After 2 years on Tirz where to go next? Elora or Maz?

Gwynhwyfar

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I startet Tirz this day 2 years ago. I lost around 120 lbs on it and I´m very happy. Was 1 year on 15mg (original stuff from the pharmacy) and on a stall since Dec 2025. I´m not a weight lifting person, I´m a swimmer and do 6 days a week 2 or 3 KM. I want to loose 60 more pounds to get to a normal weight range. I still have 48 % body fat. I started Reta 8 weeks ago and titrated Tirz down. I´m on 7.5 mg Tirz now and on 4mg Reta. But nothing happened so far. Cravings as crazy in the evening looking for snacks and into the fridge... saturday I added 0.25mg Cagri to get some suppression, but I don´t feel anything (like I felt in the beginning with Tirz).
Now I´m thinking, if Eloralintide is a better choice? Or Madzdutide? To get back on track and hit my calorie goal.
 
First of all, congratulations on the huge weight loss. If you were on 15mg Tirz and now only 7.5mg T and 4mg Reta, you will be hungrier than when you were on 15mg Tirz. I've found that R doesn't do much for appetite suppression and for myself, I was hungrier on R than without.

I think an ideal option would be going higher on T and stacking a little bit of Reta for the glucagon effect.

For cagri, wait it out for a full week and then try going up to 500mcg. It was kind of a slow burner for me.
 
Nope, I wanted to change to Reta, because of the benefits on loosing belly fat (that´s where it is !)
So, I moved from Tirz to Reta.

First month - I was pinning 7.5mg Tirz and three days later 4mg Reta. (did them both on same day the very first time and that was a huge mistake lmao.)

Second month - I went to 5mg Tirz and 8mg Reta. I started to have a lot of dizzy spells - at the gym, at work, anytime I had to change elevation (squat and then stand up.) Plus, I was having horrible food aversion. I had to force myself to eat even when I knew I needed it.

I got rid of the Tirz two weeks into my second month titrations. I just took it out. I kept the Reta at 8mg for six weeks then I went up to 10mg. I get full fast but still have a few times when I have to force myself to eat - usually in the morning. For lunch, dinner, or a random daytime snack, I'm okay. I get full a lot faster, too.

Kudos on your weight loss journey! Glad to know you're being active and going after your goals. Just sharing my experience in the hopes that it helps ya.
 
There is still a good chance reta will work for you once you get it to 12mg, but given how much weight you have lost already and the fact that you had stalled for quite a while on 15mg of tirz, it is not likely to be enough to cause a lot of extra weight loss, but at least should stop weight regain, which is really just as important. Doses above 12mg of reta might be worth considering if side effects allow it.

Either cagri or eloralintide are the best add on options, elora has less research so far but looks like it has more weight loss and less side effects than cagri so might be better, but if you have already started low dose cagri it might be worthwhile pushing the dose up slowly to see how well you tolerate it, and swap to elora if side effects are a problem.

It is a pity the only research on combo GLP's in humans so far is cagrisema, as it was fairly good for weight loss, but did not add as much extra weight loss as they were hoping for and with sema had quite high rates of side effects.

The situation you are in has not really been addressed by the research yet. My way of thinking is that degree of obesity is really quite bad for your health and any possible risks from combination or high dose GLP therapies are very unlikely to be higher than the risks of not treating the obesity.

I only started GLPs after losing most of the weight currently on tirz15mg/reta5mg/cagri0.5mg and down 55% at 64kg from 145kg. But the drugs help a lot with controlling hunger and I think there is a good chance I can keep the weight off this time.
 
I think you should do reta plus elora. Or just reta first and see how it goes. Then reta and elora if needed/plateau. That combo is supposed to be really good.
 
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It sounds like its time to focus more on calories and less on meds. You have been stalled for months which means you have not been eating at a deficit. Logging calories and loading up on less calorie dense food makes more sense than just trying to add more meds. They are best used to help you move to eating a healthier diet rather than as the primary way to lose weight.

You are very active which is awesome and something a lot of people struggle with. You likely feel that your diet has been good but the lenght of your stall means that you are definitely still consuming too many calories. I would highly recommend a calorie tracking app and rigorous logging; really look at what you are putting in and don't just use their suggestions, they have been shown to be wildly off.

I understand looking for that appetite suppression and hopefully you can get that back but in the meantime, I would suggest really looking for less calorie dense foods and focusing on protien and overall volume. That should help some.
 
I second @lessthanhalf about getting Reta on up and consider going past 12mg as sides allow. I went from 5mg of Tirz to higher levels of Reta quickly with minimal fuss.

There’s not much research yet, but Elora’s buzz sounds like what you’re looking for.

How are your sides on Tirz and now Reta/Cag?


