Stacking peptides with SS-31

[Amuse84]

I think I’m going to start ss31. I purchased some MotsC but didn’t feel much. Watched this guys video - https://www.tiktok.com/t/ZP86fEfs4/

- plus read posts on here and Reddit so was going to stop the Mots and order some ss31.

I’m currently switching off Sema (been on it for about 7 months through a compounding pharmacy, lost 40 lbs) to Reta and added Cagri. Been so damn tired. I also work nights though plus really struggle with eating enough. Besides a lack of calories, my diet is AMAZING. Like never before. I’ve struggled terribly with a binge eating disorder most of my life. Currently eating salads every day, fruit, veggies, learn meat. When I snack I eat healthy. I have maybe a cheat meal a week when I go out with friends, but am even getting better with choosing healthier options when out. It’s just so easy to choose healthy. Yet, I’m still not able to consume enough. Still have super low energy (this started with the cagri about 2 weeks ago) I’ve had to cut back on my workouts because I know it’s not good to workout without calories plus I’m beyond tired lately. My calorie intake recently has ranged from 900 to 1500. On a good day I’ll get 100g of protein but on back day maybe 40g. It’s hard to manage all of this, was even thinking about doing a coaching session for maybe some help.

Would love to read any updates or experience from others. What has helped you eat enough or snacks? Whats worked or not working. how do you manage figuring all of this out and staying on track

 

[Skidude]

I think I’m going to start ss31. I purchased some MotsC but didn’t feel much. Watched this guys video - https://www.tiktok.com/t/ZP86fEfs4/

- plus read posts on here and Reddit so was going to stop the Mots and order some ss31.

I’m currently switching off Sema (been on it for about 7 months through a compounding pharmacy, lost 40 lbs) to Reta and added Cagri. Been so damn tired. I also work nights though plus really struggle with eating enough. Besides a lack of calories, my diet is AMAZING. Like never before. I’ve struggled terribly with a binge eating disorder most of my life. Currently eating salads every day, fruit, veggies, learn meat. When I snack I eat healthy. I have maybe a cheat meal a week when I go out with friends, but am even getting better with choosing healthier options when out. It’s just so easy to choose healthy. Yet, I’m still not able to consume enough. Still have super low energy (this started with the cagri about 2 weeks ago) I’ve had to cut back on my workouts because I know it’s not good to workout without calories plus I’m beyond tired lately. My calorie intake recently has ranged from 900 to 1500. On a good day I’ll get 100g of protein but on back day maybe 40g. It’s hard to manage all of this, was even thinking about doing a coaching session for maybe some help.

Would love to read any updates or experience from others. What has helped you eat enough or snacks? Whats worked or not working. how do you manage figuring all of this out and staying on track

Your story seems similar to mine..
A few things that worked for me:
Diet- Lots of protein, chicken breast, yogurt, shakes, bars 120+ daily at 1200 calories
Lots of fluids/electrolytes: liquid IV, black coffee, lots of water bottles

Other stacks, SS-31, Lipo-c w/b12, Mots-C, Nad+
adding TMG and Coq10 supplement

Has helped w/ fatigue, and consistent loss

 

[zpped]

Just drop the cagri. You're having negative side effects and should be simplifying things not complicating them.

 

[chmuse]

Why are you choosing to stop the sema?

Cagri makes a lot of people tired. Drop it and just increase the reta. If you're not consuming enough, why add cagri? Reta does it's magic even while you eat.

Try to focus on protein. I know I get full fast so I eat the protein portion of my meal first, then move on to the veggies/grains/whatever.

I'm currently experimenting with ss31.... I'm yolo-ing it a little and following the first protocol I saw multiple people saying they like. Do your research, do you even need it? Or are you just doing it because all the cool kids are? (That's not an insult- just something to think about.)

 

[Peloma]

No need to chime in about cagri. Those are good answers above.

The SS-31 gave me a feeling that something was actually "working" on me. It's a good feeling. I ran 5mg for 5 days on, 2 days off for 5 weeks (100mg) followed by the Mots-c protocol I'm on now. Mots-c is 6mg mon and wed, 8mg fri (20mg weekly) for 5 weeks.

Mots-c has given me more get up go motivation, but I feel like the SS-31 prepared my engine to run high power fuel. Otherwise, I'm not sure I'd get as good an effect.

 

[Tilted Halo]

Your story seems similar to mine..
A few things that worked for me:
Diet- Lots of protein, chicken breast, yogurt, shakes, bars 120+ daily at 1200 calories
Lots of fluids/electrolytes: liquid IV, black coffee, lots of water bottles

Other stacks, SS-31, Lipo-c w/b12, Mots-C, Nad+
adding TMG and Coq10 supplement

Has helped w/ fatigue, and consistent loss

Just started SS-31(3rd day) and I am so dang tired! Only currently on NAD and methylene blue. So you think the TMG and Coq10 helped you with that?

