What to do? 7mg split dose trz and then 7 reta every 3.5 days

[Gr33dyOctopus]

Thats what my current roll is. I am maintaining for the last month and a half 214 to 219 but kind of stalled. 215 and change today, but a month and a half ago I was 213.

Somehow, after a month off the glp1s I've managed to hold my weight down but now 3 shots in still hungry unfortunately. Time to make a move.

Want to reach Onederland at the least and 190 at the most to see how I feel there.

My current dosing is the title. Do I titrate up on the tirz or reta? Add cagri? Not really sure where to go for some reason i have 15 in my head as the limit but I know its not.

I can even reconstitute tirz at 30mg/ml and we decided we can do that with reta as well, right? Increase concentration to make the shooting amounts smaller.

So bummed to be building a tolerance but I need to keep bumping up if I need to so close to goal. Advice welcomed.

I know my avenues to stroll down to fix this just need help to choose the best one.

 

[eidos]

All I can tell you is that I'm on 7.5 mg/week of Tirz and 10 mg/week of Reta (I just lowered the Tirz dose from 10 mg). It's usually Tuesday and Friday. I've tried shorter intervals, but it's too complicated and doesn't make a difference.

The half-lives given are averages. There's no need to worry about half-day differences. Adjust based on your actual side effects and when you start feeling hungry again.
For Reta, one of the first Phase 1 studies showed that the half-life increased with dose. The reported average is 144 hours, but in practice, the range for 95% of patients is 6 to 8 days.

Receptor saturation occurs when doses are administered too close together because the amount in the body fluctuates less. You can create a pulse by spacing out the injections more.

 

[Gr33dyOctopus]

All I can tell you is that I'm on 7.5 mg/week of Tirz and 10 mg/week of Reta (I just lowered the Tirz dose from 10 mg). It's usually Tuesday and Friday. I've tried shorter intervals, but it's too complicated and doesn't make a difference.

The half-lives given are averages. There's no need to worry about half-day differences. Adjust based on your actual side effects and when you start feeling hungry again.
For Reta, one of the first Phase 1 studies showed that the half-life increased with dose. The reported average is 144 hours, but in practice, the range for 95% of patients is 6 to 8 days.

Receptor saturation occurs when doses are administered too close together because the amount in the body fluctuates less. You can create a pulse by spacing out the injections more.

Ty, pinning on Friday mornings and Monday mornings currently. Going up a couple mg on reta sounds good, that would put me right about your same dosing!

 

[woundcarping]

My current dosing is the title. Do I titrate up on the tirz or reta? Add cagri? Not really sure where to go for some reason i have 15 in my head as the limit but I know its not...

It's kinda up to you and your sides and preferences.

I take 9mg of Reta Monday night and Friday morning.

Last Thursday I pinned .25mg of Sema, today I pinned another .125mg. We'll see where that goes, .25mg was more than I wanted. I may prefer Tirz, Cagri, or Elora... don't have Elora on hand so far.

I'm around 217lb, got around 30lb to go to my high side target I think.

 

[Gr33dyOctopus]

It's kinda up to you and your sides and preferences.

I take 9mg of Reta Monday night and Friday morning.

Last Thursday I pinned .25mg of Sema, today I pinned another .125mg. We'll see where that goes, .25mg was more than I wanted. I may prefer Tirz, Cagri, or Elora... don't have Elora on hand so far.

I'm around 217lb, got around 30lb to go to my high side target I think.

Ya, you and I are around the same weight now, and looking to lose about the same amount of weight. I have yet to try sema or cagri. Meaning to buy cagri but looking for a us vendor that has that and bb5 or bb10 so I can just pick them up together.

Plus, I've heard cagri is exhausting and makes you tired. I just cant do that, my job is high energy and its a miserable time in hell to try to do it hung over on pills, booze or anything else.

Definitely wanna try elora but even in the group buys its nearly 2 bucks a mg, nah on that.

Probably up my tirz since that might possibly help the hunger. Tbh reta has been pretty good on hunger too when I titrate up.

