Will anything ever bring the early magic back?

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clayd

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I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?
 
I honestly wonder if for the long term, cycling totally different weight loss peptides during maintenance, meaning drugs that act on completely different receptors, will be the way to go. Like maybe sema for a while and then survo or something like that - to give one set of receptors a chance to reset.
 
I know exactly what you mean. I am currently @ 10mg and have decent hunger suppression but I can still eat a moderate size meal and feel normal. I guess this is good?

When I first started I had to be careful, if I ate too much after about 20 mins I would feel like I ate a whole Thanksgiving meal. Now I eat, but just eat about half as much as my former fat self. However, if my wife didn't cook dinner every night I feel like I could just skip it and not really feel hungry. This isn't healthy so I guess I am glad she cooks and typically cooks very healthy meals.
 
exploitedworkerbee said:
Also, if you don’t care about your wellness and really just don’t want to feel hungry for 12 hours at a time, you can always take a couple of bronkaid (ephedrine) tablets. Combined with tirz you definitely won’t want to eat.
Click to expand...
isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.
 
exploitedworkerbee said:
Adding cagrilintide did the trick for me, maybe you aren’t being aggressive enough with the dosing. This 250mcg business is for the birds.

But of course that is also fleeting, eventually hopefully you get to your goal and don’t need intense suppression anymore.
Click to expand...
currently on 1mg/1mg of cagrisema but just ran out, going back to straight cag, and ready to rock and roll on the dose. what are you on?
 
raw_oyster_eater said:
isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.
Click to expand...
Re: ephedrine, it’s an upper so elevates your heart rate. I think there is medical consensus that this isn’t great for you if you do it in a sustained manner. It’s only in bronkaid and primatine to the best of my knowledge, I don’t think it’s in everything. You have to sign a form when you buy it, and has to be kept behind the pharmacy counter.

Re: rotating meds, I’ve done it quite a bit. There does seem to be a lot of cross-tolerance, and I get to max dose on the new meds quickly. I’ve concluded that never be like those first shots of Ozempic again no matter what I do.
 
exploitedworkerbee said:
Re: ephedrine, it’s an upper so elevates your heart rate. I think there is medical consensus that this isn’t great for you if you do it in a sustained manner. It’s only in bronkaid and primatine to the best of my knowledge, I don’t think it’s in everything. You have to sign a form when you buy it, and has to be kept behind the pharmacy counter.

Re: rotating meds, I’ve done it quite a bit. There does seem to be a lot of cross-tolerance, and I get to max dose on the new meds quickly. I’ve concluded that never be like those first shots of Ozempic again no matter what I do.
Click to expand...
i already take adderall so adding ephedrine isn't in the cards for me. i have taken it once or twice when i couldn't get the addys though. didn't help much for focus.

eh, sad to hear the magic is probably gone forever. hopefully it remains effective anyway even if i get hungry more often. as i type this i just finished off a small bowl of sloppy joe meat leftovers that would have filled me for hours previously and i don't even feel satisfied this time.

definitely going to 15mg tirz and upping the cag asap
 
clayd said:
i already take adderall so adding ephedrine isn't in the cards for me. i have taken it once or twice when i couldn't get the addys though. didn't help much for focus.

eh, sad to hear the magic is probably gone forever. hopefully it remains effective anyway even if i get hungry more often. as i type this i just finished off a small bowl of sloppy joe meat leftovers that would have filled me for hours previously and i don't even feel satisfied this time.

definitely going to 15mg tirz and upping the cag asap
Click to expand...
I’m pretty much where i need to be weight-wise (a touch of body dysmorphia prevents me from ever being truly good with where I’m at no matter what) and have been enjoying reta/cagri. I get hungry and can enjoy food, but portions just magically end up smaller and I don’t often desire snack between meals. I really feel like I can eat whatever I want, because I do. I am not losing weight quickly, but the trend continues downward.
 
I’m wondering the same thing with my own Tirz/Reta experience. Jay Campbell and Hunter Williams suggest cycling Low Dose Naltrexone (0.5-5mg daily) to re-sensitize various peptide receptors. You can get a 30pack of 50mg Naltrexone ($30) and dissolve them yourself for low dose cycling, which would last at least 6months. Alternatively, I would try coming off GLP1s completely and sub Cagri to see if that helps for a few months.
 
