Stacking peptides with SS-31

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Amuse84

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I think I’m going to start ss31. I purchased some MotsC but didn’t feel much. Watched this guys video - https://www.tiktok.com/t/ZP86fEfs4/

- plus read posts on here and Reddit so was going to stop the Mots and order some ss31.

I’m currently switching off Sema (been on it for about 7 months through a compounding pharmacy, lost 40 lbs) to Reta and added Cagri. Been so damn tired. I also work nights though plus really struggle with eating enough. Besides a lack of calories, my diet is AMAZING. Like never before. I’ve struggled terribly with a binge eating disorder most of my life. Currently eating salads every day, fruit, veggies, learn meat. When I snack I eat healthy. I have maybe a cheat meal a week when I go out with friends, but am even getting better with choosing healthier options when out. It’s just so easy to choose healthy. Yet, I’m still not able to consume enough. Still have super low energy (this started with the cagri about 2 weeks ago) I’ve had to cut back on my workouts because I know it’s not good to workout without calories plus I’m beyond tired lately. My calorie intake recently has ranged from 900 to 1500. On a good day I’ll get 100g of protein but on back day maybe 40g. It’s hard to manage all of this, was even thinking about doing a coaching session for maybe some help.

Would love to read any updates or experience from others. What has helped you eat enough or snacks? Whats worked or not working. how do you manage figuring all of this out and staying on track
 
Amuse84 said:
I think I’m going to start ss31. I purchased some MotsC but didn’t feel much. Watched this guys video - https://www.tiktok.com/t/ZP86fEfs4/

- plus read posts on here and Reddit so was going to stop the Mots and order some ss31.

I’m currently switching off Sema (been on it for about 7 months through a compounding pharmacy, lost 40 lbs) to Reta and added Cagri. Been so damn tired. I also work nights though plus really struggle with eating enough. Besides a lack of calories, my diet is AMAZING. Like never before. I’ve struggled terribly with a binge eating disorder most of my life. Currently eating salads every day, fruit, veggies, learn meat. When I snack I eat healthy. I have maybe a cheat meal a week when I go out with friends, but am even getting better with choosing healthier options when out. It’s just so easy to choose healthy. Yet, I’m still not able to consume enough. Still have super low energy (this started with the cagri about 2 weeks ago) I’ve had to cut back on my workouts because I know it’s not good to workout without calories plus I’m beyond tired lately. My calorie intake recently has ranged from 900 to 1500. On a good day I’ll get 100g of protein but on back day maybe 40g. It’s hard to manage all of this, was even thinking about doing a coaching session for maybe some help.

Would love to read any updates or experience from others. What has helped you eat enough or snacks? Whats worked or not working. how do you manage figuring all of this out and staying on track
Click to expand...
Your story seems similar to mine..
A few things that worked for me:
Diet- Lots of protein, chicken breast, yogurt, shakes, bars 120+ daily at 1200 calories
Lots of fluids/electrolytes: liquid IV, black coffee, lots of water bottles

Other stacks, SS-31, Lipo-c w/b12, Mots-C, Nad+
adding TMG and Coq10 supplement

Has helped w/ fatigue, and consistent loss
 
Just drop the cagri. You're having negative side effects and should be simplifying things not complicating them.
 
Why are you choosing to stop the sema?

Cagri makes a lot of people tired. Drop it and just increase the reta. If you're not consuming enough, why add cagri? Reta does it's magic even while you eat.

Try to focus on protein. I know I get full fast so I eat the protein portion of my meal first, then move on to the veggies/grains/whatever.

I'm currently experimenting with ss31.... I'm yolo-ing it a little and following the first protocol I saw multiple people saying they like. Do your research, do you even need it? Or are you just doing it because all the cool kids are? (That's not an insult- just something to think about.)
 
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No need to chime in about cagri. Those are good answers above.

