Orforglipron: The next big thing?

[Calm Logic]

I would caution anyone researching orfor to keep and eye on your liver function studies especially if taking anything that is broken down by liver metabolism: statins, antidepressants , some cardiac medications, seizure meds, pain meds and many more. Oh, if you drink alcohol be very careful.

Most all prescription drugs have some sort of delivery system. Throwing some raw powder in a capsule and calling it a pill is like comparing a a pair of roller skates to a Mercedes sedan. They move you down the road but I would rather be in the Mercedes. It’s a lot safer! A lot of medications are very caustic to the distal esophagus especially if you have reflux. A proper designed pill or tablet will get it into the small intestine before being dissolved. These are just things to think about. No telling what Uther, SSa, peptide sciences and the likes are selling. I would love for someone to show a picture of the ORFOR pill that they are taking. I would bet money that it is a capsule. Maybe that is not an issue? We just don’t know yet so caution is advised.

I do agree about the liver testing, even if using orfo from Big Pharma. There were some people with elevated ALTs in the studies, but it was usually transient and similar to the placebo group. The cost for a CMP with ALT and AST is just a few dollars anyway with my Fitomics subscription.

The Chinese have been selling grey capsules and tablets for many years, so I'm not too worried. Loading up on glutathione or oral NAC, including beforehand, may help mitigate some drug-induced liver injury, though obviously only so much compared to stopping the offending medication.

Some who already bought grey orfo mostly want it for occasional rather than daily use, like day 5 and 6 of a tirz week. But I do appreciate the word of warning, especially for daily use.

 

[Jellybelly54]

Yes, glutathione and NAC are great. You can also get labs done through a website called Walkinlab.com

https://walkinlab.zinrelo.com/ref/ERI4LI4X

They are a Labcorp affiliate . Basically pay for labs you want and go to a LabCorp and get your blood drawn. Get results in a few days. The above link will get you 20% off

 

[Calm Logic]

Yes, glutathione and NAC are great. You can also get labs done through a website called Walkinlab.com

https://walkinlab.zinrelo.com/ref/ERI4LI4X

They are a Labcorp affiliate . Basically pay for labs you want and go to a LabCorp and get your blood drawn. Get results in a few days. The above link will get you 20% off

Still costly compared to some other sites, compared here:

Blood Test Order Sites Pricing - Snapshot (Updated 2025OCT06)

docs.google.com

Rythm VS Quest blood tests

I was curious how legit Rythm Health blood tests were so I decided to try them side by side with my annual physical and blood test. Rythm seemed too good to be true with the tiny vial you fill then send in and it hit like 30 biomarkers for $100 after shipping. But I figured it was worth a shot...

glp1forum.com

 

[Jellybelly54]

Still costly compared to some other sites, compared here:

Blood Test Order Sites Pricing - Snapshot (Updated 2025OCT06)

docs.google.com

Rythm VS Quest blood tests

I was curious how legit Rythm Health blood tests were so I decided to try them side by side with my annual physical and blood test. Rythm seemed too good to be true with the tiny vial you fill then send in and it hit like 30 biomarkers for $100 after shipping. But I figured it was worth a shot...

glp1forum.com

Thats great info. Thanks!