The urge to stock up peps in the freezer is coming back

lessthanhalf said:
I guess that at some point in the not too distant future China will crack down on it internally. Won't happen for a few years, but once they have several home grown peptides on the market locally, I imagine these new potentially highly profitable companies will not be happy with the competition that did not have to pay for the research. And I would guess that China will want to market them worldwide, especially to the less rich countries. The possible amounts of money involved are insane, maybe even a trillion dollars, even if they end up selling them for a quarter or a tenth the price of current glp's. Probably not for 3 to 5 years is my guess, but it makes stockpiling hard to work out, probably need 8 to ten years worth to be safeish, until there is a lot of competition and generics. There are about 200 obesity related medications currently in drug development, so there will be better and cheaper ones eventually.
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This is the one that worries me. However if things it rough generic sema is real close and will probably be a very easy option to cross borders if it gets really bad. I still keep wanting to add. I'm fighting myself between more reta or Tirz.
 
Nmcoyote1 said:
I was looking at drug trials/ whats coming in the next few years and so far nothing really interesting besides Reta and Bimagrumab. Bimagrumab is a human antibody that is being trailed with Tirz. Making it unlikely to be available grey. But anything could happen as Reta as been available to us for almost a year already. Anything else does not look as good but could help some of us. As Sema worked wonders for me without the bad side effects others mention.
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The one I'm really looking forward to is eloralintide to stack with reta for maintenance. Potentially the ultimate appetite suppression and weight loss combo. I'm doing tirz/reta in lower doses for maintenance now, but I would like to experiment with eloralintide.

The other one I'm looking forward to is orforglipron for the wife. She won't do shots and doesn't have a lot to lose. It would be perfect for her.
 
BH_LOVER said:
I would have far more in my freezer if my 60 year old brain really wanted to figure out crypto.
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I'm 56 and spent an hour+ lastnight trying to figure out how to use crypto 😭. Then I looked at an old spreadsheet and realized I still have 4+ years of Sema, and a year + each of Tirz and Reta at maximum doses. So maybe I need to slow down 🐢
 
m100568 said:
The one I'm really looking forward to is eloralintide to stack with reta for maintenance. Potentially the ultimate appetite suppression and weight loss combo. I'm doing tirz/reta in lower doses for maintenance now, but I would like to experiment with eloralintide.

The other one I'm looking forward to is orforglipron for the wife. She won't do shots and doesn't have a lot to lose. It would be perfect for her.
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I wonder how long before it will be available?( eloralintide)
 
Habibibi said:
People really should stop stockpiling, prices are falling all the time.

I just made a buy for 400$ worth of product this week
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I was looking thru my spreadsheet of what I bought last year and prices for weight loss peptides are currently about half what I paid before June 2025. But it did make me feel secure knowing I had a multiyear supply of something that changed my life for the better.
 
Peotidethrowaway said:
Yeah I have so much Reta that I bought at 1.50 or so a mg I’d really rather not have spent that money
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I looked at my spreadsheet last night and realized I paid between $1 and $2 for Reta that is now $0.46 a mg from a trusted source. My last peptide buy for 500mg Reta was $1mg in June 2025. At that point I mostly started ignoring places like this because of my urge to stockpile.
 
Nmcoyote1 said:
I'm 56 and spent an hour+ lastnight trying to figure out how to use crypto 😭. Then I looked at an old spreadsheet and realized I still have 4+ years of Sema, and a year + each of Tirz and Reta at maximum doses. So maybe I need to slow down 🐢
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Well there ya go!
 
Interesting. I have a year supply. I guess I figure much better peptides are coming, and the ones we're currently using will seem like dinosaurs and outdated in a couple years. There are already many new drugs coming down the pipe that are better.
 
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I think that the big companies are not looking for better as much as a different niche to occupy. Someone who has a billion dollars to spend on development is keeping a sharp eye to market share. So these old drugs will still work, and new drugs will not tend to directly obsolete anything unless we get a new breakthrough class of drugs altogether. And people will still stack trying to find a mix that hits their needs.
 
That is a hard calculation to work out , if I wait and stock up later, it will be cheaper, going on trends over the past year or so, but if I wait too long to stock up they might suddenly not be available. The idea of that happening genuinely gives me anxiety. The last time I worked it out it would cost about $900 usd for 2000mg tiz and 600mg reta which would be about 3 extra years as I am taking both. Given a cardiovascular risk of about 25-30% ( death, heart attack, stroke) over the next 10 years, even if I stay normal weight (without statins etc and about half that with treatment), and a lot worse at 145 kilos, and the fact that there is no way I could afford retail prices, it is probably reasonably cheap life insurance.
 
