Reta - No Effect

[Main75]

Maybe you won't respond until the higher doses 8-12 mg. Increase your dose, but not too fast.
It's not that uncommon to not respond to the lower doses. You are not at non-responder on the lower dose 4 mg.

Also consider if something else is going on, - did you have a full blood test panel before you started ? It's a good idea to have a baseline. If you have some metabolic issues, the drugs often need to be in higher doses to loose weight. You are only on 4 mg now. The medicine needs time to work.

And you don't say how much you need to loose, how high are you and what weight ?

At 310 lbs I started super low and slow at .5 mg for two weeks before moving up. Oct 4 310 lbs and december 17th 280lbs at 5 mg

Therapeutic levels are commonly described at a steady state of 6-8mg/week dosing for ~4-5 weeks. It doesn't take a month to get a concentration level commiserate with the average exposure of 6-8mg/week dosing, which is 7.4mg-9.9mg. It can take time for the body to adjust to the signaling, even if the average exposure is reached more quickly through different dosing schedules.

The 4-5 weeks is because our current exposure is culmination of your current dose, plus the doses taken over the last ~24-30 days (Reta has a 6 day half life, 4-5 half lives until it's eliminated).

1mg is .5mg in 6 days.
.5mg is .25mg in 6 days
.25mg is .125mg in 6 days
.125mg is .0625 in 6 days
.0625mg is .03125mg in 6 days <<< eliminated

Simplified math explanation, assuming instant absorption and a 6 day dose schedule.
Day 0: 1mg
Day 6: .5mg (Day 0) + 1mg (Day 6)= 1.5mg cumulative.
Day 12: .13mg (Day 0) + .5 (Day 6) + 1mg= 1.63mg
Day 18: .06mg (0) + .25mg (6) + .5mg (12) +1mg= 1.81mg
Day 24: .03mg (0) + .13mg (6) + .25mg (12) + .5mg (18)+1mg= 1.91mg
Day 30: .0 (0) + .03mg (6) + .13mg (12) + .25mg (18) + .5mg (24) +1mg= 1.91mg <<<steady state peak


Sema and tirz's main strength being appetite suppression or control resulting in calorie reduction. Reta's unique strength is glucagon signaling, which increases base metabolic maybe around 10% while still offering appetite control resulting in less calorie input. That's presumptively why the GLP and GIP signaling is reduced per mg exposure compared to Sema or Tirz ( Reta has maybe 1/10th the GLP expression of Sema) so the dosage can be high enough to meaningfully utilize the glucagon signaling to have the metabolic rate bump without overdoing the GLP/GIP signaling.


The half lives are shown here by the long gradual tails after the peaks (doses). Their cumulative stacking affect is shown by the 5.7mg current level when my 9 shots have only been 1-2.5mg each.
View attachment 14399

nice post …
Half life is important to understand and this shows it clearly.
I personally started at 308lbs and starting dose of .5mg. Clear results from the start.. December 17th 280lbs at 5mg.

Not perfect experience though…i popped 10 lbs over Christmas and flatlined loss for about a month.

Three things happened that I can point to.
-Christmas I cheated for a week (I assume that was the weight gain)
-ipamorelin started dec 23
-Reta supplier changed dec 23

Now Jan 23 sitting at 283 and at 8 mg for second week straight.

I get the weight gain but that resulting “stall” still has me a little puzzled


Thanks for your info

 

[woundcarping]

At 310 lbs I started super low and slow at .5 mg for two weeks before moving up. Oct 4 310 lbs and december 17th 280lbs at 5 mg

nice post …
Half life is important to understand and this shows it clearly.
I personally started at 308lbs and starting dose of .5mg. Clear results from the start.. December 17th 280lbs at 5mg.

Not perfect experience though…i popped 10 lbs over Christmas and flatlined loss for about a month.

Three things happened that I can point to.
-Christmas I cheated for a week (I assume that was the weight gain)
-ipamorelin started dec 23
-Reta supplier changed dec 23

Now Jan 23 sitting at 283 and at 8 mg for second week straight.