As for weight loss, your message sounds like you aren't stacking Reta? I have never seen actual data, but some people claim the glucagon component burns an extra 300+ calories a day. I have been stacking and it has produced weight loss of 2-3 lbs / week. Everyone is different, I know.

On the appetite suppression side I saw a panel discussion with a doctor (I don't recall the site) who said that after some time, I think she said a year, almost everyone starts feeling less appetite suppression. It has only been 7 months for you, so that seems early, but maybe it is just a normal adjustment by your body. Time for some Cagri or Sema?
 
m100568 said:
As for weight loss, your message sounds like you aren't stacking Reta? I have never seen actual data, but some people claim the glucagon component burns an extra 300+ calories a day. I have been stacking and it has produced weight loss of 2-3 lbs / week. Everyone is different, I know.

On the appetite suppression side I saw a panel discussion with a doctor (I don't recall the site) who said that after some time, I think she said a year, almost everyone starts feeling less appetite suppression. It has only been 7 months for you, so that seems early, but maybe it is just a normal adjustment by your body. Time for some Cagri or Sema?
Click to expand...
already stacking cagrisema and have a little more room on the tirz. we'll see. next week i'll take 15mg and i'll probably be back here posting how great it is.
 
raw_oyster_eater said:
isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.
Click to expand...
I watched a YouTube video when I was first doing a gazillion hours of research that suggested cycling on and off on a 8-12 week cycle to keep receptors fresh, and offered that as an idea to someone who had maxed out with lots to lose still on Reddit. It was like I had posted a video of me stomping on a litter of puppies. Full on name-calling and disregarding the possibility of it as 'bro science'. Anyway. Seems like maybe a decent plan, at this point!
FWIW, he also suggested bumping down to 1mg for the 'off' and 2.5 to 5mg for the 'on' in a maintenance situation if you gain much during the 'off' cycle. I'm going to try it when I get there if it seems like a good idea! I also like the idea of swapping out different varieties.
 
I just upped to 15mg today after 3 months at 12.5 (2 months each titration previously, skipping 5mg all together due to name brand shortage). Was still loosing, but slower and I have 20 more to go. My plan is to max the 15 for about 2-3 months, so hopefully by then, I'll be at goal. Then plan to titrate down from Tirz with a few weeks break, before introducing Reta. I have Cagri on standby if the Reta food noise isn"t something I feel like tolerating. I'm more concerned w/ making sure my sugar, cholesterol numbers stay conducive and the inflammation doesn't return.
 
Sunflower said:
I’m wondering the same thing with my own Tirz/Reta experience. Jay Campbell and Hunter Williams suggest cycling Low Dose Naltrexone (0.5-5mg daily) to re-sensitize various peptide receptors. You can get a 30pack of 50mg Naltrexone ($30) and dissolve them yourself for low dose cycling, which would last at least 6months. Alternatively, I would try coming off GLP1s completely and sub Cagri to see if that helps for a few months.
Click to expand...
I just started a daily nal dose, I wonder if that'll make my sema feel magic again? I'm also on bupropion so I'm basically on sema AND Contrave right now. If I don't start losing faster I'll riot.
 
raw_oyster_eater said:
isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.
Click to expand...
I thought about rotating for maintenance! Not a bad idea and even before maintenance
 
chmuse said:
I just started a daily nal dose, I wonder if that'll make my sema feel magic again? I'm also on bupropion so I'm basically on sema AND Contrave right now. If I don't start losing faster I'll riot.
Click to expand...
I don't normally post source questions but is Naltrexone available from the CN vendors or India pharma or do you need a telehealth script?
 
GimmeABreak said:
I don't normally post source questions but is Naltrexone available from the CN vendors or India pharma or do you need a telehealth script?
Click to expand...
I got a script from my actual psych, it just took months to fill. Turns out they won't fill just 30, I had to get a 90 day supply.