 

[TacoLifter420]

Are the current doses of reta and tirz keeping your hunger in check? Do you know your current measured caloric intake? How many steps and how much other exercise?

That will give us a clearer picture on what levers to pull to get through this stall.

 

[Gr33dyOctopus]

Are the current doses of reta and tirz keeping your hunger in check? Do you know your current measured caloric intake? How many steps and how much other exercise?

That will give us a clearer picture on what levers to pull to get through this stall.

Fair enough. Im not counting calories, but i am digging into snacks at work now such as chips and mini candy bars. I wasnt doing that for about 9 months. Now I am, plus I've added some Costco trail mix bags to the mix.

Previously I was fasting 16 hours and eating in an 8 hour window and the weight came off regularly.

At home still mainly eating grilled meats and veggies but dreaming of pizza and sub sanddwiches.

Work is busy, I lead 1 to 2 exercise groups with weights bands and balls across a couple of buildings. And get in 6k steps or more by noon each day, usually end with 8 to 10k by end of work day. Arms and legs are pretty ripped, smaller than id like but pretty muscular.

Belly belly belly always been my problem. Shaped like a fucking potato. Had to stop glp1s for a month due to medical shit and just started back up on the 11th.

 

[lessthanhalf]

I really hope this is not an example of the rat study where they stopped and started semaglutide and those rats put on weight in between and progressively ended up losing less weight each time they went back on the GLP drug. It does sound like the same dose is being less effective at appetite suppression than it was before stopping it for a month.

I did think of a possible cause, Assuming you restarted at the same or similar dose rather than at a lower dose and built up, you will have much lower blood levels than steady state ( about half ) as it will take 4 weeks on that dose to get back to steady state levels. This could easily be enough to explain what you are experiencing and in theory the problem should sort itself out by the 4th dose/week. But you could put your doses into glp plotter and see when you get to consistent blood levels. If you only restarted on the 11th, this does make sense as a cause.

 

[birdwhacker]

Fair enough. Im not counting calories, but i am digging into snacks at work now such as chips and mini candy bars. I wasnt doing that for about 9 months. Now I am, plus I've added some Costco trail mix bags to the mix.

Buddy... You gotta count the calories. It's not optional. You got the easy weight off, now you have to lock in.

Congratulations on the loss!

And as far as stacking is concerned, I gotta say go up on the reta until you get sides or you find the dose to be effective

 

[TacoLifter420]

Fair enough. Im not counting calories, but i am digging into snacks at work now such as chips and mini candy bars. I wasnt doing that for about 9 months. Now I am, plus I've added some Costco trail mix bags to the mix.

Previously I was fasting 16 hours and eating in an 8 hour window and the weight came off regularly.

At home still mainly eating grilled meats and veggies but dreaming of pizza and sub sanddwiches.

Work is busy, I lead 1 to 2 exercise groups with weights bands and balls across a couple of buildings. And get in 6k steps or more by noon each day, usually end with 8 to 10k by end of work day. Arms and legs are pretty ripped, smaller than id like but pretty muscular.

Belly belly belly always been my problem. Shaped like a fucking potato. Had to stop glp1s for a month due to medical shit and just started back up on the 11th.

Sounds like you're eating at maintenance right now, even with the snacks. So not a bad thing.

I really recommend tracking everything, old saying "if we can measure it, we can improve it". Get a food scale of Amazon and it sucks when you first start doing it. The good thing is most of us are creatures of habit and we tend to eat the same dozen things, most of the time. Samsung health has a built in food tracking feature, and you can custom save each meal for later use.I would guess Apple does too. If not, tons of apps are out there.

Do this for the next week and dont change anything. This will give us a solid baseline number. Once we have that we can start making some small changes. After the initial week I would reduce my avg daily caloric intake by just 100 calories. You can do this by shear will, but that sucks, or up the tirz a little. Im not familiar with cagri, but a lot of people like it too. From there if you start losing after pulling 100 calories a day out and you're happy with the rate, good to go. If not, pull another 100 out a day for the next week. Rinse and repeat until you're loosing at a solid, comfortable rate. The small changes make it easier to adjust for me.