The SS-31 gave me a feeling that something was actually "working" on me. It's a good feeling. I ran 5mg for 5 days on, 2 days off for 5 weeks (100mg) followed by the Mots-c protocol I'm on now. Mots-c is 6mg mon and wed, 8mg fri (20mg weekly) for 5 weeks.

Mots-c has given me more get up go motivation, but I feel like the SS-31 prepared my engine to run high power fuel. Otherwise, I'm not sure I'd get as good an effect.
 
Skidude said:
Your story seems similar to mine..
A few things that worked for me:
Diet- Lots of protein, chicken breast, yogurt, shakes, bars 120+ daily at 1200 calories
Lots of fluids/electrolytes: liquid IV, black coffee, lots of water bottles

Other stacks, SS-31, Lipo-c w/b12, Mots-C, Nad+
adding TMG and Coq10 supplement

Has helped w/ fatigue, and consistent loss
Click to expand...
Just started SS-31(3rd day) and I am so dang tired! Only currently on NAD and methylene blue. So you think the TMG and Coq10 helped you with that?
 
It is challenging to pin point the advantages of these for energy, the entire stack was initiated to help support the process of various peps as I read that the SS-31 would basically optimize the MOTS in the eventual addition to it after 4 weeks on ss-31. I will say ensuring that I had adequate proteins and fluids was likely the most positive influence on the feels. Most of the discussions I have seen surrounding fatigue were either diet based or stronger peps/etc to create energy.
The effects of this stack were subtle in the way they "felt".

The protocol i followed was basically:

1747267585544.png



Taking TMG (trimethylglycine) alongside NAD+ supplements like NMN (nicotinamide mononucleotide) can help maintain healthy methylation levels, which are essential for various bodily functions. TMG acts as a methyl donor, replenishing methyl groups that can be depleted by NAD+ precursors. This can ensure optimal cellular energy production, anti-aging processes, and other benefits associated with NAD+ supplementation.


Here's a more detailed explanation:
  • Methylation and its Importance:
    Methylation is a crucial process involving the transfer of methyl groups, which are a methyl group consisting of a carbon atom bonded to three hydrogen atoms, to other molecules. It plays a role in DNA repair, neurotransmission, and other vital functions.

  • NAD+ and Methylation:
    NAD+ (nicotinamide adenine dinucleotide) is a key molecule involved in energy metabolism and cellular processes. When NAD+ precursors like NMN are taken, they can increase NAD+ levels, which also increases the production of methylnicotinamide (MeNAM).

  • TMG's Role:
    TMG provides methyl groups that can be used in these processes, including the conversion of NAD+ to MeNAM. If the body doesn't have enough methyl groups, it can compromise methylation processes, potentially diminishing the benefits of NAD+ supplements or causing other health issues.

  • Why TMG with NAD+?
    By supplementing with TMG alongside NMN, individuals can ensure they have adequate methyl groups to support methylation processes, potentially enhancing the benefits of NAD+ supplementation and promoting overall health.

  • David Sinclair's Approach:
    Dr. David Sinclair, a prominent researcher in aging, takes TMG as a precautionary measure when supplementing with NMN.

  • Potential Benefits:
    The combination of TMG and NAD+ supplements may support cardiovascular health, boost athletic performance, and regulate insulin levels.
 
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Tilted Halo said:
Just started SS-31(3rd day) and I am so dang tired! Only currently on NAD and methylene blue. So you think the TMG and Coq10 helped you with that?
Click to expand...
And on the CoQ10

Coenzyme Q10 (CoQ10) can enhance the effects of other supplements, particularly those related to heart health, exercise, and overall well-being. It works by boosting energy production, reducing oxidative stress, and improving nutrient absorption, thus supporting the function of other supplements.
Here's how CoQ10 can synergize with other supplements:
Coenzyme Q10 (CoQ10) and SS-31 are both associated with mitochondrial health and function, but they work in different ways. CoQ10 is a natural antioxidant that plays a key role in the electron transport chain, while SS-31 is a mitochondria-targeted peptide that reduces oxidative stress and improves mitochondrial function.