It sounds like its time to focus more on calories and less on meds…

Great point.
 
I second @lessthanhalf about getting Reta on up and consider going past 12mg as sides allow. I went from 5mg of Tirz to higher levels of Reta quickly with minimal fuss.

There’s not much research yet, but Elora’s buzz sounds like what you’re looking for.

How are your sides on Tirz and now Reta/Cag?




Great point.
Sides were little on Tirz some nausea and Sometimes diarrhea. Once a week or so. But all this sides disappeared completly in december, when mounjaro stopped working for me. Now I don't feel anything at all. Always hungry, cravings like never before and never feeling full. It's worse than before I started Tirz.
 
It sounds like its time to focus more on calories and less on meds. You have been stalled for months which means you have not been eating at a deficit. Logging calories and loading up on less calorie dense food makes more sense than just trying to add more meds. They are best used to help you move to eating a healthier diet rather than as the primary way to lose weight.

You are very active which is awesome and something a lot of people struggle with. You likely feel that your diet has been good but the lenght of your stall means that you are definitely still consuming too many calories. I would highly recommend a calorie tracking app and rigorous logging; really look at what you are putting in and don't just use their suggestions, they have been shown to be wildly off.

I understand looking for that appetite suppression and hopefully you can get that back but in the meantime, I would suggest really looking for less calorie dense foods and focusing on protien and overall volume. That should help some.
I was tracking the whole time and it was no Problem to stay at 1300 cal a day and hit my Protein Goal. But now I'm so crazy hungry craving for chocolate and snacks like never did before! And I don't know, why it was 18 months easy to keep everything on track and now Not?
 
I was tracking the whole time and it was no Problem to stay at 1300 cal a day and hit my Protein Goal. But now I'm so crazy hungry craving for chocolate and snacks like never did before! And I don't know, why it was 18 months easy to keep everything on track and now Not?
Thats a partial explanation. Keeping your calories at such a unhealthy level, especially with your activity level, is going to have some reproductions. Your body thinks you are dying. It makes sense your hunger increased. You kinda did it to yourself. The biological need for survival is going to override the meds at some point.

Get back to a healthy deficit, based on where you are now 500-700 calories under maintenance, and you will start to see progress. A stall since December does say that you have not run a deficit in a while so you should be in a place to get back on track. You can continue to try and get meds in balance to help with hunger but an appropriate deficit and a focus on protien and low calorie density food will help.
 
you have been on a very large calorie deficit, so now your body is doing everything it can to have food back into you. Have you considered cagrisema? It should have a really good appetite suppression. Another way I see it is go back to 15mg Tirz and slowly add Reta.
 
Oof. For those of us that were/are pretty big people these drugs losing thier potency is a big time nightmare.

Especially if they seem to quit working before goal. Id split dose every 3.5 days tirz and reta, as well as up my dose if I were you.

Hopefully things like elora will continue to funnel down the pipeline giving those hope for new paths to losing weight and keeping it off for thise of us building tomerances.
 
I startet Tirz this day 2 years ago. I lost around 120 lbs on it and I´m very happy. Was 1 year on 15mg (original stuff from the pharmacy) and on a stall since Dec 2025. I´m not a weight lifting person, I´m a swimmer and do 6 days a week 2 or 3 KM. I want to loose 60 more pounds to get to a normal weight range. I still have 48 % body fat. I started Reta 8 weeks ago and titrated Tirz down. I´m on 7.5 mg Tirz now and on 4mg Reta. But nothing happened so far. Cravings as crazy in the evening looking for snacks and into the fridge... saturday I added 0.25mg Cagri to get some suppression, but I don´t feel anything (like I felt in the beginning with Tirz).
Now I´m thinking, if Eloralintide is a better choice? Or Madzdutide? To get back on track and hit my calorie goal.
I'm coming up on 2 years since I started. I stacked Reta for weight loss and Tirz for appetite suppression. While my weight has been stable in maintenance, I'm definitely finding that the appetite suppression has lessened, and this worries me. I am going to shift from Tirz for appetite suppression to Eloralintide and give that a try in combination with Reta.

On a side note, I was wondering why EL released the rodent studies when they have active human studies on Tirz/Elora pending. I'm guessing it is because they are seeing good results in the human studies but they are too preliminary to release. Maybe they wanted to send a message with the rodent studies that the Tirz/Elora combination really works. Elora is effective on its own equal to Tirz, and with lower side effects. In combination with Tirz the effect is additive. When added to Tirz after a plateau, it breaks the stall and continues the weight loss. Pretty amazing, actually.

I'm in maintenance, which is not what they are studying. But, I'm willing to experiment. I admit that I am terrified of regaining the 112lbs that I lost. I'm willing to take some chances with Eloralintide, even though the results are still early. I won't go back to where I was. I just wont.
 