When I was having trouble getting it a bunch of people messaged me to try Indian pharmacies, but I didn't end up trying that.
 
clayd said:
I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?
Click to expand...
I read that if you did a 6week wash out you would be able to re-start at lower doses. I was at 10mg. I washed out for 6 weeks and re started at 5mg.
When I did that, I gained 8# and it took me a month to regain forward progress. 🤷‍♀️. I'm still loosing, just not as rapidly as before I think its not just the drug metabolism, but my whole metabolism had changed. Up to a point t I didn't put any effort into exercise. Ut maybe with this last 15#I might
 
Windingroads06 said:
I read that if you did a 6week wash out you would be able to re-start at lower doses. I was at 10mg. I washed out for 6 weeks and re started at 5mg.
When I did that, I gained 8# and it took me a month to regain forward progress. 🤷‍♀️. I'm still loosing, just not as rapidly as before I think its not just the drug metabolism, but my whole metabolism had changed. Up to a point t I didn't put any effort into exercise. Ut maybe with this last 15#I might
Click to expand...
Whatever you do, make sure that you don't take GLP-1 drugs the way they worked most effectively in the clinical trials.
 
chmuse said:
I just started a daily nal dose, I wonder if that'll make my sema feel magic again? I'm also on bupropion so I'm basically on sema AND Contrave right now. If I don't start losing faster I'll riot.
Click to expand...
What daily dose of Nal? I’m curious the difference in how regular dosed Nal affects receptors vs. LDN!

Anecdotally, I did try regular Nal (50mg) daily when I was also on Wellbutrin about a decade ago for bulimia addiction/ cravings. It didn’t touch the bulimia impulses, but I imagine it is different for alcohol/ smoking/ opioid addiction. Also, if people aren’t purging as a part of their food addiction, I suspect the Nal may help more, as that is half the additive component.

Linking Hunter’s LDN video below!
 
GimmeABreak said:
I don't normally post source questions but is Naltrexone available from the CN vendors or India pharma or do you need a telehealth script?
Click to expand...
Idk, but if you get compounded low-dose naltrexone, it is much more expensive than using a Good RX coupon for the regular dose naltrexone from your GP. I don’t have (or need) a GP or health insurance, so my telehealth psychiatrist was willing to prescribe it after a short discussion. $30 for 6-12 months LDN.
 
chmuse said:
I got a script from my actual psych, it just took months to fill. Turns out they won't fill just 30, I had to get a 90 day supply.

When I was having trouble getting it a bunch of people messaged me to try Indian pharmacies, but I didn't end up trying that.
Click to expand...
That’s crazy, was it the pharmacy or your dock that wouldn’t give you a 30 day supply? I filled a 30 day supply here in TX with a GoodRX coupon for $30. Maybe every state has a different guidelines or different pharmacies do?
 
There are at least 5400 women on Reddit who say you take 2.5mg for over a year, and it continues to work perfectly, and it is dangerous if you titrate up. I think you asked this question in a safe space lol

But yes, I started in Feb 2024 and Tirz does absolutely nothing for me besides give me some hard do doos for three days.
 
keangkong said:
Whatever you do, make sure that you don't take GLP-1 drugs the way they worked most effectively in the clinical trials.
Click to expand...
Those dosing plans are optimized so the lowest common denominator doesn’t screw it up. I’m not convinced that weekly dosing is ideal for every single one of these compounds, or that the doses are as one-size-fits-all as was used in the trials.

That said, you’re not wrong. But tweaking for individual variation isn’t totally bonkers
 
Sunflower said:
What daily dose of Nal? I’m curious the difference in how regular dosed Nal affects receptors vs. LDN!

Anecdotally, I did try regular Nal (50mg) daily when I was also on Wellbutrin about a decade ago for bulimia addiction/ cravings. It didn’t touch the bulimia impulses, but I imagine it is different for alcohol/ smoking/ opioid addiction. Also, if people aren’t purging as a part of their food addiction, I suspect the Nal may help more, as that is half the additive component.

Linking Hunter’s LDN video below!
Click to expand...
50mg. We'll see. The Wellbutrin was supposed to be for nicotine which didn't work but it turned out it did wonders for my mood when used with buspirone. The sema helped with the nicotine, I'm using almost none now it's mostly habit. I only just started it so I have no opinion on the nal yet, so far sema worked for alcohol by like 90%.
Sunflower said:
That’s crazy, was it the pharmacy or your dock that wouldn’t give you a 30 day supply? I filled a 30 day supply here in TX with a GoodRX coupon for $30. Maybe every state has a different guidelines or different pharmacies do?
Click to expand...
I honestly don't know, my pharmacy just kept not filling it for like five months then when my psych sent in a 90 day script instead now that she considers me Stable and Trustworthy (tm) all of a sudden they had it. I probably should have asked why, I would have happily just paid for it cash, I had to do that last year when my insurance wouldn't cover lamotrigine in anything less than 90 day supply.
 
