📌Is 🇷🇪🇹🇦 supposed to be this way⁉️❓

But has your waistline slimmed down? I haven't lost weight either but my pants feel looser. I've just been working out every day since starting reta so muscle gains are offsetting my fat loss.
 
Stay at 1.5 or 2mg for 4 weeks. It needs to build up. What's with all the BS in the tread title?
 
GLP1Pharmacist said:
Takes several weeks to build up in system, best to keep doses the same for a month at a time.
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Half life is 6 days if I recall correctly. So a given dose actually takes 4 weeks to fully build up. You can look at how test e builds up by comparison because it has a similar half life. Google search will show the graphs. When people rush it, some end up wrecking their sleep for a few weeks with a racing heart. And the only thing that works instantly is DNP which is poison so I would avoid that:::
 
My advice is to titrate slowly. I have been at 5mg for 2 weeks and I feel like absolute SHIT now. I haven't been able to eat hardly at all this week. I thought it was a dehydration issue at first but the extra fluids and salt didn't help. I think I should have stayed at 4mg for longer. I'm so stupid.
 
Gt3294a said:
Half life is 6 days if I recall correctly. So a given dose actually takes 4 weeks to fully build up. You can look at how test e builds up by comparison because it has a similar half life. Google search will show the graphs. When people rush it, some end up wrecking their sleep for a few weeks with a racing heart. And the only thing that works instantly is DNP which is poison so I would avoid that:::
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You'know that math always boggled my noggin.
 
Smiter said:
You'know that math always boggled my noggin.
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Just err on the side of extra test to account for possible miscalculation and less on Reta for the same and life works out just great. That’s how I do my rounding.
 
Before even considering messing with the standard dosing arrangement, you need to be sure you understand the pharmacokinetics of the drug. GLP's are totally different to just about any other drugs. They take around 24h to be absorbed and get to peak drug levels in the blood and the half life is 6 days for reta, so it takes 6 days for that peak to drop by half. The amount in your system will continue to increase over 4 weeks, which is why it is recommended to increase doses every 4 weeks.
GLPplotter is a good way to understand what is going on as it shows you this in a graph of blood levels over time.
The issue with increasing doses more often or by a larger amount is side effects. Most people will get some , most common are nausea, vomiting , diarrhoea or constipation and with reta skin sensation weirdness. Side effects typically are worst at 2-4 months after starting with dose increases at around 4-8mg/w and usually very slowly improve.
Because of the long half life if you do get unpleasant side effects like vomiting, it might improve over a few days, but if you are unlucky you could be puking for a week, and when that happens there is a good chance you will need medical treatment.
Side effects or having them get worse are always a risk with any dose increases, but you are more likely to get more severe or prolonged ones if you push dose increases faster, and because of the slow build up of levels over 4 weeks , it might become a problem weeks after a dose increase, which is not intuitively obvious. And individual responses to the hunger reducing effects and the side effects are very variable, which is the reason for the slow careful dose increases plan.
 
lessthanhalf said:
Before even considering messing with the standard dosing arrangement, you need to be sure you understand the pharmacokinetics of the drug. GLP's are totally different to just about any other drugs. They take around 24h to be absorbed and get to peak drug levels in the blood and the half life is 6 days for reta, so it takes 6 days for that peak to drop by half. The amount in your system will continue to increase over 4 weeks, which is why it is recommended to increase doses every 4 weeks.
GLPplotter is a good way to understand what is going on as it shows you this in a graph of blood levels over time.
The issue with increasing doses more often or by a larger amount is side effects. Most people will get some , most common are nausea, vomiting , diarrhoea or constipation and with reta skin sensation weirdness. Side effects typically are worst at 2-4 months after starting with dose increases at around 4-8mg/w and usually very slowly improve.
Because of the long half life if you do get unpleasant side effects like vomiting, it might improve over a few days, but if you are unlucky you could be puking for a week, and when that happens there is a good chance you will need medical treatment.
Side effects or having them get worse are always a risk with any dose increases, but you are more likely to get more severe or prolonged ones if you push dose increases faster, and because of the slow build up of levels over 4 weeks , it might become a problem weeks after a dose increase, which is not intuitively obvious. And individual responses to the hunger reducing effects and the side effects are very variable, which is the reason for the slow careful dose increases plan.
Click to expand...
The half-life math is what got me circumspect. Yes, the amount of the drug in the system reduces by half every 6 days. So, 1mg becomes 500mcg in 6 days, 250mcg in 12 and so forth. Dosing once every 7 days with 1 mg will mean that on day 30, there will be 1.41mg of drug in the body, using the formula Remaining=1 mg×(1/2)^days elapsed/6.