I get the weight gain but that resulting “stall” still has me a little puzzled


Thanks for your info

10lbs is only ~9 bottles of water.

To gain 10lbs of fat in a week you'd have to eat an extra 5000 calories a day... that seems unlikely. Ipamorelin can cause glycogen stores to increase (water weight), appetite increase, and lean mass increase. Enjoying the holidays plus less exercise plus a 'morelin could explain the weight stall without much effort.

Was it a stall, or getting back on track, adapting to ipamorelin, and getting the 10lb off more likely? Are you accurately tracking calories, macros, weight, medications, and exercise?


I started TRT this week which is expected to give me similar scale noise in the short term (water weight) before the longer term benefits present. I accounted for that in my trajectory plan and so far I'm 3-4lb lighter than when I started.

 

[Main75]

10lbs is only ~9 bottles of water.

To gain 10lbs of fat in a week you'd have to eat an extra 5000 calories a day... that seems unlikely. Ipamorelin can cause glycogen stores to increase (water weight), appetite increase, and lean mass increase. Enjoying the holidays plus less exercise plus a 'morelin could explain the weight stall without much effort.

Was it a stall, or getting back on track, adapting to ipamorelin, and getting the 10lb off more likely? Are you accurately tracking calories, macros, weight, medications, and exercise?


I started TRT this week which is expected to give me similar scale noise in the short term (water weight) before the longer term benefits present. I accounted for that in my trajectory plan and so far I'm 3-4lb lighter than when I started.

Good points ….thanks for the imput

 

[Main75]

At 310 lbs I started super low and slow at .5 mg for two weeks before moving up. Oct 4 310 lbs and december 17th 280lbs at 5 mg

nice post …
Half life is important to understand and this shows it clearly.
I personally started at 308lbs and starting dose of .5mg. Clear results from the start.. December 17th 280lbs at 5mg.

Not perfect experience though…i popped 10 lbs over Christmas and flatlined loss for about a month.

Three things happened that I can point to.
-Christmas I cheated for a week (I assume that was the weight gain)
-ipamorelin started dec 23
-Reta supplier changed dec 23

Now Jan 23 sitting at 283 and at 8 mg for second week straight.

I get the weight gain but that resulting “stall” still has me a little puzzled


Thanks for your info

Just upped to 10mg….its definitely been a different world on slower loss since Christmas ….although 30 lbs super quick is likely mostly water

Have new blood work coming In and as long as %fat is in downslope I am happy …

Thanks for the imput

 

[MFGamesta]

Hello,

I purchased Retatrutide and am currently going into my fifth week. I started at what’s considered the higher end of dosing and have gradually increased from there. My dosing schedule is listed below. So far, I’m honestly not feeling much of a response. I’m still able to eat normally, though I have noticed that my cravings are mostly gone and it’s been easier to eat clean. I do feel slightly fuller at times, but that’s about it. My girlfriend is following the same plan, and she has already lost 23 pounds, which makes me wonder if I might just be a non-responder. I’m feeling a bit underwhelmed and curious if anyone else has had a slower response or noticed that it took longer for things to really kick in.

Dosing schedule:

• Week 1: 2 mg
• Week 2: 3 mg
• Week 3: 3 mg
• Week 4: 3 mg
• Week 5: 4 mg

Thanks in advance for any shared experiences.

What are your numbers ? Age, weight, gender.

 

[gusterbuster]

Im gonna add that I've had a two bunk vials that came from arguably respectable vendors with janoshik testing. I looked up the test data on janoshik to verify no photoshop high jynx and they panned out.

From my understanding reta is more likely to misfold or some stuff way above my level of biochem than tirz and that doesnt show up on the testing. I know they were bunk as my heartrate started dropping, that minor skin feeling disappeared, hunger returned. Doubled dose and still nothing, new vial and back on track.

