every 5 days I take something. on the days of the months with 5 I'll take tirz (5th, 15th, 25th) and on the 10th days I'll take sema (10th, 20th, 30th) that's how I remember to take them. I've been taking both for awhile. I started on sema 3 years ago and then when tirz came out a I got a script for it.
Want to stack sema......
- Thread starter Iamnew2this
- Start date
every 5 days I take something. on the days of the months with 5 I'll take tirz (5th, 15th, 25th) and on the 10th days I'll take sema (10th, 20th, 30th) that's how I remember to take them. I've been taking both for awhile. I started on sema 3 years ago and then when tirz came out a I got a script for it.
Iamnew2this
GLP-1 Specialist
I like that idea. It's very interesting. Did you start that combo on lower doses of tirz, other than 15mg?
I did two changes in the last 15 days:
- Increased tirzepatide from 8.5 to 10 (Wednesday shot)
- Added 0.25 semaglutide on Saturday
I had some queasiness after my first sema dose, not really nausea, and the fullness feeling and food aversion definitely returned. Food noise is very controlled, hunger decreased considerably.
My first dose of sema pushed my RHR by 4 bpm but it decreased a few days later.
Seems like the perfect mix for me at this point.
What a great feeling that must be — happy for you!
(ps. A big ol' scoop of Tirz with some Sema sprinkles on top has been the "perfect mix" for me for a long, long time. And before anyone asks, I no longer follow any protocol ... I just follow my body's signals.)
Iamnew2this
GLP-1 Specialist
That's great! I like the full feeling the sema gives off. I wasn't losing taking just the tirz or when I decided to incorporate the two. I increased my tirz dose to 12.5mg. I think that it might be working. That's not to say that I will never stack the two. I think that they compliment each other. I'm at 12.5 and it seems to be working. I will take this as long as it works. When that stops, I'll use sema sprinkles and see how that goes.(I'm going to ask Garbo next, lol).If I have to go up to 15mg, then I'll do it. I will see how my body responds and go that route. I'm happy that you found the perfect combination! 👍
Iamnew2this
GLP-1 Specialist
Ok, now I'm coming to ask you, lol. When did you start adding sema to your tirz? I hope that you don't mind me asking. I like the feel of the both of them together. I just think that I had to increase my tirz dose. I'm at 12.5mg now, and getting up there, and will probably use the both of them at some point.
Iamnew2this
GLP-1 Specialist
I find that sema does help better with food noise and helps making me fell fuller faster and longer when added with tirz. They are almost the same and yes tirz has some extra benefits. When tirz stops working as well as it should, I think a little sema is a great choice to add, in my opinion.
Calm Logic
GLP-1 Specialist
But how do you compare that to just taking an additional 2.5 mg of tirz? The reason I ask is because I would be willing to eventually go up to 20 mg of tirz (or maybe even more).
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Iamnew2this
GLP-1 Specialist
That's true, as well. Some people don't mind going up taking higher doses of tirz. It just depends on what works best for an individual during their journey and even during maintenance. Adding sema is a personal choice. In the end, it's all trial and error. I find that I like adding sema to tirz.
You make a great point. I did both: I increased tirz (8.5 to 10 - weekly dose) and also added sema 0.25 4 days later.
Sema is very strong on the GLP-1 component - and anecdotally - better at hunger management food noise suppression.
Before adding sema, my tirz wasn't enough to control the desperate hunger, that one that is still present even after eating a decent size portion. I didn't have any fullness feeling and had constant food noise. I didn't even feel it in the first few days after my shot so I clearly needed to go up.
So I tried increasing tirz and adding a sparkle of more glp-1 to see how it would work, based on other people experiences. It worked really good and that "hunger desperation" went away.
Ultimately, maybe 10 tirz + 0.25 sema is equal to 12.5 tirz? And my jump was the equivalent of 8.5 to 12.5 tirz and that's why I'm seeing the difference. No one truly knows. I'm not scared of going up in tirz, in fact, I'll probably will increase tirz to 12.5 first if I see the issue, and then jump on sema 0.5, etc. As I'm getting closer to GW, my body is probably pushing back heavily.
I'm ok to go over 15mg of tirz, and/or add more sema on top - in fact both have higher trials going on. Sema going to 7.2 and tirz unknown amounts but supposedly 20-25-30 range.
Iamnew2this
GLP-1 Specialist
I totally agree 👍 Those last pounds can become frustrating. They will eventually come off. You're doing the #1 thing for your body that only you would know. You're listening to it and treating it accordingly. Only you would know that. This is why it's such a personal preference.
Someone had posted a cool graphic, I cannot find it now.
It basically shows the strengths of each GLP-1, GIP, and Glucagon.
It seems the crux of the argument involves sema's ability to provide satiety.
Retatrutide, tirzepatide, and semaglutide are all glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications that help with weight loss and blood sugar control. Retatrutide is a triple agonist, targeting GLP-1, GIP, and GCG receptors, while tirzepatide is a dual agonist targeting GLP-1 and GIP receptors, and semaglutide is a single agonist targeting GLP-1. Retatrutide is generally considered to be more effective for weight loss than tirzepatide and semaglutide, with early trials showing up to 24.2% weight loss.
here is a graphic i did find, though the other has scoring system.
It basically shows the strengths of each GLP-1, GIP, and Glucagon.
It seems the crux of the argument involves sema's ability to provide satiety.
Retatrutide, tirzepatide, and semaglutide are all glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications that help with weight loss and blood sugar control. Retatrutide is a triple agonist, targeting GLP-1, GIP, and GCG receptors, while tirzepatide is a dual agonist targeting GLP-1 and GIP receptors, and semaglutide is a single agonist targeting GLP-1. Retatrutide is generally considered to be more effective for weight loss than tirzepatide and semaglutide, with early trials showing up to 24.2% weight loss.
here is a graphic i did find, though the other has scoring system.
Iamnew2this
GLP-1 Specialist
I like the idea about taking reta. I would love to try it. I don't think that it would be a good option for me because, I have heart issues. In my case, I go with what I know. It's all a matter of personal preference. But, yes, reta sounds like a great med. 👍
Hey there, youarenew2this.
Welp, if I'd answered your question spontaneously, I would've said I waited until taking higher doses of Tirz to add Sema.
But it turns out, I would've been accidentally lying, oops.
Your question got me wondering, so I (finally) checked my records — and it seems I began adding Sema less than 2 months after starting Tirz, when still at low doses. Wut?! I was surprised to discover this!
ps. I've read thru some of your posts here, and find we think/feel/choose very similarly. So naturally, I think you're great and you're doing just fine 😉😂
Iamnew2this
GLP-1 Specialist
Thank you, so much! I feel so much better just knowing this since, Iamnew2this. I've been on tirz since September. I actually started with Mounjaro from my doctor. My insurance didn't cover it. In October, I started compound. It was great and still a bit expensive. I finally took the plunge with these peptides and I'm happy where I am now. I like having the autonomy to listen to my body and take care of it from there, and like the price. I'm very happy that I found this forum. I feel more confident now. Great minds think alike.😂 Thanks for getting back👍
