What peptides will you never try?

randompersonrandom said:
I've tried tirz, reta, survo, KLOW, Epitalon, NAD+ (never again), SS-31, and MOTS-C (never again).

I will keep using some glp1 or other for forever, and intend to keep running the KLOW and Epitalon periodically, and am open to SS-31 occasionally.

Everything else, I believe is either unnecessary, likely snake oil, or dangerous. I've reached the end of my own personal "inject all the things and see what happens" journey.
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If you don't mind me asking, what did you hate about nad+ and mots-c? I've been looking at these for a minute.
 
Calm Logic said:
For the people I know, KPV is their favorite in KLOW. It's at least more feelz for them (in helping their pain), compared to BPC and the rest in KLOW.
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I don't have any long-term pain, but I really do think KLOW makes my skin look a little better. I keep meaning to try a quick pin of KPV when I'm having a migraine (my migraines are weather-related, silent or painless, and deeply unpleasant because I get all symptoms except the pain) to see if it helps, but unfortunately during a migraine, I'm too dumb and confused to remember that I meant to try that.
 
AlexSilver said:
I agree. But then, I never thought I would do this either (sub-q). And those vitamin B shots are starting to look really appealing.
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Same same. I have never been a fan of being injected in general. Now look at me, a regular injector lol
 
randompersonrandom said:
I don't have any long-term pain, but I really do think KLOW makes my skin look a little better. I keep meaning to try a quick pin of KPV when I'm having a migraine (my migraines are weather-related, silent or painless, and deeply unpleasant because I get all symptoms except the pain) to see if it helps, but unfortunately during a migraine, I'm too dumb and confused to remember that I meant to try that.
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I just purchased a pen so I can try KPV during my next migraine. The less things I have to mess with during an attack, the better. Fingers crossed we get relief, desperate at this point for anything that might help 😅
 
randompersonrandom said:
I've tried tirz, reta, survo, KLOW, Epitalon, NAD+ (never again), SS-31, and MOTS-C (never again).

I will keep using some glp1 or other for forever, and intend to keep running the KLOW and Epitalon periodically, and am open to SS-31 occasionally.

Everything else, I believe is either unnecessary, likely snake oil, or dangerous. I've reached the end of my own personal "inject all the things and see what happens" journey.
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Curious what you didn't like about MOTS-C. I am specifically planning to add this one asap because I have family members with bone density issues (and I have had three joint replacements).
 
RuhRoRaggy said:
PT-141
I’m not even sticking a needle in YOUR dick🤣🤣🤣
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So...we need the tea. I got my mug at the ready. What is this dick-tide malarkey you speak of?
the addams family 90s GIF
 
randompersonrandom said:
NAD+ did nothing positive that I could perceive, and it hurt and was a lot of volume, which grosses me out. MOTS-C hurt, MAY have granted some energy, but hurt and left lumps that remained for months (one of which is still there.)

I'll tolerate some hurt because I really do believe KLOW is doing SOMETHING. But if it hurts and doesn't seem to do anything for me, no thanks. And the MOTS-C leaving those for-way-too-long lumps was what made "and there's some risk to this" real for me.
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Before I started buffering, I would get hard indurations from MOTS-C (and GHK-Cu) too. I am currently using dry-brushing, massage with arnica gel, red + near-IR light, and BPC/TB injected nearby to reduce the size of the fibrotic tissue. It's helping, but it's a slow process. If I didn't confound the variables...I'd actually know which one was helping. Maybe one of these methods can help you as well. 🙂
 
DunningKruger said:
Before I started buffering, I would get hard indurations from MOTS-C (and GHK-Cu) too. I am currently using dry-brushing, massage with arnica gel, red + near-IR light, and BPC/TB injected nearby to reduce the size of the fibrotic tissue. It's helping, but it's a slow process. If I didn't confound the variables...I'd actually know which one was helping. Maybe one of these methods can help you as well. 🙂
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Yeah, I really think that last lump will eventually heal on its own; and even if it didn't, it's so small at this point that it's not causing me any real issues. But I'll definitely never touch MOTS-C (which was buffered) again, or anything but KLOW that's known for ISR's. And I honestly feel like I've tried all of the low-risk peps that I believe might do something, and I'm very happy with just Klow's components, epitalon, and SS-31. All three of those I know work fine for me, and I believe all three of them DO something.
 
What a good idea for a " post"!!!! One day, I made a list of every peptides that I read here and I google each of them.