 

[Rp121]

The best way to visualize how your dosage reaches saturation, and what levels you're at and when, is with a plotter. You can plug in your dosage over the past 5 weeks , or project your dosage, and see what it looks like. https://glp1plotter.com/

This is a really underrated post and easy to miss! The plotter is great and yes, it gives a really good view of how much GLP-1 is in potentially in your system. I tried it and it was suprising. I'm in week 1 of my R journey and this has certainly stopped me from panicking (as I'm 'feeling' very little). I can also see why people titrate with unrealistic expectations and possibly overdosing.

 

[Chili777]

This is a really underrated post and easy to miss! The plotter is great and yes, it gives a really good view of how much GLP-1 is in potentially in your system. I tried it and it was suprising. I'm in week 1 of my R journey and this has certainly stopped me from panicking (as I'm 'feeling' very little). I can also see why people titrate with unrealistic expectations and possibly overdosing.

Glad to hear that and that was the intent. In our instant world, some things still take time. Give it a chance to build up and titrate slowly. I'm in week 16 and only bumped up at 4 week intervals, but I'm also a good responder. I'm down 50 lbs.

 

[jwilson1828]

UPDATE: Turns out this post was completely unnecessary 😅

Alright, I owe everyone an apology because this thread ended up being a total waste of your time — and that one’s on me. I was basing my entire opinion of my progress on how I felt and how I looked, instead of doing the obvious thing and actually stepping on the scale. The truth is, the scale and I haven’t been friends for a few years now, so I tend to avoid it about 99% of the time. I figured I’d just “know” if things were working based on appetite suppression, visual changes, or how my clothes fit.

Well… today I took my 6th injection, and something told me I should finally check the scale.

Turns out I’m down 24 pounds (11 kg).

Yeah. I felt pretty stupid immediately after seeing that number, considering I just made a whole post questioning whether this was even working. Clearly, it is working — just not in the way I expected it to.

What’s interesting is that I still don’t really feel strong appetite suppression at all. I can eat normally, and I don’t feel dramatically different day to day. That said, my cravings are mostly gone, I’m not constantly thinking about food, and it’s been much easier to eat clean without forcing it. I guess the changes were happening quietly in the background, even if I wasn’t consciously noticing them.

So yeah — lesson learned. Sometimes progress doesn’t “feel” dramatic, but the data doesn’t lie. Thanks to everyone who took the time to reply and share their experiences. Sorry again for the unnecessary panic post 😅

Just a general question... if you and scales haven't been 'friends' for a few years, how do you actually know your starting weight?

 

[Chili777]

Just a general question... if you and scales haven't been 'friends' for a few years, how do you actually know your starting weight?

I got the newest Renfo model when I started. If you don't track your weight, it's like driving in the dark without headlights.

 

[Thedooman445]

I wanted to give an update now that it’s been about four months — I officially hit my goal weight of 166 lbs (actually reached it about two weeks ago). I feel great overall and really happy with the results. I’ve since come off Reta and transitioned into a lean bulk phase. One thing worth noting is that I experienced zero side effects the entire time, even at a 10 mg dose, and I was able to eat pretty freely without issues. It almost feels like my body just tolerates higher doses well. I’ve noticed a similar pattern with AAS too. Overall, Reta definitely delivered for me, and I’ll 100% be using it again for my next cut.

 

[FlowerFairy]

I didn’t personally test the Reta, but I purchased it from a vendor listed under the Vendor Connections tab on this website. They provided Janoshik lab results for their batch. I don’t believe it’s fake, especially since my spouse struggled significantly with weight loss before and is now seeing noticeable changes. As for my part, I track my calories very carefully—I weigh everything in grams and stay consistent. I’m typically eating around 1,500–1,700 calories per day and getting approximately 180–200 grams of protein daily.

Never trust a vendor test. You don’t know that the test they posted is for the batch you received. You find others who bought from the same batch and do a group test so it’s affordable and you know what you’re getting.