It's using this math that I thought of raising the dose to 1.5mg.
 
Smiter said:
I took my 2nd dose at 1.5mg, first one was 1mg. So far, no real weight loss or substantial appetite suppression except on the day of dosing. Am I doing something wrong? The only thing I have lost is sleep. I'm wondering if I should increase the dosage. 🤔 👍🫰🤏🧪
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I'm only on the 4th day of my first 1mg dose and I'm not feeling any appetite suppression.

But what I am experiencing is this weird ability to distinguish want from need.
I keep trying to debate with myself, how much of this is the Reta talking and how much of it is my mind talking, and then I remember that Reta can make you change the way you think like that and suddenly I don't know what's real anymore.

An exaggeration obviously, but something has definitely given me the ability to differentiate want from need and that has pretty much eliminated snacking.
 
UnusualLLama said:
I'm only on the 4th day of my first 1mg dose and I'm not feeling any appetite suppression.

But what I am experiencing is this weird ability to distinguish want from need.
I keep trying to debate with myself, how much of this is the Reta talking and how much of it is my mind talking, and then I remember that Reta can make you change the way you think like that and suddenly I don't know what's real anymore.

An exaggeration obviously, but something has definitely given me the ability to differentiate want from need and that has pretty much eliminated snacking.
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I want it...hand it over
 
Smiter said:
Just my luck. Is my reta contraband or fake?
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It's a genuine question, there's risk in the grey market.

You'll never know for certain unless you get it tested yourself or start to notice the effects.


I did my research here before taking that first plunge, can't discuss sources but looked for one with no controversial issues mentions and good reviews but at the end of the day how do I know they slapped the right label on a vial?

It could be you having the flu is messing with things a bit but as others have said I'd stick it out a bit, give it a month at least.

You're sure you're dosing it correctly as well, right?
 
UnusualLLama said:
It's a genuine question, there's risk in the grey market.

You'll never know for certain unless you get it tested yourself or start to notice the effects.


I did my research here before taking that first plunge, can't discuss sources but looked for one with no controversial issues mentions and good reviews but at the end of the day how do I know they slapped the right label on a vial?

It could be you having the flu is messing with things a bit but as others have said I'd stick it out a bit, give it a month at least.

You're sure you're dosing it correctly as well, right?
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the prob is that this was a single vial from a us seller
 
Smiter said:
The half-life math is what got me circumspect. Yes, the amount of the drug in the system reduces by half every 6 days. So, 1mg becomes 500mcg in 6 days, 250mcg in 12 and so forth. Dosing once every 7 days with 1 mg will mean that on day 30, there will be 1.41mg of drug in the body, using the formula Remaining=1 mg×(1/2)^days elapsed/6.

It's using this math that I thought of raising the dose to 1.5mg.
Click to expand...
Drug levels do not go down in a linear fashion , trying to work it out without a graph is almost impossible. I had to hand draw graphs of ozempic levels to try to work it out before I knew places like this forum existed and other people had already worked it all out, so not sure that math is technically correct, but my pharmacology is pretty rusty, glp1plottter is much easier.
 
lessthanhalf said:
If maths is not your forte GLP plotter is a really good idea, understanding this bit makes understanding what is going on with effects and side effects over time much easier.
glp1plotter.com

GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator

Plot graphs and calculate levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) based on dose & half-life.
glp1plotter.com glp1plotter.com
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That GLPLOTTER apparently uses the same formula. On the 1st of June, it shows 1.41mg predicted amount when I input the same details as above.
 

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UnusualLLama said:
I'm only on the 4th day of my first 1mg dose and I'm not feeling any appetite suppression.

FIRST doses are not designed to be effective long term for most. The first months of any GLPs are designed to test your ability to tolerate and allow body to get used to it. Luckily most get some clinical benefit even early on. Stop over thinking, go month by month, go low and slow with dose, for most it took decades to be fat, take time to lose it. This is the healthiest and safest way.
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