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I can feel it within 8-12 hours.
My first dose I felt within a few hours, definitely less than 6. I usually pin at night if 'noise' was there that day and when I wake up to use the bathroom in the middle of the night, no noise. But I'm not above believing I want it to work so badly I've placebo-ed myself.
 
My first dose I felt within a few hours, definitely less than 6. I usually pin at night if 'noise' was there that day and when I wake up to use the bathroom in the middle of the night, no noise. But I'm not above believing I want it to work so badly I've placebo-ed myself.
It's 48+ hours for me to feel anything (pinning 7.2mg/5-days) and it is usually fatigue on the third day.
 
It's 48+ hours for me to feel anything (pinning 7.2mg/5-days) and it is usually fatigue on the third day.
I wonder if my using sema makes a difference. I'm three months in and tried my first .5 dose and got very sick the same day, then remained sick for days. Today is my first day holding down solid food since Christmas.
 
I wonder if my using sema makes a difference. I'm three months in and tried my first .5 dose and got very sick the same day, then remained sick for days. Today is my first day holding down solid food since Christmas.
I stopped "feeling" anything from tirz after the first few weeks. Never felt anything from Reta. Still losing weight. I could notice subtle behavior differences from the beginning of the week to the end.

I've taken a lot of peps and the only one that gives definitive feels to me is pt141.
 
I stopped "feeling" anything from tirz after the first few weeks. Never felt anything from Reta. Still losing weight. I could notice subtle behavior differences from the beginning of the week to the end.

I've taken a lot of peps and the only one that gives definitive feels to me is pt141.
@chmuse is your sickness mostly in the morning?

(The pt141 comment has me wondering)
 
@chmuse is your sickness mostly in the morning?

(The pt141 comment has me wondering)
I wasn't the one who used the pt141 (yet- it is one of the ones I'll eventually be trying, because sema has nuked my libido.)

If you're going where I think you're going, not a possibility for me. But now the idea is in my head and I have anxiety, so I'm probably going to be unable to sleep until I check because life finds a way 😱
 
I wasn't the one who used the pt141 (yet- it is one of the ones I'll eventually be trying, because sema has nuked my libido.)

If you're going where I think you're going, not a possibility for me. But now the idea is in my head and I have anxiety, so I'm probably going to be unable to sleep until I check because life finds a way 😱
Sucks! Tirz took mine away! I hate it. The last time I tried pt141 it brought it back
 
Sucks! Tirz took mine away! I hate it. The last time I tried pt141 it brought it back
It's definitely on my list of 'eventually' (my poor partner lmao.) I'd want to make sure it's safe with all my medications first, I'm on a lot. But between sema and working 6-7 days a week and 2-4 overtime shifts a week it hasn't been a priority.

Would make for a nice day off if our schedules ever manage to align, but he's a scardy cat and probably wouldn't try it with me.
 
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I stopped "feeling" anything from tirz after the first few weeks.

This has been my experience. I felt the first dose within a few hours, same with the next few doses. But it takes a good 24-36 hours to know the most recent dose is working.
 
I get freezing cold within a few hours, but the appetite differences take a day. I am miserably cold for 2 days and then after that only uncomfortably cold until I do another shot.
 
I get freezing cold within a few hours, but the appetite differences take a day. I am miserably cold for 2 days and then after that only uncomfortably cold until I do another shot.

Okay so question for everyone. I'm a 5 foot 10 35 year old male. Before tirz, i was like 280 and high af blood pressure, hot and sweaty all that shit lol.

I'm 195 now and I'm fucking freezing. Like cold as fuck all the time. Am I just feeling temperature as it actually exists or is the tirz making me cold? Lmao I can't figure it out
 
Okay so question for everyone. I'm a 5 foot 10 35 year old male. Before tirz, i was like 280 and high af blood pressure, hot and sweaty all that shit lol.

I'm 195 now and I'm fucking freezing. Like cold as fuck all the time. Am I just feeling temperature as it actually exists or is the tirz making me cold? Lmao I can't figure it out
It's likely the tirz. the whole class of drug seems to have this effect.

Get a few electric blankets and put them around the house.
 
Okay so question for everyone. I'm a 5 foot 10 35 year old male. Before tirz, i was like 280 and high af blood pressure, hot and sweaty all that shit lol.

I'm 195 now and I'm fucking freezing. Like cold as fuck all the time. Am I just feeling temperature as it actually exists or is the tirz making me cold? Lmao I can't figure it out
It's a pretty commonly reported side effect but it is unknown to me if it is a side effect of the weight loss or the tirz directly. All I can say is you are not alone. I got 4 blankets on my bed now 🥶
 
It's a pretty commonly reported side effect but it is unknown to me if it is a side effect of the weight loss or the tirz directly. All I can say is you are not alone. I got 4 blankets on my bed now 🥶
Team four blankets unite!I have a king we share, and a fleece, a twin comforter, and a sherpa on my side. Lots of fuzzy house sweaters too.
 
It's a pretty commonly reported side effect but it is unknown to me if it is a side effect of the weight loss or the tirz directly. All I can say is you are not alone. I got 4 blankets on my bed now 🥶
I was only 250lbs for a few years. I'm currently back to 200 lbs where I was for a very long time. I was NEVER this cold and its specifically my fingers and toes.
 

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