Keep in mind as we get lighter our base metabolic rate naturally decreases.

The next thing is making time to lift weights. I have fallen in love with lifting again. Its something that was a huge part of my life in my teens and 20's.

The best part is, once you shift from cutting and have some more muscle you can eat more, by this point food shifts from being a pleasure thing to a fuel thing, still enjoyable but a different mindset. This happens for me, I guess everyone is different, so your milage may vary.

You've made a ton of progress so far, dont forget that. Could you imagine putting the weight you lost in a backpack and wearing it all day. It would be exhausting.

Keep up the hard work!

 

[FRMN01]

Thats what my current roll is. I am maintaining for the last month and a half 214 to 219 but kind of stalled. 215 and change today, but a month and a half ago I was 213.

Somehow, after a month off the glp1s I've managed to hold my weight down but now 3 shots in still hungry unfortunately. Time to make a move.

Want to reach Onederland at the least and 190 at the most to see how I feel there.

My current dosing is the title. Do I titrate up on the tirz or reta? Add cagri? Not really sure where to go for some reason i have 15 in my head as the limit but I know its not.

I can even reconstitute tirz at 30mg/ml and we decided we can do that with reta as well, right? Increase concentration to make the shooting amounts smaller.

So bummed to be building a tolerance but I need to keep bumping up if I need to so close to goal. Advice welcomed.

I know my avenues to stroll down to fix this just need help to choose the best one.

Cagri got things moving for me. I'm on 6.5 mg Tirz + 0.8mg cagri on Monday and 6.5 reta + 0.8mg cagri on Friday. Also added Semax for energy when needed, usually every other day + 2-3 drops of Lugol iodine every other day. I was very slow responder, but last month lost 5lb. So something is working.

 

[Gr33dyOctopus]

Sounds like you're eating at maintenance right now, even with the snacks. So not a bad thing.

I really recommend tracking everything, old saying "if we can measure it, we can improve it". Get a food scale of Amazon and it sucks when you first start doing it. The good thing is most of us are creatures of habit and we tend to eat the same dozen things, most of the time. Samsung health has a built in food tracking feature, and you can custom save each meal for later use.I would guess Apple does too. If not, tons of apps are out there.

Do this for the next week and dont change anything. This will give us a solid baseline number. Once we have that we can start making some small changes. After the initial week I would reduce my avg daily caloric intake by just 100 calories. You can do this by shear will, but that sucks, or up the tirz a little. Im not familiar with cagri, but a lot of people like it too. From there if you start losing after pulling 100 calories a day out and you're happy with the rate, good to go. If not, pull another 100 out a day for the next week. Rinse and repeat until you're loosing at a solid, comfortable rate. The small changes make it easier to adjust for me.

Keep in mind as we get lighter our base metabolic rate naturally decreases.

The next thing is making time to lift weights. I have fallen in love with lifting again. Its something that was a huge part of my life in my teens and 20's.

The best part is, once you shift from cutting and have some more muscle you can eat more, by this point food shifts from being a pleasure thing to a fuel thing, still enjoyable but a different mindset. This happens for me, I guess everyone is different, so your milage may vary.

You've made a ton of progress so far, dont forget that. Could you imagine putting the weight you lost in a backpack and wearing it all day. It would be exhausting.

Keep up the hard work!

Thank you buddy!
Thats a lot to unpack, hope you used a keyboard and not a phone to type all that!
I do have an amazon scale, lol thats sitting in its box since I ordered if feom amazon. Honestly its the snacks during the daytime, I know whats holding me at maintenance. And I have a paid for food tracking app too, "loseit" bought a year 10 months ago and haven't used that either 😂 you are right i should track that, especially the bad shit I've been eating that have stopped the weight loss.

Im gonna go ahead and up the tirz, track the calories, and see where that goes. All good advice my friend.

I also love lifting weights and do lift weights 5 days a week. Don't even have a choice, leading senior fitness classes was wild when I was 330 pounds, and even more wild now because I enjoy it so much more.

