Thank you, @geoguy78. I’ll definitely do that research. I’m actually on my third day of tesofensine, 250 mcg capsules from Kimera. First day took less than that by emptying just a bit into an empty capsule. Felt really great, really clean. Yesterday and today have taken just the one 250 mcg dose. Doing well, no problems. Still, I’ve read about the very long half-life and the insomnia issues people have had when it builds up and want to avoid that, so thinking I’ll skip taking any on the two weekend days. Definitely need to learn more about orforglipron, but your reply is helpful and I appreciate it. If I do try it, I’ll post back to this thread on how it affects me, and how they both work together. So far on the Teso, I do notice some hunger suppression though not super major. Read that keeps building, too.