It sounds like its time to focus more on calories and less on meds. You have been stalled for months which means you have not been eating at a deficit. Logging calories and loading up on less calorie dense food makes more sense than just trying to add more meds. They are best used to help you move to eating a healthier diet rather than as the primary way to lose weight.

You are very active which is awesome and something a lot of people struggle with. You likely feel that your diet has been good but the lenght of your stall means that you are definitely still consuming too many calories. I would highly recommend a calorie tracking app and rigorous logging; really look at what you are putting in and don't just use their suggestions, they have been shown to be wildly off.

I understand looking for that appetite suppression and hopefully you can get that back but in the meantime, I would suggest really looking for less calorie dense foods and focusing on protien and overall volume. That should help some.
I would actually argue that this advice is not the correct advice in this context, someone with severe long term obesity struggling to lose weight on a very low calorie input. Who has stalled 2/3rds of the way to their goal on maximum dose tirz. Is it possible the calorie count of 1300 is inaccurate, yes people are in general very bad at calorie counting, but attempting to use conscious cognitive constraint of calorie input long term as a means to control obesity just does not really work, it can produce short term results, but much less so long term ones. Altering food types eaten is less of a bad idea, I like low calorific density high protein approaches, as it is easier to eat enough food to be less hungry while not consuming too many calories.

The only treatment besides surgery that seems to be able to make a substantial difference in severe obesity so far are GLP drugs. There is not a lot of research on what to do if stalled on maximum doses yet, but there will be eventually, and quite a few people on this forum have had much better than clinical trial results with combinations and higher doses. I find that they help me maintain my weight loss of 55% , but it is taking a tirz/reta/cagri combination to do it.

I am extremely skeptical of advice to increase calorie intake to increase weight loss in this context. This is just not really how bodies work. I do realise there are a few people online who have had success with this approach, but for me in a somewhat similar situation to the OP, of chronic adaptation to low calorie input and weight stable at 1600-1800 kcal/day, even 100kcal/day extra will increase weight.

If the degree of hunger is distressing , one option is to ramp up doses of reta faster, but doing this increases chances of more severe, more sudden side effects. The safest way to do it is split dosing so every 2 to 3 days or twice a week, so that if twice a week , you could go up 0.5mg of reta per dose so 2.5 twice a week then 3mg twice a week etc, so long as you slow down the increases if side effects or appetite suppression starts. But you need to look at glp plotter first. at least with smaller more frequent doses, usually it will only take half as long for side effects to settle down if you start getting them.

If you get to higher doses of reta and are still having major problems, you might be better off going back to tirz, with cagri added, or even some version of reta plus tirz, which seems to work for me. Or even just bump the tirz dose back up to 15 mg with the lower dose reta added on, and low dose cagri, which is essentially exactly what I am taking. I think this degree of polypharmacy with GLP's requires at least some monitoring , ideally medically, but checking blood pressure, lipids, liver function, renal function, blood counts and blood sugars at least is a good idea. And if diabetic especially if on other meds , very careful blood sugar watching.

One other thing is that sometimes people do experience increased hunger on starting reta, due to the glucagon agonism, which settles down after a while as the body adapts to it.
 
Thank you lessthanhalf! Helps me a lot what you wrote!
I have bloodwork done every 3 months with all the necessary values, because I have rheumatism. But this changed a lot in the good direction, since I started Tirz 2 years ago and at the moment I´m inflammation and painfree first time since 12 years. My doctor is very happy about this!
I also have hashimoto, that´s why there was always a struggle to loose weight and Tirz helped me so much to start loosing weight first time since the last 40 years of my obesity history.
I will titrate Reta slowly up and keep a 5 mg dose of Tirz for inflammation control I guess. Must be patient with Reta I guess. Perhaps 4 mg is still not enough for me to start loosing again. But I will also see if splitting doses will be help me controlling hunger.
 
You were on brand name Mounjaro for the first year, then switched to generic tirz of some sort and continued to have success for another six months, then not.

Did you change source, kit batch, etc at around that time? Are you using a kit from a batch that's been third-party tested (not a CoA provided by or via a vendor)? And who is the vendor?
 
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You were on brand name Monjouro for the first year, then switched to generic tirz of some sort and continued to have success for another six months, then not.

Did you change source, kit batch, etc at around that time? Are you using a kit from a batch that's been third-party tested (not a CoA provided by or via a vendor)? And who is the vendor?
No, I´m still on the brand name never switched to grey Tirz. I only have grey Reta. and Cagri.
But the brand Tirz pens are from November, due till 2/27 I don´t know if this is an issue.

I was thinking about recon some T30 from grey to test if it will feel different/stronger
 

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