Ty again!

🤗🤗🤗🤩

 

[Gr33dyOctopus]

Cagri got things moving for me. I'm on 6.5 mg Tirz + 0.8mg cagri on Monday and 6.5 reta + 0.8mg cagri on Friday. Also added Semax for energy when needed, usually every other day + 2-3 drops of Lugol iodine every other day. I was very slow responder, but last month lost 5lb. So something is working.

How was your energy? Does it make you sleepy?!

 

[Gr33dyOctopus]

Buddy... You gotta count the calories. It's not optional. You got the easy weight off, now you have to lock in.

Congratulations on the loss!

And as far as stacking is concerned, I gotta say go up on the reta until you get sides or you find the dose to be effective

Thank you sir, ur absolutely right. Already lost the easy weight lol

 

[Gr33dyOctopus]

I really hope this is not an example of the rat study where they stopped and started semaglutide and those rats put on weight in between and progressively ended up losing less weight each time they went back on the GLP drug. It does sound like the same dose is being less effective at appetite suppression than it was before stopping it for a month.

I did think of a possible cause, Assuming you restarted at the same or similar dose rather than at a lower dose and built up, you will have much lower blood levels than steady state ( about half ) as it will take 4 weeks on that dose to get back to steady state levels. This could easily be enough to explain what you are experiencing and in theory the problem should sort itself out by the 4th dose/week. But you could put your doses into glp plotter and see when you get to consistent blood levels. If you only restarted on the 11th, this does make sense as a cause.

It makes total sense, and I've absolutely considered it, jist literally terrified that those rat studies and human trials where the pause creates a need for more to get back to where i was. Pin again tomorrow, going to up the tirz to 8, which is the most I've ever done in a single shot, and hope.for the best, potentially upping the reta 3 or 4 days later depending on how I feel on monday

 

[FRMN01]

How was your energy? Does it make you sleepy?!

Yes, it did make me sleepy in the beginning, for about a week or so. good thing I had Semax handy, 0.5mg EOD.

 

[endlrls]

Fair enough. Im not counting calories, but i am digging into snacks at work now such as chips and mini candy bars. I wasnt doing that for about 9 months. Now I am, plus I've added some Costco trail mix bags to the mix.

Previously I was fasting 16 hours and eating in an 8 hour window and the weight came off regularly.

At home still mainly eating grilled meats and veggies but dreaming of pizza and sub sanddwiches.

Work is busy, I lead 1 to 2 exercise groups with weights bands and balls across a couple of buildings. And get in 6k steps or more by noon each day, usually end with 8 to 10k by end of work day. Arms and legs are pretty ripped, smaller than id like but pretty muscular.

Belly belly belly always been my problem. Shaped like a fucking potato. Had to stop glp1s for a month due to medical shit and just started back up on the 11th.

I call it the "Cat Flap" for the belly... Same here.. Body looks "decent" but that cat flap just hangs on for dear life!!...

 

[endlrls]

Sounds like you're eating at maintenance right now, even with the snacks. So not a bad thing.

I really recommend tracking everything, old saying "if we can measure it, we can improve it". Get a food scale of Amazon and it sucks when you first start doing it. The good thing is most of us are creatures of habit and we tend to eat the same dozen things, most of the time. Samsung health has a built in food tracking feature, and you can custom save each meal for later use.I would guess Apple does too. If not, tons of apps are out there.

Do this for the next week and dont change anything. This will give us a solid baseline number. Once we have that we can start making some small changes. After the initial week I would reduce my avg daily caloric intake by just 100 calories. You can do this by shear will, but that sucks, or up the tirz a little. Im not familiar with cagri, but a lot of people like it too. From there if you start losing after pulling 100 calories a day out and you're happy with the rate, good to go. If not, pull another 100 out a day for the next week. Rinse and repeat until you're loosing at a solid, comfortable rate. The small changes make it easier to adjust for me.

Keep in mind as we get lighter our base metabolic rate naturally decreases.

The next thing is making time to lift weights. I have fallen in love with lifting again. Its something that was a huge part of my life in my teens and 20's.