Coenzyme Q10 (CoQ10):
  • Role:
    CoQ10 is a crucial component of the electron transport chain within mitochondria, which is responsible for generating energy (ATP).

  • Function:
    It acts as an antioxidant, helping to protect cells from damage caused by free radicals.

  • Potential benefits:
    Supplementation with CoQ10 has been linked to various benefits, including improved cardiovascular health and increased energy levels.
In summary:
  • CoQ10 is a natural antioxidant involved in the electron transport chain, while SS-31 is a mitochondria-targeted peptide with antioxidant and mitochondrial protective effects.

  • Both CoQ10 and SS-31 have potential benefits for mitochondrial health and function, but they work through different mechanisms.

  • SS-31 has shown promise in animal models of various diseases, while CoQ10 supplementation is linked to benefits like improved cardiovascular health and increased energy levels.
 
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Tilted Halo said:
Just started SS-31(3rd day) and I am so dang tired! Only currently on NAD and methylene blue. So you think the TMG and Coq10 helped you with that?
Click to expand...
I have only seen one issue with the methylene blue, and that was with Tesofensine. As Teso was part of my stack I did not research it further. However there does not immediately appear to be an issue with mixing it with this stack as long as you are not taking any SSRIs. I cannot speak towards this in any detail as I am not aware and have not read in detail. Here is what I read about Teso and Methylene blue:

The combination of methylene blue and tesofensine is not specifically addressed in the provided search results. However, the information available regarding methylene blue and other serotonergic drugs raises concerns about potential interactions.
Understanding the Potential Risks
  • Methylene Blue and Serotonin Syndrome: Methylene blue is a monoamine oxidase inhibitor (MAOI), particularly affecting MAO-A. This means it can increase serotonin levels in the brain.
  • Serotonergic Drugs and Serotonin Syndrome: Many antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), increase serotonin levels. Combining them with MAOIs like methylene blue can lead to a dangerous condition called serotonin syndrome.
  • Tesofensine's Mechanism: Tesofensine is a triple monoamine reuptake inhibitor (serotonin, norepinephrine, and dopamine). It's primarily studied for potential use in obesity treatment.
Why This Combination Could Be Risky:
Since tesofensine increases serotonin levels, combining it with methylene blue, which also increases serotonin levels by inhibiting its breakdown, could potentially lead to excessive serotonin accumulation in the brain. This could result in serotonin syndrome, a potentially life-threatening condition.
Serotonin Syndrome Symptoms:
Serotonin syndrome can cause a range of symptoms, including:
  • Mental changes (confusion, agitation)
  • Muscle problems (twitching, rigidity)
  • Autonomic nervous system issues (fever, sweating, increased heart rate)
Important Note:
The Food and Drug Administration (FDA) has issued warnings about combining methylene blue with serotonergic psychiatric medications due to the risk of serotonin syndrome. While tesofensine is not a psychiatric medication, its serotonergic effects suggest a potential risk with methylene blue.
Recommendation:
It is crucial to consult with a healthcare professional before combining methylene blue and tesofensine. They can assess the potential risks and benefits of this combination based on your individual health status and other medications you may be taking
 
Skidude said:
Your story seems similar to mine..
A few things that worked for me:
Diet- Lots of protein, chicken breast, yogurt, shakes, bars 120+ daily at 1200 calories
Lots of fluids/electrolytes: liquid IV, black coffee, lots of water bottles

Other stacks, SS-31, Lipo-c w/b12, Mots-C, Nad+
adding TMG and Coq10 supplement

Has helped w/ fatigue, and consistent loss
Click to expand...
Thanks this is helpful, can you share the brand for TMG you buy? Definitely want to add this
 
chmuse said:
Why are you choosing to stop the sema?

