Will anything ever bring the early magic back?

[clayd]

I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?

 

[clayd]

I honestly wonder if for the long term, cycling totally different weight loss peptides during maintenance, meaning drugs that act on completely different receptors, will be the way to go. Like maybe sema for a while and then survo or something like that - to give one set of receptors a chance to reset.

 

[exploitedworkerbee]

Adding cagrilintide did the trick for me, maybe you aren’t being aggressive enough with the dosing. This 250mcg business is for the birds.

But of course that is also fleeting, eventually hopefully you get to your goal and don’t need intense suppression anymore.

 

[penewbie]

The lead researcher for the EL trials says no, but that it doesn't matter, because the weight stays off.

Of course, her trials don't involve stacking with different companies' drugs.

 

[exploitedworkerbee]

Also, if you don’t care about your wellness and really just don’t want to feel hungry for 12 hours at a time, you can always take a couple of bronkaid (ephedrine) tablets. Combined with tirz you definitely won’t want to eat.

 

[GimmeABreak]

I know exactly what you mean. I am currently @ 10mg and have decent hunger suppression but I can still eat a moderate size meal and feel normal. I guess this is good?

When I first started I had to be careful, if I ate too much after about 20 mins I would feel like I ate a whole Thanksgiving meal. Now I eat, but just eat about half as much as my former fat self. However, if my wife didn't cook dinner every night I feel like I could just skip it and not really feel hungry. This isn't healthy so I guess I am glad she cooks and typically cooks very healthy meals.

 

[raw_oyster_eater]

Also, if you don’t care about your wellness and really just don’t want to feel hungry for 12 hours at a time, you can always take a couple of bronkaid (ephedrine) tablets. Combined with tirz you definitely won’t want to eat.

isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.

 

[clayd]

Adding cagrilintide did the trick for me, maybe you aren’t being aggressive enough with the dosing. This 250mcg business is for the birds.

But of course that is also fleeting, eventually hopefully you get to your goal and don’t need intense suppression anymore.

currently on 1mg/1mg of cagrisema but just ran out, going back to straight cag, and ready to rock and roll on the dose. what are you on?

 

[exploitedworkerbee]

isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.

Re: ephedrine, it’s an upper so elevates your heart rate. I think there is medical consensus that this isn’t great for you if you do it in a sustained manner. It’s only in bronkaid and primatine to the best of my knowledge, I don’t think it’s in everything. You have to sign a form when you buy it, and has to be kept behind the pharmacy counter.

Re: rotating meds, I’ve done it quite a bit. There does seem to be a lot of cross-tolerance, and I get to max dose on the new meds quickly. I’ve concluded that never be like those first shots of Ozempic again no matter what I do.

 

[clayd]

Re: ephedrine, it’s an upper so elevates your heart rate. I think there is medical consensus that this isn’t great for you if you do it in a sustained manner. It’s only in bronkaid and primatine to the best of my knowledge, I don’t think it’s in everything. You have to sign a form when you buy it, and has to be kept behind the pharmacy counter.

Re: rotating meds, I’ve done it quite a bit. There does seem to be a lot of cross-tolerance, and I get to max dose on the new meds quickly. I’ve concluded that never be like those first shots of Ozempic again no matter what I do.

i already take adderall so adding ephedrine isn't in the cards for me. i have taken it once or twice when i couldn't get the addys though. didn't help much for focus.

eh, sad to hear the magic is probably gone forever. hopefully it remains effective anyway even if i get hungry more often. as i type this i just finished off a small bowl of sloppy joe meat leftovers that would have filled me for hours previously and i don't even feel satisfied this time.

definitely going to 15mg tirz and upping the cag asap

 

[exploitedworkerbee]

i already take adderall so adding ephedrine isn't in the cards for me. i have taken it once or twice when i couldn't get the addys though. didn't help much for focus.

eh, sad to hear the magic is probably gone forever. hopefully it remains effective anyway even if i get hungry more often. as i type this i just finished off a small bowl of sloppy joe meat leftovers that would have filled me for hours previously and i don't even feel satisfied this time.

definitely going to 15mg tirz and upping the cag asap

I’m pretty much where i need to be weight-wise (a touch of body dysmorphia prevents me from ever being truly good with where I’m at no matter what) and have been enjoying reta/cagri. I get hungry and can enjoy food, but portions just magically end up smaller and I don’t often desire snack between meals. I really feel like I can eat whatever I want, because I do. I am not losing weight quickly, but the trend continues downward.