I'm at a good weight to be goal weight now. I have noticed the same for the past maybe two months. I am starting to crave sugar like before. I get hungry and start thinking about food out of nowhere. I am eating more, more often but it seems like I still get full where before I never did.

I weigh myself every morning and there have been a few mornings where I just knew I blew it. I am maintaining my weight within 5 pounds. small fluctuations. I suppose if it continues like this and the hunger never comes like before the medicine this is actually ideal and a good place for me to learn and eat slower, with purpose, not skip meals so it comes on full force.

just my current experience

First pin April 2, 2024
sw:220
cw:157-161
 
clayd said:
i already take adderall so adding ephedrine isn't in the cards for me. i have taken it once or twice when i couldn't get the addys though. didn't help much for focus.

eh, sad to hear the magic is probably gone forever. hopefully it remains effective anyway even if i get hungry more often. as i type this i just finished off a small bowl of sloppy joe meat leftovers that would have filled me for hours previously and i don't even feel satisfied this time.

definitely going to 15mg tirz and upping the cag asap
Click to expand...
You take Adderall and you're still hungry? Crazy.
 
exploitedworkerbee said:
Also, if you don’t care about your wellness and really just don’t want to feel hungry for 12 hours at a time, you can always take a couple of bronkaid (ephedrine) tablets. Combined with tirz you definitely won’t want to eat.
Click to expand...
Thanks for the reminder. I think I still have some of them stashed. I remember having to show my license for that purchase as they keep those behind the counter now.
 
My NP said I was in a tough spot when I complained that on the 5th-ish day I wanted to eat everything. She said it was just in my head.

Then I read the entire study on tirz and sema.
The half life is 5 days.
 
Windingroads06 said:
I read that if you did a 6week wash out you would be able to re-start at lower doses. I was at 10mg. I washed out for 6 weeks and re started at 5mg.
When I did that, I gained 8# and it took me a month to regain forward progress. 🤷‍♀️. I'm still loosing, just not as rapidly as before I think its not just the drug metabolism, but my whole metabolism had changed. Up to a point t I didn't put any effort into exercise. Ut maybe with this last 15#I might
Click to expand...
I got to 15mg tirz still had alot to loose ..stopped everything for 6 weeks ..started back at 2.5 then 5 etc... now at 15 again
The way I see it stopping made it go alot longer then if I would had stayed at 15 .. it was a year ago I stopped..
Now at lowest weight ever
 
Windingroads06 said:
My NP said I was in a tough spot when I complained that on the 5th-ish day I wanted to eat everything. She said it was just in my head.

Then I read the entire study on tirz and sema.
The half life is 5 days.
Click to expand...
yep, you'll find lots and lots of folks around these parts that add something else like sema or cag on day 4-5 to get them over the tirz hump, or adjust their tirz dosing to every 5 days.
 
clevesand said:
There are at least 5400 women on Reddit who say you take 2.5mg for over a year, and it continues to work perfectly, and it is dangerous if you titrate up. I think you asked this question in a safe space lol

But yes, I started in Feb 2024 and Tirz does absolutely nothing for me besides give me some hard do doos for three days.
Click to expand...
That is so funny how wildly different our bodies are, bc Tirz, and even moreso Reta now make me poop all day long 🫣 Before Tirz, I could go days without pooping. And I’m only on 2-4mg per week combined.
 
chmuse said:
50mg. We'll see. The Wellbutrin was supposed to be for nicotine which didn't work but it turned out it did wonders for my mood when used with buspirone. The sema helped with the nicotine, I'm using almost none now it's mostly habit. I only just started it so I have no opinion on the nal yet, so far sema worked for alcohol by like 90%.