Cagri makes a lot of people tired. Drop it and just increase the reta. If you're not consuming enough, why add cagri? Reta does it's magic even while you eat.

Try to focus on protein. I know I get full fast so I eat the protein portion of my meal first, then move on to the veggies/grains/whatever.

I'm currently experimenting with ss31.... I'm yolo-ing it a little and following the first protocol I saw multiple people saying they like. Do your research, do you even need it? Or are you just doing it because all the cool kids are? (That's not an insult- just something to think about.)
Click to expand...
I’m guessing it’s because it curbs my appetite and then helps make conscious, healthy decisions. Food cravings seem to cause binge eating for me, although it’s become non existent with these medications. I have some anxiety with getting off sema and getting hit with crazy food hunger.

I want to try to move away from sema due to continued constipation. I’ve tried many different things but would like to see if it’s different with other peptides.

the fatigue has been improved this week but maybe I will try reta alone for a while.

Also, to add, I did a lot of drugs and smoked a lot in my early 20s and have always struggled with fatigue and brain fog. So I wouldn’t say I’m looking into it to be cool (although that may be an outcome with more energy 😂). I guess I truly want to feel better with more energy.

I think taking the reta alone for a while would be good as I’d be able to eat more. I’ll add shakes and purchase some electrolytes
 
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Skidude said:
  • Methylene Blue and Serotonin Syndrome: Methylene blue is a monoamine oxidase inhibitor (MAOI), particularly affecting MAO-A. This means it can increase serotonin levels in the brain.
Important Note:
The Food and Drug Administration (FDA) has issued warnings about combining methylene blue with serotonergic psychiatric medications due to the risk of serotonin syndrome. While tesofensine is not a psychiatric medication, its serotonergic effects suggest a potential risk with methylene
Click to expand...
The dosage to get you to serotonin syndrome is so high that I don't find any stories or cases of it happening in the real world.
 
a
Skidude said:
I have only seen one issue with the methylene blue, and that was with Tesofensine. As Teso was part of my stack I did not research it further. However there does not immediately appear to be an issue with mixing it with this stack as long as you are not taking any SSRIs. I cannot speak towards this in any detail as I am not aware and have not read in detail. Here is what I read about Teso and Methylene blue:

The combination of methylene blue and tesofensine is not specifically addressed in the provided search results. However, the information available regarding methylene blue and other serotonergic drugs raises concerns about potential interactions.
Understanding the Potential Risks
  • Methylene Blue and Serotonin Syndrome: Methylene blue is a monoamine oxidase inhibitor (MAOI), particularly affecting MAO-A. This means it can increase serotonin levels in the brain.
  • Serotonergic Drugs and Serotonin Syndrome: Many antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), increase serotonin levels. Combining them with MAOIs like methylene blue can lead to a dangerous condition called serotonin syndrome.
  • Tesofensine's Mechanism: Tesofensine is a triple monoamine reuptake inhibitor (serotonin, norepinephrine, and dopamine). It's primarily studied for potential use in obesity treatment.
Why This Combination Could Be Risky:
Since tesofensine increases serotonin levels, combining it with methylene blue, which also increases serotonin levels by inhibiting its breakdown, could potentially lead to excessive serotonin accumulation in the brain. This could result in serotonin syndrome, a potentially life-threatening condition.
Serotonin Syndrome Symptoms:
Serotonin syndrome can cause a range of symptoms, including:
  • Mental changes (confusion, agitation)
  • Muscle problems (twitching, rigidity)
  • Autonomic nervous system issues (fever, sweating, increased heart rate)
Important Note:
The Food and Drug Administration (FDA) has issued warnings about combining methylene blue with serotonergic psychiatric medications due to the risk of serotonin syndrome. While tesofensine is not a psychiatric medication, its serotonergic effects suggest a potential risk with methylene blue.
Recommendation:
It is crucial to consult with a healthcare professional before combining methylene blue and tesofensine. They can assess the potential risks and benefits of this combination based on your individual health status and other medications you may be taking
Click to expand...
Thank you for this info. I have been researching methylene blue and taking it for 6 mo and this is all correct. I've had the most benefits in my health, energy and cognitive functions with methylene blue than anything so far. Im currently on a 21mg daily and 28mg when there is added stress or recovery needs. I take no SSRI's or inhalers (epinephrine). I had not intended on taking Tesofensine but the information is very appreciated because I had not thought to look into peptides that could increase serotonin levels which is what I need to stay away from. I am surprised at my low 250mcg of the SS-31 that I am as tired and heavy feeling as I am. I ordered the TMG and CoQ10 and will start it tomorrow to see if there is improvement. Also interesting side note is I have pee'd way less blue than normal in the 3 days of being on SS-31 which makes me wonder if the Blue is allowing SS-31 easier access into the cell and overwhelming the mitocondria with to much activity. I am 46, carnivore/high protein, lots of water and vitamins and minerals and work out 4-6 days a week and in generally good health to round out my full TMI lol. Hope someone finds this chat helpful and I will update tomorrow.
 