 

[Sunflower]

I’m wondering the same thing with my own Tirz/Reta experience. Jay Campbell and Hunter Williams suggest cycling Low Dose Naltrexone (0.5-5mg daily) to re-sensitize various peptide receptors. You can get a 30pack of 50mg Naltrexone ($30) and dissolve them yourself for low dose cycling, which would last at least 6months. Alternatively, I would try coming off GLP1s completely and sub Cagri to see if that helps for a few months.

 

[m100568]

As for weight loss, your message sounds like you aren't stacking Reta? I have never seen actual data, but some people claim the glucagon component burns an extra 300+ calories a day. I have been stacking and it has produced weight loss of 2-3 lbs / week. Everyone is different, I know.

On the appetite suppression side I saw a panel discussion with a doctor (I don't recall the site) who said that after some time, I think she said a year, almost everyone starts feeling less appetite suppression. It has only been 7 months for you, so that seems early, but maybe it is just a normal adjustment by your body. Time for some Cagri or Sema?

 

[clayd]

As for weight loss, your message sounds like you aren't stacking Reta? I have never seen actual data, but some people claim the glucagon component burns an extra 300+ calories a day. I have been stacking and it has produced weight loss of 2-3 lbs / week. Everyone is different, I know.

On the appetite suppression side I saw a panel discussion with a doctor (I don't recall the site) who said that after some time, I think she said a year, almost everyone starts feeling less appetite suppression. It has only been 7 months for you, so that seems early, but maybe it is just a normal adjustment by your body. Time for some Cagri or Sema?

already stacking cagrisema and have a little more room on the tirz. we'll see. next week i'll take 15mg and i'll probably be back here posting how great it is.

 

[cldfront]

isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.

I watched a YouTube video when I was first doing a gazillion hours of research that suggested cycling on and off on a 8-12 week cycle to keep receptors fresh, and offered that as an idea to someone who had maxed out with lots to lose still on Reddit. It was like I had posted a video of me stomping on a litter of puppies. Full on name-calling and disregarding the possibility of it as 'bro science'. Anyway. Seems like maybe a decent plan, at this point!
FWIW, he also suggested bumping down to 1mg for the 'off' and 2.5 to 5mg for the 'on' in a maintenance situation if you gain much during the 'off' cycle. I'm going to try it when I get there if it seems like a good idea! I also like the idea of swapping out different varieties.

 

[janedoe]

I just upped to 15mg today after 3 months at 12.5 (2 months each titration previously, skipping 5mg all together due to name brand shortage). Was still loosing, but slower and I have 20 more to go. My plan is to max the 15 for about 2-3 months, so hopefully by then, I'll be at goal. Then plan to titrate down from Tirz with a few weeks break, before introducing Reta. I have Cagri on standby if the Reta food noise isn"t something I feel like tolerating. I'm more concerned w/ making sure my sugar, cholesterol numbers stay conducive and the inflammation doesn't return.

 

[chmuse]

I’m wondering the same thing with my own Tirz/Reta experience. Jay Campbell and Hunter Williams suggest cycling Low Dose Naltrexone (0.5-5mg daily) to re-sensitize various peptide receptors. You can get a 30pack of 50mg Naltrexone ($30) and dissolve them yourself for low dose cycling, which would last at least 6months. Alternatively, I would try coming off GLP1s completely and sub Cagri to see if that helps for a few months.

I just started a daily nal dose, I wonder if that'll make my sema feel magic again? I'm also on bupropion so I'm basically on sema AND Contrave right now. If I don't start losing faster I'll riot.

 

[Nikki nik]

isn't there like a ca-zillion OTC products with that ingredient? don't see a lot of people dropping dead.

there's caffiene tabs, green tea, chromium and a lot of different herbals.

i suggested rotating the major glps every 6 months in a post here a long time ago and got crapped on as always. it allows a reset.

I thought about rotating for maintenance! Not a bad idea and even before maintenance

 

[GimmeABreak]

I just started a daily nal dose, I wonder if that'll make my sema feel magic again? I'm also on bupropion so I'm basically on sema AND Contrave right now. If I don't start losing faster I'll riot.

I don't normally post source questions but is Naltrexone available from the CN vendors or India pharma or do you need a telehealth script?

 

[chmuse]

I don't normally post source questions but is Naltrexone available from the CN vendors or India pharma or do you need a telehealth script?

I got a script from my actual psych, it just took months to fill. Turns out they won't fill just 30, I had to get a 90 day supply.

When I was having trouble getting it a bunch of people messaged me to try Indian pharmacies, but I didn't end up trying that.