I'm thinking about this more... it seams like quite a few people in group buys do not care about endotoxins. I must have assumed, that filtering removed them.why do some people not care about endotoxins, if filters don't remove them, and they can make you sick?
I'm going to tell you a story; apparently today is one of those days when I tell stories.
After earning her bachelor's degree in biochemistry, a good friend of mine landed an internship at a private lab,a good one, in fact; it's now the world leader in its field.
We met up with some friends, she had been doing her internship for a few weeks by then. She was furious with her internship supervisor. “While showing me around the labs, he said, ‘It’s more or less sterile.’ Either it’s sterile or it’s not! What an incompetent!”
We looked at each other and all burst out laughing. Then we tried to explain to her what I'm about to explain to you.
Sterility and endotoxin levels can be measured starting at a certain threshold, the detection limit below which we can't detect anything. Take a look at the COAs available online; when an endotoxin analysis is included and the result is excellent, you'll see something like <5 units.
Then there's a ceiling beyond which it becomes dangerous or toxic. A good result must fall below that limit. And that limit is never zero; it's not an all-or-nothing scenario. It's not the level that's going to kill you either; there's always some margin.
For endotoxins, this is expressed in terms of hours and kilograms of body weight. Simply because our body has what it takes to eliminate them, provided there aren't too many at once. When there are too many endos, it triggers a lot of other immune system reactions, and it can become serious.
You may see people splitting the dose into two weekly doses. Generally, this isn't because of endotoxins, but it does have one advantage: if there were any present, it would lessen the reactions.
Curiously, Paracelsus's saying still holds true: everything is poison, nothing is without poison; it is the dose that makes the poison.
It all comes down to the probability of contamination. That’s what good manufacturing practices in the factory are for, as well as proper packaging for transport. Finally, there are our aseptic practices when preparing and injecting the peptides.
Pharmaceutical companies and pharmacies have rules and oversight procedures, that we don't have access to, to manage the process.
And when we're alone in the middle of all this, we don't understand anything and we may feel like we have no control. It's legitimate to think that way because that's the reality.
And that's when collective intelligence comes into play. Yes, just like bees and ants.
There is a community that shares information, knowledge, and understandings on these topics (and sometimes a little wisdom, because there are a lot of "old people"* here). It’s important to realize that the number of peptide users on this forum is 10 to 100 times greater than any clinical trials, and that we have information that has never been collected in those studies.
This gives us an overview of what's going on. And above all, there are a few resource person, like Peter Magic, the founder of the Janoshik lab, who sees the test results for every batch on the market (and I think the same batches are tested dozens of times by different customers).
In interviews from previous years, he said that in ten years he had seen only two cases with serious problems. He concluded that there was no point in testing for endotoxins.
A few weeks ago, he changed his policy. Not just for marketing reason, since he has enough work, but because batches with high endotoxin levels and sterility issues have appeared on the market.
He cannot reveal the sources of these products because he has a contract with his clients. But what he implies is that this applies only to certain sources: it is not a proportion of the batches from all sellers, but rather certain (new?) unscrupulous sellers.
So if you follow the reviews of each seller on this forum and the Telegram groups where COAs are shared (no DMs, please), and if you choose a seller located as close to the factory as possible and with a fairly large team, you’ll end up finding your preferred seller (it took me 3 weeks on this forum). Just don't buy at a trailer park or the gym, or from someone who contacts you directly. Good vendors don't have time for that and call you "dear."
If, after this (short) text, you aren't at least a little reassured and still don't know what to do, then grey isn't for you.
"Inside every old person is a young person wondering what happened." Groucho Marx
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