 

[Skidude]

It is challenging to pin point the advantages of these for energy, the entire stack was initiated to help support the process of various peps as I read that the SS-31 would basically optimize the MOTS in the eventual addition to it after 4 weeks on ss-31. I will say ensuring that I had adequate proteins and fluids was likely the most positive influence on the feels. Most of the discussions I have seen surrounding fatigue were either diet based or stronger peps/etc to create energy.
The effects of this stack were subtle in the way they "felt".

The protocol i followed was basically:

Taking TMG (trimethylglycine) alongside NAD+ supplements like NMN (nicotinamide mononucleotide) can help maintain healthy methylation levels, which are essential for various bodily functions. TMG acts as a methyl donor, replenishing methyl groups that can be depleted by NAD+ precursors. This can ensure optimal cellular energy production, anti-aging processes, and other benefits associated with NAD+ supplementation.


Here's a more detailed explanation:

• Methylation and its Importance:
  Methylation is a crucial process involving the transfer of methyl groups, which are a methyl group consisting of a carbon atom bonded to three hydrogen atoms, to other molecules. It plays a role in DNA repair, neurotransmission, and other vital functions.
  
  
• NAD+ and Methylation:
  NAD+ (nicotinamide adenine dinucleotide) is a key molecule involved in energy metabolism and cellular processes. When NAD+ precursors like NMN are taken, they can increase NAD+ levels, which also increases the production of methylnicotinamide (MeNAM).
  
  
• TMG's Role:
  TMG provides methyl groups that can be used in these processes, including the conversion of NAD+ to MeNAM. If the body doesn't have enough methyl groups, it can compromise methylation processes, potentially diminishing the benefits of NAD+ supplements or causing other health issues.
  
  
• Why TMG with NAD+?
  By supplementing with TMG alongside NMN, individuals can ensure they have adequate methyl groups to support methylation processes, potentially enhancing the benefits of NAD+ supplementation and promoting overall health.
  
  
• David Sinclair's Approach:
  Dr. David Sinclair, a prominent researcher in aging, takes TMG as a precautionary measure when supplementing with NMN.
  
  
• Potential Benefits:
  The combination of TMG and NAD+ supplements may support cardiovascular health, boost athletic performance, and regulate insulin levels.

 

[Skidude]

Just started SS-31(3rd day) and I am so dang tired! Only currently on NAD and methylene blue. So you think the TMG and Coq10 helped you with that?

And on the CoQ10

Coenzyme Q10 (CoQ10) can enhance the effects of other supplements, particularly those related to heart health, exercise, and overall well-being. It works by boosting energy production, reducing oxidative stress, and improving nutrient absorption, thus supporting the function of other supplements.
Here's how CoQ10 can synergize with other supplements:

• Cardiovascular Health:
  .Opens in new tab
  CoQ10 is a crucial component of the electron transport chain, essential for energy production in cells, especially in the heart. It can be combined with other heart-healthy supplements like omega-3 fatty acids, magnesium, or red yeast rice to further support cardiovascular function.
  
  
• Exercise Performance:
  .Opens in new tab
  CoQ10 can improve mitochondrial function, which is vital for energy production in muscle cells. Combining it with other supplements like creatine or arginine can enhance muscle power and reduce fatigue during exercise.
  
  
• Antioxidant Support:
  .Opens in new tab
  CoQ10 is a powerful antioxidant that helps protect cells from damage caused by free radicals. It can work synergistically with other antioxidants like vitamin C, vitamin E, or astaxanthin to provide comprehensive protection against oxidative stress.
  
  
• Overall Health:
  .Opens in new tab
  CoQ10 may also enhance the absorption and utilization of other nutrients, such as vitamin D or riboflavin, contributing to overall well-being.

Coenzyme Q10 (CoQ10) and SS-31 are both associated with mitochondrial health and function, but they work in different ways. CoQ10 is a natural antioxidant that plays a key role in the electron transport chain, while SS-31 is a mitochondria-targeted peptide that reduces oxidative stress and improves mitochondrial function.

Coenzyme Q10 (CoQ10):

• Role:
  CoQ10 is a crucial component of the electron transport chain within mitochondria, which is responsible for generating energy (ATP).
  
  
• Function:
  It acts as an antioxidant, helping to protect cells from damage caused by free radicals.
  
  
• Potential benefits:
  Supplementation with CoQ10 has been linked to various benefits, including improved cardiovascular health and increased energy levels.