The best part is, once you shift from cutting and have some more muscle you can eat more, by this point food shifts from being a pleasure thing to a fuel thing, still enjoyable but a different mindset. This happens for me, I guess everyone is different, so your milage may vary.

You've made a ton of progress so far, dont forget that. Could you imagine putting the weight you lost in a backpack and wearing it all day. It would be exhausting.

Keep up the hard work!

A Food Scale and MyFitnessPal can be daunting at first, but man... it opens your eyes up to food... and just how like a "little Piece" of cake or something is like 42,000 calories! lol

 

[MikeyMike]

Fair enough. Im not counting calories, but i am digging into snacks at work now such as chips and mini candy bars. I wasnt doing that for about 9 months. Now I am, plus I've added some Costco trail mix bags to the mix.

Previously I was fasting 16 hours and eating in an 8 hour window and the weight came off regularly.

At home still mainly eating grilled meats and veggies but dreaming of pizza and sub sanddwiches.

Work is busy, I lead 1 to 2 exercise groups with weights bands and balls across a couple of buildings. And get in 6k steps or more by noon each day, usually end with 8 to 10k by end of work day. Arms and legs are pretty ripped, smaller than id like but pretty muscular.

Belly belly belly always been my problem. Shaped like a fucking potato. Had to stop glp1s for a month due to medical shit and just started back up on the 11th.

I would say cut the snacks at work at least in half and skip the trail mix. Trail mix is very calorie dense and easy to over consume. Bring fruit to the office to keep the candy at bay. That is one thing I found about GLPs is it is still too easy to over consume candy and chips. So best to reduce or eliminate them altogether. Calorie dense foods are the enemy!

How's your body composition? Do you check with an InBody or similar scale? I have been at a stall for about 3 months now, only dropping like 2 lbs (cw 190, gw 180). However have noticed putting on 6 pounds of muscle, while dropping 11 pounds of fat. Yes, I know that still leaves about 3 pounds unaccounted for, likely water retention from HGH. So I am perfectly fine with this progress, as I am finally getting rid of my gut, been way too long for me.

Have you had your hormones checked? Optimizing hormones can be a game changer for body recomp and getting the belly to go away.

 

[Spork]

Those Costco trail mix snack size bags are the devil! lol

I mean look, most of that is healthy and you're getting proteins from the nuts but let's face it, it's the m&m's in there that make it what it is!

How many calories in a package again?

 

[reta-stacker]

Jeez, you're leading an active life, getting in lots of steps, lifting weights, leading exercise classes, pinning a couple of glps regularly but still in a stall. Life's unfair! Your confession on how snacks and trail mix have slipped back into your life seems like the most likely culprit, but others before me have pointed that out. Measuring calories and monitoring food intake would be helpful since you can set more empirically measurable and modest goals. Time to take that smart scale outta the box and fire up the app. Meanwhile, be proud of what you've already accomplished.

 

[endlrls]

Those Costco trail mix snack size bags are the devil! lol

I mean look, most of that is healthy and you're getting proteins from the nuts but let's face it, it's the m&m's in there that make it what it is!

How many calories in a package again?

Literally "cAnDy In A bAg..."

 

[Gr33dyOctopus]

Those Costco trail mix snack size bags are the devil! lol

I mean look, most of that is healthy and you're getting proteins from the nuts but let's face it, it's the m&m's in there that make it what it is!

How many calories in a package again?

So many 😂😂💩

 

[Gr33dyOctopus]

Jeez, you're leading an active life, getting in lots of steps, lifting weights, leading exercise classes, pinning a couple of glps regularly but still in a stall. Life's unfair! Your confession on how snacks and trail mix have slipped back into your life seems like the most likely culprit, but others before me have pointed that out. Measuring calories and monitoring food intake would be helpful since you can set more empirically measurable and modest goals. Time to take that smart scale outta the box and fire up the app. Meanwhile, be proud of what you've already accomplished.