Jenn67 said:
Literally reading about Teso. Is it ok to stack with Tirz?
Click to expand...
I "felt" fine while on it and took it for six to eight weeks, I even liked it. That said, I was concerned wtih potential issues:

Tesofensine is interesting and with it's triple effects:
  • It works by blocking the reuptake (reabsorption) of three key neurotransmitters: serotonin, norepinephrine, and dopamine.
I had no obvious issue and did not find any interaction warning with GLP1.
It does have an extremely long half life and comes with similar warnings you might find in other SSRIs.
I would suggest anyone interested, approach with caution, if you have a history of any mental issues and if not approach conservatively with 250mcg to begin and perhaps not over.
Some online info:
While Tesofensine is primarily being investigated for its potential as a weight-loss medication, its effects on mood, including depression, are a topic of interest and require further research.
Here's a breakdown of what's known about Tesofensine and depression:
1. Mechanism of Action and Potential Mood Effects:
  • Tesofensine is a triple monoamine reuptake inhibitor, increasing the levels of serotonin, norepinephrine, and dopamine in the brain.
  • These neurotransmitters are involved in regulating mood, and their increased availability is a mechanism shared with many antidepressant medications.
  • Therefore, there's a theoretical possibility that Tesofensine could have some antidepressant effects, or at least influence mood.
2. Evidence from Clinical Trials:
  • Clinical trials focused on Tesofensine for obesity have primarily assessed weight loss and safety, not specifically its impact on depression.
  • Some studies have reported a potential for increased anger, hostility, and confusion at higher doses of Tesofensine.
  • One study reported a small increase in depressed mood in some participants taking Tesofensine, but overall changes in mood were not consistently observed.
  • It's important to note that these trials were not designed to evaluate Tesofensine as an antidepressant, and more comprehensive studies are needed to determine its impact on mood.
3. Considerations and Cautions:
  • Tesofensine is not currently approved for the treatment of depression or any other mood disorder.
  • Individuals with a history of mental health disorders should discuss the potential risks and benefits of Tesofensine with their healthcare provider before considering it.
  • Tesofensine has been associated with side effects like dry mouth, insomnia, and increased heart rate, which could potentially impact mood and well-being.
In conclusion: While Tesofensine's mechanism of action suggests a potential for mood-related effects, including possibly influencing depression, current evidence is limited and more research is needed. It's essential to consult with a healthcare professional to discuss the potential risks and benefits of Tesofensine, especially for individuals with a history of mental health concerns.
 