If it’s likely a lifetime need, inventory management and access will be an ongoing thing.

Freezer life is finite relative to the ~40 years I have left. Taking 30 year old stash from the “good old days” seems unlikely.

I’m on the fence about maintaining a prescription for regulatory changes/opportunities moving forward. I’m ~4-6 months away from not being eligible to start a Tirz prescription under current guidelines and maybe 9-12 months from target weight.

When I am stable at maintenance weight, I plan to titrate down to a minimum effective dose for that goal to reduce my consumption and amount I’ll need to source over that time.

I plan for access to a variety of glp in case needs, tolerance, or availability change. While X may be preferred, in a pinch, y or z may be a preferable alternative.

A reasonable part of inventory management should also be first in, first out, to preserve inventory age. Tracking batches, coa, dates, and usage seems reasonable to me. Spoilage is a thing, be it from age or accelerated by condition.

A lessor concern, but still worth consideration if the paraphernalia required to administer. Syringes are easier to store longer, BAC water probably won’t last as long in storage.

I could figure out paying for a lifetime supply now, but spoilage and developments (regulatory, pricing, efficacy developments, etc) make that foolish it seems.

So, having a few years of a few options is my landing point for now. If/when I get to target weight and get stable on peptide and dosage, it probably makes sense not to keep as much in alternative options on hand. If I live another 40 years, no point in leaving a century of max dose peptides behind.


My general theory is to have enough supply on hand to bridge a change of intermediate length. ~3 years of max dose of the main varieties seems like a suitably robust model for myself at this point.
 
woundcarping said:
If it’s likely a lifetime need, inventory management and access will be an ongoing thing.

Freezer life is finite relative to the ~40 years I have left. Taking 30 year old stash from the “good old days” seems unlikely.

I’m on the fence about maintaining a prescription for regulatory changes/opportunities moving forward. I’m ~4-6 months away from not being eligible to start a Tirz prescription under current guidelines and maybe 9-12 months from target weight.

When I am stable at maintenance weight, I plan to titrate down to a minimum effective dose for that goal to reduce my consumption and amount I’ll need to source over that time.

I plan for access to a variety of glp in case needs, tolerance, or availability change. While X may be preferred, in a pinch, y or z may be a preferable alternative.

A reasonable part of inventory management should also be first in, first out, to preserve inventory age. Tracking batches, coa, dates, and usage seems reasonable to me. Spoilage is a thing, be it from age or accelerated by condition.

A lessor concern, but still worth consideration if the paraphernalia required to administer. Syringes are easier to store longer, BAC water probably won’t last as long in storage.

I could figure out paying for a lifetime supply now, but spoilage and developments (regulatory, pricing, efficacy developments, etc) make that foolish it seems.

So, having a few years of a few options is my landing point for now. If/when I get to target weight and get stable on peptide and dosage, it probably makes sense not to keep as much in alternative options on hand. If I live another 40 years, no point in leaving a century of max dose peptides behind.


My general theory is to have enough supply on hand to bridge a change of intermediate length. ~3 years of max dose of the main varieties seems like a suitably robust model for myself at this point.
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I’m not confident where civilization is heading and having this level of modern medicine requires quite a high level of cooperative and altruistic behavior. I think that gradually accumulating a lifetime of meds over the next 1-2 years is reasonable, and if something politcally untoward happens, can top up at a slightly higher rate.

I hope to keep dementia at bay long enough to use up my stash, but if not, faster checkout is preferred so keeping blood sugar, lipids, blood pressure, good immunity and all that under control becomes moot… so y’all can come to my estate sale and you know what to look for. Peppys taught us to label and keep good records. And lyophilized molecules can be extremely stable under many circumstances. It goes along with the 3 months of staple food supply the FDA is recommending we keep on hand, as guaranteed supply might be a problem in acute or chronic emergency situations . Peppers and preppers, what a timeline.
 
That's kinda where I'm landing, too. My pep of choice is tirz as it's just humming along doing what it needs to for me: I get hungry but don't need to immediately eat, and the food noise is a distant memory. All good and I'm sure I'll use it as my maintenance pep. As such, I now have ~5 years in the fridge assuming max dose of 15mg (but I've been on 12-13mg for the last 4 months).

That said, I've ordered reta (which I'm starting to dose to see if it can short term move the needle to goal weight, so I can then just take the tirz) and am this morning snooping around survo and cagri, debating if I should grab a kit of those to see what they do. And if I do like them, storing up a few more kits.