Thank you very much.. yea its the chips and candy bars and trail mix. We have a giant bingo cabinet stocked by independent residents and it is PACKED with yummy stuff like fig newton's, Costco chip assortment, mini candy bar and chocolates, circus animal.cookies, vanilla wafers. You name it, its bad for you and delicious its in there. And my desk is about ten feet away its criminal 😭.

For so many months I was able to ignore it but like a hot and crazy ex gf it keeps itself in my peripheral vision these days.

And yes, im extremely lucky to get the exercise i get, and not only that but choose what exercise we do and how many reps. Oh and 15 to 30 minutes pf stretches each day too. And paid a decent wage for it. Could have my assistants lead the classes, i used to, but took ALL the different exercise classes over except dance 🕺 😅😂🤣

 

[TacoLifter420]

Thank you buddy!
Thats a lot to unpack, hope you used a keyboard and not a phone to type all that!
I do have an amazon scale, lol thats sitting in its box since I ordered if feom amazon. Honestly its the snacks during the daytime, I know whats holding me at maintenance. And I have a paid for food tracking app too, "loseit" bought a year 10 months ago and haven't used that either 😂 you are right i should track that, especially the bad shit I've been eating that have stopped the weight loss.

Im gonna go ahead and up the tirz, track the calories, and see where that goes. All good advice my friend.

I also love lifting weights and do lift weights 5 days a week. Don't even have a choice, leading senior fitness classes was wild when I was 330 pounds, and even more wild now because I enjoy it so much more.

Ty again!

🤗🤗🤗🤩

I guess im must be a bit of a masochist, typed all that on my phone. Or I was feeling Friday's leg day and did want to get up from the couch ; ).

 

[reta-stacker]

OMG, stop! You're making me hungry!! That really is an unfair challenge to have all that bad food so close to where you work!

 

[Skidude]

Thats what my current roll is. I am maintaining for the last month and a half 214 to 219 but kind of stalled. 215 and change today, but a month and a half ago I was 213.

Somehow, after a month off the glp1s I've managed to hold my weight down but now 3 shots in still hungry unfortunately. Time to make a move.

Want to reach Onederland at the least and 190 at the most to see how I feel there.

My current dosing is the title. Do I titrate up on the tirz or reta? Add cagri? Not really sure where to go for some reason i have 15 in my head as the limit but I know its not.

I can even reconstitute tirz at 30mg/ml and we decided we can do that with reta as well, right? Increase concentration to make the shooting amounts smaller.

So bummed to be building a tolerance but I need to keep bumping up if I need to so close to goal. Advice welcomed.

I know my avenues to stroll down to fix this just need help to choose the best one.

I am not an expert, Doc or Nutritionist..
But having seen your posts lately I can toss out an opinion.

You spent several weeks cold turkey and gained weight prior to medical needs
The medical issue is wanting to heal your body and craving more food
Your levels were decreased and have not had time to bounce back
What you feed your Biome it craves VIDEO HERE and its been feasting...

If you want to increase you can but it might fix itself as the levels go back up and the snacks slow down.

Good luck!

 

[Beardboost]

I have run both Triz and Reta now for 14 weeks, 58 pounds lost, 5/5mg each taken every 6 days, 2 days in-between Reta and Triz

 

[Gr33dyOctopus]

I am not an expert, Doc or Nutritionist..
But having seen your posts lately I can toss out an opinion.

You spent several weeks cold turkey and gained weight prior to medical needs
The medical issue is wanting to heal your body and craving more food
Your levels were decreased and have not had time to bounce back
What you feed your Biome it craves VIDEO HERE and its been feasting...

If you want to increase you can but it might fix itself as the levels go back up and the snacks slow down.

Good luck!

Thank you!! I believe you are 100 percent correct! Maybe you should be a dr. or nutritionist lol!!! I increased this morning by 1 mg on tirz for a total of 8mg per week, will either keep reta at 7 or drop it slightly later in the week. Good looking out!

 

[woundcarping]

...will either keep reta at 7 or drop it slightly later in the week...

Why would you change two variables in opposite directions? That seems counterproductive unless you're running into sides.