Therapeutic levels are commonly described at a steady state of 6-8mg/week dosing for ~4-5 weeks. It doesn't take a month to get a concentration level commiserate with the average exposure of 6-8mg/week dosing, which is 7.4mg-9.9mg. It can take time for the body to adjust to the signaling, even if the average exposure is reached more quickly through different dosing schedules.
The 4-5 weeks is because our current exposure is culmination of your current dose, plus the doses taken over the last ~24-30 days (Reta has a 6 day half life, 4-5 half lives until it's eliminated).
1mg is .5mg in 6 days.
.5mg is .25mg in 6 days
.25mg is .125mg in 6 days
.125mg is .0625 in 6 days
.0625mg is .03125mg in 6 days <<< eliminated
Simplified math explanation, assuming instant absorption and a 6 day dose schedule.
Day 0: 1mg
Day 6: .5mg (Day 0) + 1mg (Day 6)= 1.5mg cumulative.
Day 12: .13mg (Day 0) + .5 (Day 6) + 1mg= 1.63mg
Day 18: .06mg (0) + .25mg (6) + .5mg (12) +1mg= 1.81mg
Day 24: .03mg (0) + .13mg (6) + .25mg (12) + .5mg (18)+1mg= 1.91mg
Day 30: .0 (0) + .03mg (6) + .13mg (12) + .25mg (18) + .5mg (24) +1mg= 1.91mg <<<steady state peak
Sema and tirz's main strength being appetite suppression or control resulting in calorie reduction. Reta's unique strength is glucagon signaling, which increases base metabolic maybe around 10% while still offering appetite control resulting in less calorie input. That's presumptively why the GLP and GIP signaling is reduced per mg exposure compared to Sema or Tirz ( Reta has maybe 1/10th the GLP expression of Sema) so the dosage can be high enough to meaningfully utilize the glucagon signaling to have the metabolic rate bump without overdoing the GLP/GIP signaling.
The half lives are shown here by the long gradual tails after the peaks (doses). Their cumulative stacking affect is shown by the 5.7mg current level when my 9 shots have only been 1-2.5mg each.
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