I honestly don't know, my pharmacy just kept not filling it for like five months then when my psych sent in a 90 day script instead now that she considers me Stable and Trustworthy (tm) all of a sudden they had it. I probably should have asked why, I would have happily just paid for it cash, I had to do that last year when my insurance wouldn't cover lamotrigine in anything less than 90 day supply.
Click to expand...
WTF, like what do they think someone’s gonna do that’s dangerous/ shady with Naltrexone 😭 But yeah, I can empathize with the challenge of having to build “trust” with your psych. I’ve met all kinds of ignorant ones, but my current one is a psychedelic ketamine psychiatrist in Vermont (teleheath) so he’s surprisingly open minded!

Please keep us posted on your Nal experience—I am thankful Tirz fixed the food addiction, but struggling with residual mental “sticky/ disempowering thought” addictions and…Reddit. It seems like you’ve overcome 90+% of the physical dependencies, which is incredible.
 
Sunflower said:
WTF, like what do they think someone’s gonna do that’s dangerous/ shady with Naltrexone 😭 But yeah, I can empathize with the challenge of having to build “trust” with your psych. I’ve met all kinds of ignorant ones, but my current one is a psychedelic ketamine psychiatrist in Vermont (teleheath) so he’s surprisingly open minded!

Please keep us posted on your Nal experience—I am thankful Tirz fixed the food addiction, but struggling with residual mental “sticky/ disempowering thought” addictions and…Reddit. It seems like you’ve overcome 90+% of the physical dependencies, which is incredible.
Click to expand...
I'm bipolar and I started seeing them because I was unmedicated and having a hypomanic episode (looking back, I think I may have been actually manic and just not well enough to see it- just poorly enough to know I wasn't feeling RIGHT) so it makes sense they wanted me seeing them every month until I was stable. Then the first one stopped taking my insurance, and the second one sent me to another new psych when I asked for antabuse because she considered me a seizure risk (I wasn't, to be clear...) then another insurance issue.... 🙃 I've finally been with one long enough to go to every three months for appointments. I saw the same woman for seven years in my early twenties and I despised her, but that continuity of care was nice, looking back. 😅🥲

I'm now on nal, sema, AND cagri. I'm doing pretty damn great, but I can't tell you which of the three to attribute that to. Drinking also stops my weight loss progress, so having a concrete goal and consequences is helping. Drinking = sema no workie = no drinkie for ChMuse. From what I've seen sema seems best for those addictive behaviors (I've actually cut down on Reddit and TikTok by miles, I've read four books so far in January.)
 
chmuse said:
I'm bipolar and I started seeing them because I was unmedicated and having a hypomanic episode (looking back, I think I may have been actually manic and just not well enough to see it- just poorly enough to know I wasn't feeling RIGHT) so it makes sense they wanted me seeing them every month until I was stable. Then the first one stopped taking my insurance, and the second one sent me to another new psych when I asked for antabuse because she considered me a seizure risk (I wasn't, to be clear...) then another insurance issue.... 🙃 I've finally been with one long enough to go to every three months for appointments. I saw the same woman for seven years in my early twenties and I despised her, but that continuity of care was nice, looking back. 😅🥲

I'm now on nal, sema, AND cagri. I'm doing pretty damn great, but I can't tell you which of the three to attribute that to. Drinking also stops my weight loss progress, so having a concrete goal and consequences is helping. Drinking = sema no workie = no drinkie for ChMuse. From what I've seen sema seems best for those addictive behaviors (I've actually cut down on Reddit and TikTok by miles, I've read four books so far in January.)
Click to expand...
Very interesting story thanks for sharing.

Everyone said tirz curbed their drinking and it didn't change mine at all, but since I started in on the cagrisema, I have cut back, now that I think about it. Maybe sema is helping some there. It would be welcome assistance.

Naltrexone never seemed to really help me much but it did make me throw up all the time. Doc said that should subside but it never seemed to.

Glad you are in a better place @chmuse
 
clayd said:
Very interesting story thanks for sharing.

Everyone said tirz curbed their drinking and it didn't change mine at all, but since I started in on the cagrisema, I have cut back, now that I think about it. Maybe sema is helping some there. It would be welcome assistance.

Naltrexone never seemed to really help me much but it did make me throw up all the time. Doc said that should subside but it never seemed to.

Glad you are in a better place @chmuse
Click to expand...
Sorry for derailing 😅 Don't tell Yoyo.

