Will Cagri-Sema Be The New Hotness?

[dionysos]

Are we wasting our time with Tirzepatide and Retatrutide?

Express your opinions please!

CagriSema Phase Three Studies are in progress right now.

A Phase Two Study showed the amazing CagriSema results I've quoted here:

"a fixed-dose combination therapy of 2.4mg semaglutide with 2.4mg cagrilintide"
... caused a decrease in bodyweight at Week 32 of treatment by 15.6% ...

... Zepbound caused a bodyweight decrease at 72 weeks of 15% from baseline at the lowest dose, and 20.9% at the highest dose (15mg)...

... CagriSema is likely to cause a bigger change in body weight... than even the highest dose of Zepbound ...

Link to CagriSema Phase Two Study:
Novo Nordisk launches trial of pipeline drug CagriSema versus newly approved Zepbound

 

[1HandLionTamer]

Not every RS responds the same, benefits and side effects vary dramatically. Good that more options are available especially if they target different receptors. With all the money being exchanged for these medications it is in their best interest to keep finding better mixes, weight loss and muscle preservation etc.

 

[Huckleberry1]

Are we wasting our time with Tirzepatide and Retatrutide?

Express your opinions please!

CagriSema Phase Three Studies are in progress right now.

A Phase Two Study showed the amazing CagriSema results I've quoted here:

"a fixed-dose combination therapy of 2.4mg semaglutide with 2.4mg cagrilintide"
... caused a decrease in bodyweight at Week 32 of treatment by 15.6% ...

... Zepbound caused a bodyweight decrease at 72 weeks of 15% from baseline at the lowest dose, and 20.9% at the highest dose (15mg)...

... CagriSema is likely to cause a bigger change in body weight... than even the highest dose of Zepbound ...

Link to CagriSema Phase Two Study:
Novo Nordisk launches trial of pipeline drug CagriSema versus newly approved Zepbound

Except that suggested dose of cagri is 0.3-0.6

 

[dionysos]

Except that suggested dose of cagri is 0.3-0.6

Please say more about this and why it is significant to us.

 

[Batscout]

I am involved with healthcare and a lawyer. If anyone needs assistance with finding case law, codes, regs, or medical research white papers, I have access to a few libraries and may able to help.

 

[astroman]

Reviving this thread. Anyone give Cagri any further testing?

 

[amynurse]

Reviving this thread. Anyone give Cagri any further testing?

My RS runs it weekly @ 500mcg. Runs concurrently with 5mg tirz. Increase in weight loss noted the day after each cagri injection. Only SE noted is nausea.

 

[astroman]

My RS runs it weekly @ 500mcg. Runs concurrently with 5mg tirz. Increase in weight loss noted the day after each cagri injection. Only SE noted is nausea.

You’ve just now made me realize how low the dosage is. My RS is only on week 2 of T and have found the next day and two days after shot day is notably higher in weight drops. I wonder if it’s similar across all GLP’s

 

[amynurse]

You’ve just now made me realize how low the dosage is. My RS is only on week 2 of T and have found the next day and two days after shot day is notably higher in weight drops. I wonder if it’s similar across all GLP’s

Yeah, starting dose of cagri is 300mcg. I started at 250mcg. Had strong suppression, but it faded after only 48 hours. So far just that small bump extends the effects another 48 hours out. Then the tirz covers on the back end.
I've noticed weight drops are quicker after cagri. My RS doses tirz on Saturday, and that drop isn't until Monday or Tuesday. Weird.

 

[rkl123]

So tirz>sema.
Cagri-sema> Tirz.

Do Cagri and Sema have any special interaction? If not it would seem to imply that the combo of Cagri and Sema together are a pharmaceutical quirk: that instead the right move would be Cagri-tirz

 

[amynurse]

So tirz>sema.
Cagri-sema> Tirz.