Skidude said:
I "felt" fine while on it and took it for six to eight weeks, I even liked it. That said, I was concerned wtih potential issues:

Tesofensine is interesting and with it's triple effects:
  • It works by blocking the reuptake (reabsorption) of three key neurotransmitters: serotonin, norepinephrine, and dopamine.
I had no obvious issue and did not find any interaction warning with GLP1.
It does have an extremely long half life and comes with similar warnings you might find in other SSRIs.
I would suggest anyone interested, approach with caution, if you have a history of any mental issues and if not approach conservatively with 250mcg to begin and perhaps not over.
Some online info:
While Tesofensine is primarily being investigated for its potential as a weight-loss medication, its effects on mood, including depression, are a topic of interest and require further research.
Here's a breakdown of what's known about Tesofensine and depression:
1. Mechanism of Action and Potential Mood Effects:
  • Tesofensine is a triple monoamine reuptake inhibitor, increasing the levels of serotonin, norepinephrine, and dopamine in the brain.
  • These neurotransmitters are involved in regulating mood, and their increased availability is a mechanism shared with many antidepressant medications.
  • Therefore, there's a theoretical possibility that Tesofensine could have some antidepressant effects, or at least influence mood.
2. Evidence from Clinical Trials:
  • Clinical trials focused on Tesofensine for obesity have primarily assessed weight loss and safety, not specifically its impact on depression.
  • Some studies have reported a potential for increased anger, hostility, and confusion at higher doses of Tesofensine.
  • One study reported a small increase in depressed mood in some participants taking Tesofensine, but overall changes in mood were not consistently observed.
  • It's important to note that these trials were not designed to evaluate Tesofensine as an antidepressant, and more comprehensive studies are needed to determine its impact on mood.
3. Considerations and Cautions:
  • Tesofensine is not currently approved for the treatment of depression or any other mood disorder.
  • Individuals with a history of mental health disorders should discuss the potential risks and benefits of Tesofensine with their healthcare provider before considering it.
  • Tesofensine has been associated with side effects like dry mouth, insomnia, and increased heart rate, which could potentially impact mood and well-being.
In conclusion: While Tesofensine's mechanism of action suggests a potential for mood-related effects, including possibly influencing depression, current evidence is limited and more research is needed. It's essential to consult with a healthcare professional to discuss the potential risks and benefits of Tesofensine, especially for individuals with a history of mental health concerns.
Click to expand...
I weaned off my Vyvanse due to shortage of generic recently. Was hoping to see if Tesofensine would work instead. I have blood sugar spike with Vyvanse. Have not taken it since i started Reta either. Curious to see.
 
kris10karma said:
I weaned off my Vyvanse due to shortage of generic recently. Was hoping to see if Tesofensine would work instead. I have blood sugar spike with Vyvanse. Have not taken it since i started Reta either. Curious to see.
Click to expand...
I appreciate all the info in the article however one of the big things to consider with things that increase serotonin levels (tesofensine) is to not stack any 2 together so If you are on any SSRI's (antidepressants) or anything that increases your serotonin uptake like Methylene Blue do not take them together. Also be aware of anything that might raise your heart rate like an epinephrine (inhaler) with a stimulating agent like Methylene blue or Vyvanse. I don't take tesofensine because Methylene Blue is king in my world after HRT optimization. So everything else has to play nice with it because I get the most benefits from it (21mg oral). I have lots of people in my world that are ADD autistic and everything in between that get a huge benefit from Methylene blue for stress, energy, mental clarity and attention span. You stay on it every day and don't need to cycle off so you have better coverage year around. If you haven't tried it give it a shot. We buy ours on amazon for $30 for 60 capsules from "Nutricel Supplements". My husband takes a pill form and I take a Liquid form and they are both great. Start super low (4-7mg per day) then work your way up to what is good for you but I wouldn't go over 30 mg although some studies say it can be generally tolerated up to 50mg per day. Our sweet spot seems to be around 20-25 unless you're recovering from work out, sick, injured, post surgery then we kick it up to 28-35mg for a day or two. If you're young (<35) you might have the same benefits with just 12mg. If you haven't gone down the road of SS-31 I would also give it a go so you can get max benefits for your mitochondria but it doesn't play as nice with the MB's higher doses so maybe do a cycle of the SS-31 before or after your MB journey. Long story longer.. Good luck my friend
 