Everything I've seen is that sema hits that receptor hardest and it seems to be the one that's helping with addictive behaviors. I think someone posted a chart saying survo and maz also work similarly? Sema is the one in active research for addiction medication, anyway. There's entire subreddits for it.

A lot of people seem to react to nal that way, which I think is part of why the Sinclair Method works.
 
clayd said:
I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?
Click to expand...
Hi there! I’m fairly new to all of this but just read a very interesting article that explains the plateaus in out weight loss journey and thought maybe it could help you.

Good luck in your journey!

file:///var/mobile/Library/SMS/Attachments/fd/13/2275B90E-AF75-4E8B-AF57-8CBE6187E294/Tirzapatide_The_Missing_Manual_v_0_95_20230901_Compressed_1.pdf
 
chmuse said:
I'm bipolar and I started seeing them because I was unmedicated and having a hypomanic episode (looking back, I think I may have been actually manic and just not well enough to see it- just poorly enough to know I wasn't feeling RIGHT) so it makes sense they wanted me seeing them every month until I was stable. Then the first one stopped taking my insurance, and the second one sent me to another new psych when I asked for antabuse because she considered me a seizure risk (I wasn't, to be clear...) then another insurance issue.... 🙃 I've finally been with one long enough to go to every three months for appointments. I saw the same woman for seven years in my early twenties and I despised her, but that continuity of care was nice, looking back. 😅🥲

I'm now on nal, sema, AND cagri. I'm doing pretty damn great, but I can't tell you which of the three to attribute that to. Drinking also stops my weight loss progress, so having a concrete goal and consequences is helping. Drinking = sema no workie = no drinkie for ChMuse. From what I've seen sema seems best for those addictive behaviors (I've actually cut down on Reddit and TikTok by miles, I've read four books so far in January.)
Click to expand...
Isn’t it exciting the possibilities we are seeing with the GLP1s and mental health?! Do you feel Sema has a stronger impulse control effect than Tirz?

Oh yeah, the challenges with bipolar are compounded when we are on an SSRI/ SNRI/ NDRI and then get mood shifts in mania/ hypo/ depression. It’s can be hard to distinguish what’s an actual bipolar symptom vs. medication exacerbating the mental state. And then there’s digging through (possible) childhood trauma trying to unravel how strongly that’s linked to bipolar. I wish we could all get regular brain scans while we are undergoing treatments 😆
 
Sunflower said:
Isn’t it exciting the possibilities we are seeing with the GLP1s and mental health?! Do you feel Sema has a stronger impulse control effect than Tirz?

Oh yeah, the challenges with bipolar are compounded when we are on an SSRI/ SNRI/ NDRI and then get mood shifts in mania/ hypo/ depression. It’s can be hard to distinguish what’s an actual bipolar symptom vs. medication exacerbating the mental state. And then there’s digging through (possible) childhood trauma trying to unravel how strongly that’s linked to bipolar. I wish we could all get regular brain scans while we are undergoing treatments 😆
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Bipolar has been linked to blood glucose! Increased risk of type 1 and 2 diabetes, and iirc a link was found with 1.5 recently too. 😬 So a glp-1 helping makes a ton of sense to me- especially as keto had mine so well controlled until I couldn't maintain such a strict diet. No opinion on tirz, I haven't tried it yet. Sema had an immediate effect for me- within hours of the first dose, it was like a button in my brain had been pressed. Magic. I've only done sema and one dose of cagri so far (second dose tonight.) And parsing through everything is so incredibly difficult, sooooo many possible and common comorbidities, and environmental factors, etc etc.
 
clayd said:
I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?
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This just isn't healthy. And you will thoroughly regret it by the time you reach your goal weight.
 
Similar experience:
S

Post in thread 'Eating a lot while on 7.5mg/w tirzepatide'

brentm said:
Sprinkle in a little cheap semaglutide on it...

Or increase the Tirz dose...

I think also you'll have some days where the Tirz is effective and some days where you feel like raiding the cookie jar. Is it real hunger or is your brain telling you if you have a snack you'll feel better?

Mostly for me I'm not hungry but I eat anyway.

Couple thoughts.... For your RS. I'd probably stack a little Semaglutide on the regimen. If you do this... don't get fancy with a shot of it every other day.... follow the recommended weekly titration schedule.
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Thanks for the advice.

It's not physical...
 
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