I agree, having options in our stash moving forward is probably a good idea as things are indeed getting even weirder in the world, and although the channels to the China market should remain open, I'm just worried specifically being in the US that border access even for purchases from overseas could get trickier. I'm not a prepper, but I'm a planner - so I feel better knowing I've got that 5 years of tirz. Better drugs might come out, but access and cost are unknown (the nature of "the future") and as these aren't breaking the bank for me, I don't feel like it would be money terribly wasted if I'm proven wrong and we get a lot of options for cheap in the next few years.
 
Labcat said:
I’m not confident where civilization is heading and having this level of modern medicine requires quite a high level of cooperative and altruistic behavior. I think that gradually accumulating a lifetime of meds over the next 1-2 years is reasonable, and if something politcally untoward happens, can top up at a slightly higher rate.

I hope to keep dementia at bay long enough to use up my stash, but if not, faster checkout is preferred so keeping blood sugar, lipids, blood pressure, good immunity and all that under control becomes moot… so y’all can come to my estate sale and you know what to look for. Peppys taught us to label and keep good records. And lyophilized molecules can be extremely stable under many circumstances. It goes along with the 3 months of staple food supply the FDA is recommending we keep on hand, as guaranteed supply might be a problem in acute or chronic emergency situations . Peppers and preppers, what a timeline.
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OMG, we posted almost the exact same response at the same time. SAME girl, SAME.
 
ThatNextGril said:
OMG, we posted almost the exact same response at the same time. SAME girl, SAME.
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🩷. Planning is definitely needed nowadays. Some areas with recent floods and fires are still not livable and that stuff ain’t slowing down. I agree that figuring out what works better as our health status moves is part of our job no one else will do for us, so we’ll have better and hopefully “easier” paths and backup paths which are suboptimal and more work. No one here is a stranger to that, anyway. We’re already dealing with the obstacles bigpharma and insurance are putting up.
 
Labcat said:
I’m not confident where civilization is heading and having this level of modern medicine requires quite a high level of cooperative and altruistic behavior. I think that gradually accumulating a lifetime of meds over the next 1-2 years is reasonable, and if something politcally untoward happens, can top up at a slightly higher rate.

I hope to keep dementia at bay long enough to use up my stash, but if not, faster checkout is preferred so keeping blood sugar, lipids, blood pressure, good immunity and all that under control becomes moot… so y’all can come to my estate sale and you know what to look for. Peppys taught us to label and keep good records. And lyophilized molecules can be extremely stable under many circumstances. It goes along with the 3 months of staple food supply the FDA is recommending we keep on hand, as guaranteed supply might be a problem in acute or chronic emergency situations . Peppers and preppers, what a timeline.
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Do you expect lyophilized GLP/GIP/Glucagone/Amylin peptides to remain stable and suitable viable for decades? Under what conditions? I haven't seen reliable data to support that idea, anecdotally here I've seen people say Jano said he tested decade old garage freezer Tirz and it was largely unchanged.

12mg Reta/week, 50 years, $.48/mg= $15k
15mg Tirz/week, 50 years, $.30/mg= $11.7k
2.4mg Sema/week, 50 years, $.47/mg= $2.9k
4.5mg Cagri/week, 50 years, $1.34/mg= $15.7k


Those figure "max" doses but not wastage, slippage, etc. Buying in bulk should negotiate a lower price, which should give a margin in the dollar amount to account for the wastage.



Fun facts, 15mg/Tirz a week for 50 years is 39gr. For just the peptide, 50 years would fit inside a ping pong ball with a little room (~10%) to spare. 50 years of Sema would fit in a teaspoon with ~10% room to spare.
 
woundcarping said:
Do you expect lyophilized GLP/GIP/Glucagone/Amylin peptides to remain stable and suitable viable for decades? Under what conditions? I haven't seen reliable data to support that idea, anecdotally here I've seen people say Jano said he tested decade old garage freezer Tirz and it was largely unchanged.

12mg Reta/week, 50 years, $.48/mg= $15k
15mg Tirz/week, 50 years, $.30/mg= $11.7k
2.4mg Sema/week, 50 years, $.47/mg= $2.9k
4.5mg Cagri/week, 50 years, $1.34/mg= $15.7k


Those figure "max" doses but not wastage, slippage, etc. Buying in bulk should negotiate a lower price, which should give a margin in the dollar amount to account for the wastage.



Fun facts, 15mg/Tirz a week for 50 years is 39gr. For just the peptide, 50 years would fit inside a ping pong ball with a little room (~10%) to spare. 50 years of Sema would fit in a teaspoon with ~10% room to spare.
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Frozen, vacuum sealed, well lyophilized. We keep complex living cells for decades at -80C, a simple rugged molecule like tirz might do very well even at home. Within the community, we do have some degradation tests for short term and undoubtedly more altruistic people will be curious as time passes; in a couple years, I’d sacrifice a few vials if I could afford the testing. Or maybe a lab might be more community minded and step up to clear up some basic questions.
 
