Which drug has the best side effect profile?

[tcpnomad]

What is your sense of the side effect profile for all the different drugs on the market these days?

Semaglutide, Tirzepatide, Retatrutide, Eloralintide, Cagrilintide (and other more exotic ones).

What is your thought process in deciding between all of these? Side effects vs efficacy?

 

[Aladran]

I think you don’t really know until you try them. Nausea is a side effect of all of them, but I’ve read anecdotal reports that some will be nauseous on sema but not on tirz and vice versa

 

[bada bing]

If you want best chance of manageable sides, then your dosing ramp up is at least as important as the compound. If I was choosing a best bet for effectiveness verses sides, I'd try Tirzepatide first. But that's only a bet, not a certainty for any one individual.

Some of the subscription based compounding outlets have pretty conservative standard protocols for getting people onto Tirzepatide: Start at 1mg/week for first two weeks then make a decision to go to 2mg if well tolerated. Evaluate for increases every 4 weeks afterwards. Patience has the best chance of avoiding unpleasant sides.

You're going to feel a little different at an effective dose of any of the GLPs. It's not ever going to be just transparent weight loss.

That's not a recommendation, just an observation.

 

[Sasquatch]

Yes, if you're looking for nausea there's a better chance with Sema.
Reta could raise your heart rate.
There's a thousand ways to get hurt or die. Let's be careful out there.

 

[Flash-BCR]

I think you don’t really know until you try them. Nausea is a side effect of all of them, but I’ve read anecdotal reports that some will be nauseous on sema but not on tirz and vice versa

I have all the ones OP listed except Elora...To date, I am only doing Tirz because so far, it works just fine. Its also the one I put up 8-10years +/- worth...I've got a fair amount of Reta including a couple of R10 kits to try out smaller doses to start...and then a couple kits each of sema and cagril in case I ever want to try appetite killers...The tirz works, I am betting the reta split dose with tirz is a smart bet when I get to that point...and the cagril and maybe the sema will be nice add ons...but like you said, you won't know until you try them... 👍

 

[lessthanhalf]

I do not think there is any doubt that tirzepatide has the lowest overall rate of side effects, followed by reta then semaglutide, assuming titrating to maximum doses.
Cagri has high rates of side effects, elora is a bit odd in that low doses seem to have quite low rates of side effects but higher doses sound a lot more problematic.
It also depends a bit on how much weight needs to be lost, as low dose reta at 1-4mg has pretty good weight loss at low side effect rates, as does low dose cagri at 1-3mg. It might be that a lower dose of reta could end up more tolerable than a higher equivalent weight loss dose of tirz?