips and mini candy bars. I wasnt doing that for about 9 months. Now I am, plus I've added some Costco trail mix bags to the mix.

Previously I was fasting 16 hours and eating in an 8 hour window and the weight came off regularly.

At home still mainly eating grilled meats and veggies but dreaming of pizza and sub sanddwiches.

Work is busy, I lead 1 to 2 exercise groups with weights bands and balls across a couple of buildings. And get in 6k steps or more by noon each day, usually end with 8 to 10k by end of work day. Arms and legs are pretty ripped, smaller than id like but pretty muscular.

Belly belly belly always been my problem. Shaped like a fucking potato. Had to stop glp1s for a month due to medical shit and just started back up on the 11th.

 

[lessthanhalf]

I really hope this is not an example of the rat study where they stopped and started semaglutide and those rats put on weight in between and progressively ended up losing less weight each time they went back on the GLP drug. It does sound like the same dose is being less effective at appetite suppression than it was before stopping it for a month.

I did think of a possible cause, Assuming you restarted at the same or similar dose rather than at a lower dose and built up, you will have much lower blood levels than steady state ( about half ) as it will take 4 weeks on that dose to get back to steady state levels. This could easily be enough to explain what you are experiencing and in theory the problem should sort itself out by the 4th dose/week. But you could put your doses into glp plotter and see when you get to consistent blood levels. If you only restarted on the 11th, this does make sense as a cause.