Tilted Halo said:
I appreciate all the info in the article however one of the big things to consider with things that increase serotonin levels (tesofensine) is to not stack any 2 together so If you are on any SSRI's (antidepressants) or anything that increases your serotonin uptake like Methylene Blue do not take them together. Also be aware of anything that might raise your heart rate like an epinephrine (inhaler) with a stimulating agent like Methylene blue or Vyvanse. I don't take tesofensine because Methylene Blue is king in my world after HRT optimization. So everything else has to play nice with it because I get the most benefits from it (21mg oral). I have lots of people in my world that are ADD autistic and everything in between that get a huge benefit from Methylene blue for stress, energy, mental clarity and attention span. You stay on it every day and don't need to cycle off so you have better coverage year around. If you haven't tried it give it a shot. We buy ours on amazon for $30 for 60 capsules from "Nutricel Supplements". My husband takes a pill form and I take a Liquid form and they are both great. Start super low (4-7mg per day) then work your way up to what is good for you but I wouldn't go over 30 mg although some studies say it can be generally tolerated up to 50mg per day. Our sweet spot seems to be around 20-25 unless you're recovering from work out, sick, injured, post surgery then we kick it up to 28-35mg for a day or two. If you're young (<35) you might have the same benefits with just 12mg. If you haven't gone down the road of SS-31 I would also give it a go so you can get max benefits for your mitochondria but it doesn't play as nice with the MB's higher doses so maybe do a cycle of the SS-31 before or after your MB journey. Long story longer.. Good luck my friend
Click to expand...
Thank you so much for the info. My bottle of tesofensine is just chilling on my desk. I am doing a round of ss-31, mots, nad+ coming up as soon as my cycle of glow and kpv end. I'm really mindful or combing things. I am on HRT and we are actively monitoring that. My practitioner is very much about feels over blood work unless the numbers go super whacky so Im trying not to turn too many dials. Optimal hormones are the baseline for health. Im 48 so definitely focusing on anti-aging and biohacking. Perimonopause effed off what was well controlled adhd. Im finally starting to feel a bit better. What worked 10 years ago for diet, sleep and exercise just dont anymore. On paper, I'm healthy AF but I knew I could do better. Your insight is appreciated.
 
kris10karma said:
Thank you so much for the info. My bottle of tesofensine is just chilling on my desk. I am doing a round of ss-31, mots, nad+ coming up as soon as my cycle of glow and kpv end. I'm really mindful or combing things. I am on HRT and we are actively monitoring that. My practitioner is very much about feels over blood work unless the numbers go super whacky so Im trying not to turn too many dials. Optimal hormones are the baseline for health. Im 48 so definitely focusing on anti-aging and biohacking. Perimonopause effed off what was well controlled adhd. Im finally starting to feel a bit better. What worked 10 years ago for diet, sleep and exercise just dont anymore. On paper, I'm healthy AF but I knew I could do better. Your insight is appreciated.
Click to expand...
I hear ya, Im right along with you at 46, If I could suggest something, hold off on your mots until after ss-31 cycle so you know your going to get the most benefits out of the mots. Some say mots is not as effective until after the ss-31 has gone in and done any repairs first. That is where I am in my second week of NAD (2x a week) and ss-31 (5 on 2 off). So far in my opinion nothing does near the work of the Methylene blue in energy, mental clarity, ADD and just mental feeling good so that's disappointing. Im wondering if the raving about all the benefits of peptides is because people have not found MB lol. I would love to find someone who was a MB user and then added peptides and got greater results to chime in. Also my ADD kids all do really well on MB so it's something to think about if you have kids that are dealing with it. (They are all between 21-26 yrs).
 