It's kind of a new passion for me! My strange addiction, like the old reality show ( but I don't eat my sofa filling and I don't eat Ajax).

So, as a woman who want to be thin, the thing that I WONT try, its IPAMORELIN and all peptide who promote growing hormones and muscle mass growing. Maybe I am wrong, but I prefer loosing weight and after building my muscles?

I am willing to try peptides who help my skin, wrinkles, hairs.

And you?
 
For me reta and 5 amino 1mq subcu so far, i want to try KPV by itself, heard good things about ss-31 andepitalon but have tried those yet. Definitely staying away from those that cause angiogenesis
 
AlexSilver said:
From my notes:
LL37 - Never use - works as described but also causes massive inflammation on several levels, definitely causes and/or accelerates tumor growth, promotes histamine release, and exacerbates arthritis and skin conditions like psoriasis and eczema.
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This sounds absolutely horrible
 
Brouette said:
So, as a woman who want to be thin, the thing that I WONT try, its IPAMORELIN and all peptide who promote growing hormones and muscle mass growing. Maybe I am wrong, but I prefer loosing weight and after building my muscles?
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I think that assumption is too simplistic. Wanting to be “thin” is not the best frame; preserving a lean, strong physique is a better goal during weight loss.

Peptides associated with growth signalling do not automatically make a woman bulky. That depends on the full context: dose, diet, training, genetics, and total energy balance.

If you’re on a GLP, I’d actually be more concerned about muscle loss than “bulking.” In that context, a GH secretagogue may help support lean mass retention, especially if protein intake is below 1g/lb of ideal body weight and resistance training is not in place.

I can say from personal experience that GH secretagogues do not automatically make a woman bulky. I eat 80–120 g of protein daily, have taken Tesa (1 mg)/Ipa (200 mcg) nightly this past quarter, and have been very satisfied with the results—lean, athletic, and far from bulky.

Included: last week’s DEXA and my smart scale data as a real-world example.
 

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DunningKruger said:
I think that assumption is too simplistic. Wanting to be “thin” is not the best frame; preserving a lean, strong physique is a better goal during weight loss.

Peptides associated with growth signalling do not automatically make a woman bulky. That depends on the full context: dose, diet, training, genetics, and total energy balance.

If you’re on a GLP, I’d actually be more concerned about muscle loss than “bulking.” In that context, a GH secretagogue may help support lean mass retention, especially if protein intake is below 1g/lb of ideal body weight and resistance training is not in place.

I can say from personal experience that GH secretagogues do not automatically make a woman bulky. I eat 80–120 g of protein daily, have taken Tesa (1 mg)/Ipa (200 mcg) nightly this past quarter, and have been very satisfied with the results—lean, athletic, and far from bulky.

Included: last week’s DEXA and my smart scale data as a real-world example.
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Thank you for you answer! It complete, and you giving me the idea to try something new! Thank you again !!!
 
chmuse said:
Would it work differently?
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Not in a good way, lol.

I'm surprised I tried PT-141 at all after watching the episode of The Pitt where the nurses had to manage priapism in a hands-on way. But some bros would like the attention, I guess, at least from certain nurses.

The standard dosage of 1.75 mg is intended for "premenopausal women with HSDD (Hypoactive Sexual Desire Disorder)" and seems too high for most men, IMHO.

I tried a full dose the first time, but I only microdose now, mostly for a mood boost:
Gemini said:
PT-141 Protocol Evaluation: Gender Response & Dosing Comparison

FeatureClinical Dose (1.75 mg)Microdose (0.5 mg – 1.0 mg)
Target PopulationFDA-approved for premenopausal Women (HSDD).Preferred by Men and sensitive responders.
Primary MechanismHigh-level CNS receptor saturation.Threshold activation; avoids "over-stimulation."
Response (Men)Often too intense. Prolonged erections (priapism risk).Natural responsiveness. Better control/timing.
Response (Women)Standard for HSDD; triggers significant arousal signal.May be too subtle for some; depends on baseline drive.
Side Effect ProfileHigh Nausea/Flushing. Can last several hours.Minimal Nausea. Maintains the "mood boost."
Dopamine/MoodMasked by physical distress or "flu-like" feeling.Clean mood lift. Focus, motivation, and "wanting."
BP / CardiovascularNotable transient spikes in blood pressure.Negligible impact for most healthy users.
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