Recommended Blood Work/Lab Please

[bluewater]

Hi Everyone,

I am seeking advice on what Blood Work Panels I should be getting to get some objective measures on how my stack is performing.
I have been using the following for about 3 months:

• Retatrutide (currently 5mg weekly)
• MOTS-C (10weeks on / 4 weeks off)
• SS31 (10weeks on / 4 weeks off)

Have lost 16.5kg during that time, seen my blood pressure drop, and no longer tired mid afternoon. So objectively everything is heading in a good direction.
Prior to starting (3months ago) I had a the following Blood Panels done (although this coincided with recovering from a low grade infection) so that may explain why CRP was mildly elevated.

BUT I am keen for advice on what other factors I should be monitoring. For example: how do I know if SS31 / MOTS-C is having any noticeable impact on Mitochondrial function / efficiency.

I also have Stable Angina, so any other factors/tests I should be scheduling? I check in with the Cardiologist once a year and he does not have any concerns, other than get the weight off.

 

[Tbagger]

Checking mitochondrial function on blood tests is very tricky. The major problem is heteroplasmy. It's that mutated mitochondria in any given cell can vary significantly and the impact they have on the cellular function is dependent on what cells we are looking at. The threshold for mitochondrial dysfunction on a the brain is extremely low while muscle tissue has a much higher resilience to mutated or oxidized mitochondria. Because of this heteroplasmy variance, the only way to accurately measure mitochondrial function is through genetic sequencing which can get quite expensive.

 

[eidos]

Checking mitochondrial function on blood tests is very tricky. The major problem is heteroplasmy. It's that mutated mitochondria in any given cell can vary significantly and the impact they have on the cellular function is dependent on what cells we are looking at. The threshold for mitochondrial dysfunction on a the brain is extremely low while muscle tissue has a much higher resilience to mutated or oxidized mitochondria. Because of this heteroplasmy variance, the only way to accurately measure mitochondrial function is through genetic sequencing which can get quite expensive.

That's very interesting. Do you have any references to scientific articles on the subject?