Tilted Halo said:
I hear ya, Im right along with you at 46, If I could suggest something, hold off on your mots until after ss-31 cycle so you know your going to get the most benefits out of the mots. Some say mots is not as effective until after the ss-31 has gone in and done any repairs first. That is where I am in my second week of NAD (2x a week) and ss-31 (5 on 2 off). So far in my opinion nothing does near the work of the Methylene blue in energy, mental clarity, ADD and just mental feeling good so that's disappointing. Im wondering if the raving about all the benefits of peptides is because people have not found MB lol. I would love to find someone who was a MB user and then added peptides and got greater results to chime in. Also my ADD kids all do really well on MB so it's something to think about if you have kids that are dealing with it. (They are all between 21-26 yrs).
Click to expand...
Some of us know the blue...

I ran the SS-31 at 5mg daily for 20 days, then right on to Mots-c, so I can't say if one impacted the other. Im glad I did both because I felt better after SS-31 in an indescribable way, and Mots-c has given me energy that won't allow me to plop on the couch when I could be doing anything else. It's not a jittery energy, but a desire to burn energy... I live all of the above mentioned remedies.

I also stacked 500mg of DSIP, but just tried a 10mg bottle. Either 20 doses won't get er done, or it's snake oil to me...
 

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Peloma said:
Some of us know the blue...

I ran the SS-31 at 5mg daily for 20 days, then right on to Mots-c, so I can't say if one impacted the other. Im glad I did both because I felt better after SS-31 in an indescribable way, and Mots-c has given me energy that won't allow me to plop on the couch when I could be doing anything else. It's not a jittery energy, but a desire to burn energy... I live all of the above mentioned remedies.

I also stacked 500mg of DSIP, but just tried a 10mg bottle. Either 20 doses won't get er done, or it's snake oil to me...
Click to expand...
I find i sleep much more sound on dsip. Doesn't make me sleepy at all but I feel more rested. Excellent results with my daughter too as far as sleep quality.
 
Peloma said:
Some of us know the blue...

I ran the SS-31 at 5mg daily for 20 days, then right on to Mots-c, so I can't say if one impacted the other. Im glad I did both because I felt better after SS-31 in an indescribable way, and Mots-c has given me energy that won't allow me to plop on the couch when I could be doing anything else. It's not a jittery energy, but a desire to burn energy... I live all of the above mentioned remedies.

I also stacked 500mg of DSIP, but just tried a 10mg bottle. Either 20 doses won't get er done, or it's snake oil to me...
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I LOVE IT!!! What's your MB mg per day and did you take it while doing ss-31? If so did you have to lower the dose of MB?
 
Tilted Halo said:
I LOVE IT!!! What's your MB mg per day and did you take it while doing ss-31? If so did you have to lower the dose of MB?
Click to expand...
Actually started 10mg (20 drops) when i started the Mots-c regiment. I figured since Ss-31 was repairing the mitochondria, I didn't want to alter the energy transfer within the cells until that job was done. Once that part was done, I used the Mots-c to ramp up the energy, and the MB is used to make sure the balance of energy is established and optimized.

It gives me the feels I was hoping for when I started the mitochondrial protocol.

I'm now on 20mg every other day of MB. Sometimes I take an extra 20 if the back end of the day is dragging.
 
Peloma said:
Actually started 10mg (20 drops) when i started the Mots-c regiment. I figured since Ss-31 was repairing the mitochondria, I didn't want to alter the energy transfer within the cells until that job was done. Once that part was done, I used the Mots-c to ramp up the energy, and the MB is used to make sure the balance of energy is established and optimized.

It gives me the feels I was hoping for when I started the mitochondrial protocol.

I'm now on 20mg every other day of MB. Sometimes I take an extra 20 if the back end of the day is dragging.
Click to expand...
That's awesome. Im having to drop down and space out the MB for sure for now until I am done with the ss cycle. Thank you for your info! #TheMoreYouKnow
 
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