Also, Reta doesn’t affect food noise like Tirz. It provides early satiety- in other words, eat a smaller meal and give it 10-15 minutes to see if you feel full before eating more. It seems to affect food noise at higher doses, but the satiety kicks in sooner.

 

[lessthanhalf]

UPDATE: Turns out this post was completely unnecessary 😅

Alright, I owe everyone an apology because this thread ended up being a total waste of your time — and that one’s on me. I was basing my entire opinion of my progress on how I felt and how I looked, instead of doing the obvious thing and actually stepping on the scale. The truth is, the scale and I haven’t been friends for a few years now, so I tend to avoid it about 99% of the time. I figured I’d just “know” if things were working based on appetite suppression, visual changes, or how my clothes fit.

Well… today I took my 6th injection, and something told me I should finally check the scale.

Turns out I’m down 24 pounds (11 kg).

Yeah. I felt pretty stupid immediately after seeing that number, considering I just made a whole post questioning whether this was even working. Clearly, it is working — just not in the way I expected it to.

What’s interesting is that I still don’t really feel strong appetite suppression at all. I can eat normally, and I don’t feel dramatically different day to day. That said, my cravings are mostly gone, I’m not constantly thinking about food, and it’s been much easier to eat clean without forcing it. I guess the changes were happening quietly in the background, even if I wasn’t consciously noticing them.

So yeah — lesson learned. Sometimes progress doesn’t “feel” dramatic, but the data doesn’t lie. Thanks to everyone who took the time to reply and share their experiences. Sorry again for the unnecessary panic post 😅

I managed to avoid the scales so thoroughly that I got from size 7xl to xl or 2xl before I was prepared to even step on them, just too horrified to see the actual numbers, and even then was a bit disappointed to see I was still 115kg and had a long way to go, so clothes size can be used to track progress but is not exactly precise.

 

[BNLFL]

I managed to avoid the scales so thoroughly that I got from size 7xl to xl or 2xl before I was prepared to even step on them, just too horrified to see the actual numbers, and even then was a bit disappointed to see I was still 115kg and had a long way to go, so clothes size can be used to track progress but is not exactly precise.

That's my wife. If she weighs herself, she doesn't tell me. I do Tues and Friday on the Repho. I know she's losing because she's wearing clothes she hasn't worn in years. I was funny as hell the other day. She was getting something out of the fridge, and her shorts just fell down.

 

[Juliana]

I've been using Reta since November 2025. Wasn't impressed with it until the last two months I have dropped 3.3kg March and 3.6Kg April. Been on tirzepatide from July 2025 and swapped to Reta in November starting weight 111.3kg now 93.4kg

Forgot to mention I've increased my dose from an initial 1mg to 6mg twice a week so 12mg per week.

 

[Glplover121]

Hello,

I purchased Retatrutide and am currently going into my fifth week. I started at what’s considered the higher end of dosing and have gradually increased from there. My dosing schedule is listed below. So far, I’m honestly not feeling much of a response. I’m still able to eat normally, though I have noticed that my cravings are mostly gone and it’s been easier to eat clean. I do feel slightly fuller at times, but that’s about it. My girlfriend is following the same plan, and she has already lost 23 pounds, which makes me wonder if I might just be a non-responder. I’m feeling a bit underwhelmed and curious if anyone else has had a slower response or noticed that it took longer for things to really kick in.

Dosing schedule:

• Week 1: 2 mg
• Week 2: 3 mg
• Week 3: 3 mg
• Week 4: 3 mg
• Week 5: 4 mg

Thanks in advance for any shared experiences.

I’m pretty similar, I did 2 weeks on 2mg and then 2 weeks on 3mg and not having any noticeable affects. The scales haven’t moved although I am training and watching calories. I have been on Tirz previously so think I’m comparing the two as on that my appetite was completely crushed and I lost a considerable amount of weight! Hoping that as the weeks progress Reta will start to kick in… if not back to Tirz I go 🤣