How has retatrutide affected your heart rate?

I've been on it 5.5 weeks (1mg/week, split into two doses for the first 4.5 and upped to 1.4mg/week on Tuesday) and no appreciable impact to HR. I do heavy lifts 4 days/week and one long distance hike per week (and have for the past 10 years) and HR has only gone up very slightly. RHR is typically between 48-52 bpm and has been around 54-55 since starting, and my max HR during lifts/hiking went from 165 to 169-170bpm.
 
I haven’t noticed anything through feelings, but it’s been tracked.

I started Tirz in December and Reta in January. Rapid titration on Reta. My 5 year average based on Apple Watch is 63 bpm.

Unless you have issues with the heart or a RHR baseline >~80, Reta gets too much conversation about elevated heart rate.

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I started reta on march 24, we can clearly see the uptrend since. But i dont "feel" it on my day to day.
 

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rixsternaz said:
Your resting HR is low... are you an athlete or was this taken during sleep? Looks like reta placed you in a normal HR range now, lol.
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My HR always been slow... my apple watch was sending me alerts all the time for "going under 40 bpm" during the night. It's stopped when i began reta. I like to think i'm an athlete 🤔🤷‍♂️😂
 
Galapagosfit said:
My HR always been slow... my apple watch was sending me alerts all the time for "going under 40 bpm" during the night. It's stopped when i began reta. I like to think i'm an athlete 🤔🤷‍♂️😂
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I was having the same problem and had to turn those alerts off because they were driving me crazy. Mine still hovers between 40 and 50 BPM for resting after almost 6 weeks on Reta. Currently taking 2mg/wk. IMG_0786.webp
 
Most people do not notice any obvious effects, but there is a measurable increase on reta, that is larger than for the other GLP's.

I think the only time it is going to matter is if it increases heart rate a lot , like more than 15 or so, which is not common but possible, if you have heart disease, in which case reta might not be the best choice, and tirz might be a better option at least until there is more research on reta, and if you get anxious easily, and notice palpitations as part of that anxiety. Given the question, I do wonder if this is the case. Usually the heart rate increase trends down towards normal over months. If you do get anxiety or unpleasant palpitations you can always drop the dose or stop it, and switch to tirz instead, which also increases heart rate but less than reta.

If you have diagnosed panic disorder, I would pick tirz, it is not a known documented interaction, but I have seen 2 or 3 people on this forum with panic episodes from reta, so while rare and not documented in the scientific literature as far as I know, it is possible it could trigger them in those with the right susceptibility.
 
Yes, it did and quite significantly.
I have been on Reta for 3 months and I went from 58-60 BPM at rest to 71-73 (measured with the Oura ring). I am worried that I'm putting my heart under a lot of stress and considering switching.
 
Worked my way up from 2mg to 4 for a few months and now I’ve been on 6 for the last few weeks, nothing noticable for me
 
I have no raised RHR at all on Reta, currently at 2mg every 5 days, which I will be bumping up to 3mg/week, since 2mg every 5 days equals to 2.8mg/week
 
390120 said:
Worked my way up from 2mg to 4 for a few months and now I’ve been on 6 for the last few weeks, nothing noticable for me
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See below.
Godenzoon14 said:
I have no raised RHR at all on Reta, currently at 2mg every 5 days, which I will be bumping up to 3mg/week, since 2mg every 5 days equals to 2.8mg/week
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Are you guys guessing or measuring with a device?
 
woundcarping said:
My guess is they don’t use a continuous tracker like a watch or ring.

I’m glad I’ve got years of baseline from my watch. Feels wise I wouldn’t notice the increase.
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Same from 3.5 years ago after I spent 3 weeks in the hospital with pneumonia. Been checking my O2/HR with a finger sensor and BP with a cuff.
 
Atlanatpr said:
I’ve read in some places online that it can really increase your heart rate a lot, and it can feel uncomfortable. I’m curious about what everyone has noticed.
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Only two weeks in on 1mg, and no difference to me. I regularly walk 5 miles and do weights at the gym 4x a week. Resting heart rate at 62 still.
 
It made me tachycardic, even during sleep. Though, it never felt uncomfortable. I think discomfort is often tied to how tuned in you are to bodily sensations. If you're highly attuned (or prone to anxiety), you might over-interpret it; I noted it as data.

That said, I did run an ECG and a 24-hour Holter to confirm that it was not causing damage. I posit that my heart's glucagon receptors are either more plentiful, or simply more responsive to the cyclic AMP signalling that glucagon triggers.
 
My RHR rose from about 60 to 70 on 2mg/wk. Im at 4+mg/wk right now on my 2nd cycle and it's actually back down in the 60s. Cardio seems to get my heart rate up faster though.
 
I had three events of tachycardia after light exercise commuting to work. So I stopped. Used Apple Watch for three years before. Never an alert before or after I stopped Reta. I had only a handful weeks of use and started and stayed at 1mg. Considering starting again if the weight starts going up or trying tirz or ozempic.
 
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