When I look at my stash of peps, I think of the 15,000 syringes, alcohol pads and gallons of BAC I'm going to have to buy to get through it all. If they weren't commodity items, I'd invest in MHC Medical Products, McKesson and Pfizer just for that.
 
Chili777 said:
When I look at my stash of peps, I think of the 15,000 syringes, BAC and alcohol pads I'm going to have to buy to get through it all. If they weren't commodity items, I'd invest in MHC Medical Products, McKesson and Pfizer just for that.
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It’s like meals though, just gotta take them a week at a time and definitely not think of them all together.
 
Nmcoyote1 said:
I did see someone here say they have a eight year supply at max dose. But at current dosage they have a 24 year supply.
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That was almost certainly me. 😀 I wound up maxing out my hoard impulse at 10 year max supply, which is 18 years current dose (I went up from my original dose.) That was the magic mark where I went "Ok, I can calm down." Then I almost immediately started building a reta supply cAuSe whAt if TIrz stOps w0rKing? But at the rate I'm acquiring (about a kit every 1.5 months), I can't do much damage to either my wallet or my space. Anything that hits my addiction center but does NOT threaten either or those, my body, my character, or my ability to function as an adult, I usually shrug and let it have its way and know I'll get bored eventually.
 
Nmcoyote1 said:
I really do not know. I saw a Youtube by a doctor claiming prednisone and GLP-1’s cancel each other out because they have opposite effects. I also spoke to a doctor that claimed the same thing that was in A Reta Trial. He said it was probably best to try and not gain weight. But that I should not focus on weigh loss until off them. But that's hard to do as I've been on pred for six months and probably will be for at least another six months as I taper.
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I don't totally agree with that Doctor's take. I take 20mg of Prednisone daily for PsA. And I do agree that it can hinder weight loss progress a bit. But I've still lost over 50 lbs on Tirz while taking the Prednisone.
I tried at one point to quit the prednisone, but my hands broke out with Psoriasis and joints started flaring. 20mg is half what I took before Tirz. So all in all, the anti-inflamitory properties of the Tirz has helped to curb the overall need for the Prednisone.
Also, due to my Tirz use, I no longer need take insulin. My A1c has gone from 12.4 to 6.
I asked Gemini to see what it said:

AI Overview

Prednisone and GLP-1 receptor agonists (like Ozempic, Wegovy, and Mounjaro)
do not completely "cancel" each other out in a pharmacological sense, but they have directly opposing effects on blood sugar and weight, which can make them less effective when taken together.
While they can be taken concurrently under medical supervision, prednisone often negates the metabolic benefits of GLP-1s by driving up blood glucose and increasing appetite.
Here is a breakdown of how these medications interact:

1. Opposing Effects on Blood Sugar
  • Prednisone: Increases blood sugar by promoting insulin resistance and inducing glucose production in the liver. It is well-known for causing hyperglycemia.
  • GLP-1s: Lower blood sugar by increasing insulin secretion and slowing gastric emptying.
  • The Interaction: Prednisone's hyperglycemic effects can counteract the blood sugar-lowering benefits of GLP-1s, leading to higher-than-usual glucose readings.

2. Opposing Effects on Weight
  • Prednisone: Frequently causes increased appetite, fluid retention, and weight gain.
  • GLP-1s: Promote weight loss by reducing appetite and increasing satiety.
  • The Interaction: Prednisone may cause weight stability or weight gain, which can undermine the weight-loss goals of a GLP-1 patient.

3. Key Considerations and Management
  • Not a "Cancel Out": The drugs are still in your system doing their jobs; they are just fighting against each other, with the steroid effect often being more powerful on acute blood sugar levels.
  • Temporary vs. Long-Term: A short "burst" of prednisone might cause temporary, manageable issues, while long-term use is more likely to completely offset the benefits of a GLP-1.
  • Monitoring is Essential: Individuals on this combination should monitor blood glucose closely and may need temporary adjustments to their diabetes medication dosages.
  • Do Not Stop Either Medication: You should not stop taking either medication without consulting your doctor, as abrupt cessation of prednisone can be dangerous.
Disclaimer: This information is for educational purposes only and does not constitute medical advice. Consult your healthcare provider for management of your specific medication regimen.
 
Nmcoyote1 said:
The one thing slowing me down is nobody seems to take easy payment solutions like Paypal anymore. Now it's all crypto. So now I have to learn how to use it
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I’m having the same issue lol. You can get crypto through PayPal but it doesn’t seem to work through PayPal so you have to do Coinbase or some other wallet
 
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