Heatwave in Europe. Doctor's suggest users of tirzepatide to skip doses to avoid kidney failure because of dehydration.

I do not remember hearing anything ever about GLP drugs causing kidney problems except in one very specific situation, otherwise they slow the progression of renal failure and can improve renal function and reduce protein excretion.

If you have that exact problem where they can cause renal failure, then the advice is always going to be to stop it, as the only issue is dehydration due to uncontrolled vomiting or diarrhoea as a side effect or from overdoses where the dehydration can then cause acute kidney failure.

So on the whole not solid medical advice.
 
Umm, what? Most im aware of is people may naturally drink less fluids due to appetite suppression or nausea. But if conscious about fluid intake, dont see the worry.

Extreme possibility I'm overlooking some symptom people experience, but Im an arguable endurance athlete and have never had a problem with long mountain bike rides or rucks in heat.
 
lessthanhalf said:
I do not remember hearing anything ever about GLP drugs causing kidney problems except in one very specific situation, otherwise they slow the progression of renal failure and can improve renal function and reduce protein excretion.

If you have that exact problem where they can cause renal failure, then the advice is always going to be to stop it, as the only issue is dehydration due to uncontrolled vomiting or diarrhoea as a side effect or from overdoses where the dehydration can then cause acute kidney failure.

So on the whole not solid medical advice.
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That's what I thought. Fake news! Go out on TV and scare people to skip doses instead of drinking more water is the dumbest thing I've heard in a while
 
GLPs can reduce fluid intake, and is being trialed as a treatment for people drinking excessive amounts of water - primary or psychogenic polydipsia. It worked for me dropping fluid intake from 8 litres a day to 4. But under normal circumstances there are a lot of systems regulating thirst and it is not a strong enough effect to override those systems and actually cause problems from low fluid intake. If it caused widespread dehydration it would not improve renal function, and it does.
 
gusterbuster said:
Umm, what? Most im aware of is people may naturally drink less fluids due to appetite suppression or nausea. But if conscious about fluid intake, dont see the worry.

Extreme possibility I'm overlooking some symptom people experience, but Im an arguable endurance athlete and have never had a problem with long mountain bike rides or rucks in heat.
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lessthanhalf said:
GLPs can reduce fluid intake, and is being trialed as a treatment for people drinking excessive amounts of water - primary or psychogenic polydipsia. It worked for me dropping fluid intake from 8 litres a day to 4. But under normal circumstances there are a lot of systems regulating thirst and it is not a strong enough effect to override those systems and actually cause problems from low fluid intake. If it caused widespread dehydration it would not improve renal function, and it does.
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They also mentioned other drugs like ibuprofen not once saying anything about hydration. I know for myself I need to set a timer to remember to drink water because as you said I'm not thirsty as much on tirzepatide. Getting up to pee like 4 times a night is not ideal but you learn to do it half asleep after a while.
 
Its a special type of arrogance that has doctors telling patients that they need to drink enough water. How do they think people made it to adulthood without knowing they need to drink water?!
 
BrightCandle said:
Its a special type of arrogance that has doctors telling patients that they need to drink enough water. How do they think people made it to adulthood without knowing they need to drink water?!
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ZetsuM said:
Why do people act like drinking water is hard.
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It's not the fact that you need to drink water that's the problem it's that you don't drink enough of it when you don't feel thirst. I need a system so I get enough hydration because of it. Always carrying a water bottle where ever I go. My body hides the fact that it's thirsty because of Tirz. In the beginning I got pretty dehydrated because up to that for 40+ years of my life I have drank water when I get thirsty. That's it. Now I don't get thirsty so I don't drink. Got side effects like itching legs and fatigue. My doctor never said anything about this at all. All I heard was less appetite and thoughts about food. Not a word about water. Now I drink and piss like a race horse.
 
JohannesSweden77 said:
It's not the fact that you need to drink water that's the problem it's that you don't drink enough of it when you don't feel thirst. I need a system so I get enough hydration because of it. Always carrying a water bottle where ever I go. My body hides the fact that it's thirsty because of Tirz. In the beginning I got pretty dehydrated because up to that for 40+ years of my life I have drank water when I get thirsty. That's it. Now I don't get thirsty so I don't drink. Got side effects like itching legs and fatigue. My doctor never said anything about this at all. All I heard was less appetite and thoughts about food. Not a word about water. Now I drink and piss like a race horse.
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I can easily drink 2l of water a day even if i'm not thirsty or with normal weather conditions. It's not like water is filling or has a specific taste, wherever i go i order water instead of softdrinks ect. I'm also on Reta, but a pretty low dose (1.5mg). Dropped 4.5 kg now and i'm still drinking 2l a day. And if you can't remember to drink, plenty of apps to help that. I log my water intake in my Garmin app.
 
ZetsuM said:
I can easily drink 2l of water a day even if i'm not thirsty or with normal weather conditions. It's not like water is filling or has a specific taste, wherever i go i order water instead of softdrinks ect. I'm also on Reta, but a pretty low dose (1.5mg). Dropped 4.5 kg now and i'm still drinking 2l a day. And if you can't remember to drink, plenty of apps to help that. I log my water intake in my Garmin app.
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That's amazing. Congrats! Yes now I have it under control with reminders and my beloved water bottle I carry around like a water Gollum. My Preciousssssss!!!
 
Yawn, I live in the deep south, we KNOW how to hydrate in hot weather, air so thick you can wring it out and drink that! Nah, not skipping any doses.
 
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