Do Cagri and Sema have any special interaction? If not it would seem to imply that the combo of Cagri and Sema together are a pharmaceutical quirk: that instead the right move would be Cagri-tirz

Cagri and Sema were designed to be given together, by Novo Nordisk. Cagri-tirz can be done in a research capacity, but NN and EL would rather burn at the stake than let them be combined pharmaceutically

 

[astroman]

Yeah, starting dose of cagri is 300mcg. I started at 250mcg. Had strong suppression, but it faded after only 48 hours. So far just that small bump extends the effects another 48 hours out. Then the tirz covers on the back end.
I've noticed weight drops are quicker after cagri. My RS doses tirz on Saturday, and that drop isn't until Monday or Tuesday. Weird.

That’s so interesting, especially since there’s not a big drop in dosage level within the system until day 5-6. On week one of 2.5T, my RS had SIGNIFICANT suppression, but not much this week. Thought maybe adding Cag could help on the back end, without increasing T dosage so soon.

 

[astroman]

Cagri and Sema were designed to be given together, by Novo Nordisk. Cagri-tirz can be done in a research capacity, but NN and EL would rather burn at the stake than let them be combined pharmaceutically

I’ve recently heard of CagriSema (not named by yours truly). I would like to see some studies in that combo in comparison to just T or the CT combo.

 

[amynurse]

That’s so interesting, especially since there’s not a big drop in dosage level within the system until day 5-6. On week one of 2.5T, my RS had SIGNIFICANT suppression, but not much this week. Thought maybe adding Cag could help on the back end, without increasing T dosage so soon.

My RS had a similar outcome the second and third week. First week was killer....but RS has a fast metabolism. 5mg seems to be a good spot for now, we'll see in a few more weeks. The cagri absolutely helps on days 5-7 of tirz!

 

[amynurse]

I’ve recently heard of CagriSema (not named by yours truly). I would like to see some studies in that combo in comparison to just T or the CT combo.

There are preliminary reports out, I'll see if I can find one. So far, CS is just slightly out-performing tirz.

 

[astroman]

There are preliminary reports out, I'll see if I can find one. So far, CS is just slightly out-performing tirz.

I read somewhere CS had results closer to 30% rather than 15 and 20 for S and T, respectively.

 

[amynurse]

According to a Phase II trial of CagriSema (NCT04982575), the combination therapy caused a decrease in bodyweight at Week 32 of treatment by 15.6% from baseline. On the other hand, in the SURMOUNT-1 Phase III trial (NCT04184622), Zepbound caused a bodyweight decrease at 72 weeks of 15% from baseline at the lowest dose, and 20.9% at the highest dose (15mg). These results suggest that CagriSema is likely to cause a bigger change in body weight from baseline than even the highest dose of Zepbound, in a fixed amount of time.

 

[amynurse]

According to a Phase II trial of CagriSema (NCT04982575), the combination therapy caused a decrease in bodyweight at Week 32 of treatment by 15.6% from baseline. On the other hand, in the SURMOUNT-1 Phase III trial (NCT04184622), Zepbound caused a bodyweight decrease at 72 weeks of 15% from baseline at the lowest dose, and 20.9% at the highest dose (15mg). These results suggest that CagriSema is likely to cause a bigger change in body weight from baseline than even the highest dose of Zepbound, in a fixed amount of time.

Novo Nordisk launches trial of pipeline drug CagriSema versus newly approved Zepbound

On 8 November, Eli Lilly received FDA approval for Zepbound (tirzepatide), its glucagon-like GLP-1/GIP dual agonist for patients with obesity.

www.clinicaltrialsarena.com

 

[rkl123]

Cagri and Sema were designed to be given together, by Novo Nordisk. Cagri-tirz can be done in a research capacity, but NN and EL would rather burn at the stake than let them be combined pharmaceutically

Sema came out long ago. Was cagri truly designed for a special synergy...or was it "sema is being out competed, cagri looks decent and hits an independent receptor, let's try them together to have something competitive?"

 

[astroman]

Sema came out long ago. Was cagri truly designed for a special synergy...or was it "sema is being out competed, cagri looks decent and hits an independent receptor, let's try them together to have something competitive?"

But truthfully, is that bad business? I’d do it.

-Astroman, MBA