In summary:

• CoQ10 is a natural antioxidant involved in the electron transport chain, while SS-31 is a mitochondria-targeted peptide with antioxidant and mitochondrial protective effects.
  
  
• Both CoQ10 and SS-31 have potential benefits for mitochondrial health and function, but they work through different mechanisms.
  
  
• SS-31 has shown promise in animal models of various diseases, while CoQ10 supplementation is linked to benefits like improved cardiovascular health and increased energy levels.

 

[Skidude]

Just started SS-31(3rd day) and I am so dang tired! Only currently on NAD and methylene blue. So you think the TMG and Coq10 helped you with that?

I have only seen one issue with the methylene blue, and that was with Tesofensine. As Teso was part of my stack I did not research it further. However there does not immediately appear to be an issue with mixing it with this stack as long as you are not taking any SSRIs. I cannot speak towards this in any detail as I am not aware and have not read in detail. Here is what I read about Teso and Methylene blue:

The combination of methylene blue and tesofensine is not specifically addressed in the provided search results. However, the information available regarding methylene blue and other serotonergic drugs raises concerns about potential interactions.
Understanding the Potential Risks

• Methylene Blue and Serotonin Syndrome: Methylene blue is a monoamine oxidase inhibitor (MAOI), particularly affecting MAO-A. This means it can increase serotonin levels in the brain.
• Serotonergic Drugs and Serotonin Syndrome: Many antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), increase serotonin levels. Combining them with MAOIs like methylene blue can lead to a dangerous condition called serotonin syndrome.
• Tesofensine's Mechanism: Tesofensine is a triple monoamine reuptake inhibitor (serotonin, norepinephrine, and dopamine). It's primarily studied for potential use in obesity treatment.

Why This Combination Could Be Risky:
Since tesofensine increases serotonin levels, combining it with methylene blue, which also increases serotonin levels by inhibiting its breakdown, could potentially lead to excessive serotonin accumulation in the brain. This could result in serotonin syndrome, a potentially life-threatening condition.
Serotonin Syndrome Symptoms:
Serotonin syndrome can cause a range of symptoms, including:

• Mental changes (confusion, agitation)
• Muscle problems (twitching, rigidity)
• Autonomic nervous system issues (fever, sweating, increased heart rate)

Important Note:
The Food and Drug Administration (FDA) has issued warnings about combining methylene blue with serotonergic psychiatric medications due to the risk of serotonin syndrome. While tesofensine is not a psychiatric medication, its serotonergic effects suggest a potential risk with methylene blue.
Recommendation:
It is crucial to consult with a healthcare professional before combining methylene blue and tesofensine. They can assess the potential risks and benefits of this combination based on your individual health status and other medications you may be taking

 

[Amuse84]

Your story seems similar to mine..
A few things that worked for me:
Diet- Lots of protein, chicken breast, yogurt, shakes, bars 120+ daily at 1200 calories
Lots of fluids/electrolytes: liquid IV, black coffee, lots of water bottles

Other stacks, SS-31, Lipo-c w/b12, Mots-C, Nad+
adding TMG and Coq10 supplement

Has helped w/ fatigue, and consistent loss

Thanks this is helpful, can you share the brand for TMG you buy? Definitely want to add this

 

[Amuse84]

Why are you choosing to stop the sema?

Cagri makes a lot of people tired. Drop it and just increase the reta. If you're not consuming enough, why add cagri? Reta does it's magic even while you eat.

Try to focus on protein. I know I get full fast so I eat the protein portion of my meal first, then move on to the veggies/grains/whatever.

I'm currently experimenting with ss31.... I'm yolo-ing it a little and following the first protocol I saw multiple people saying they like. Do your research, do you even need it? Or are you just doing it because all the cool kids are? (That's not an insult- just something to think about.)

I’m guessing it’s because it curbs my appetite and then helps make conscious, healthy decisions. Food cravings seem to cause binge eating for me, although it’s become non existent with these medications. I have some anxiety with getting off sema and getting hit with crazy food hunger.

I want to try to move away from sema due to continued constipation. I’ve tried many different things but would like to see if it’s different with other peptides.

the fatigue has been improved this week but maybe I will try reta alone for a while.

Also, to add, I did a lot of drugs and smoked a lot in my early 20s and have always struggled with fatigue and brain fog. So I wouldn’t say I’m looking into it to be cool (although that may be an outcome with more energy ). I guess I truly want to feel better with more energy.

I think taking the reta alone for a while would be good as I’d be able to eat more. I’ll add shakes and purchase some electrolytes

 

[Peloma]

• Methylene Blue and Serotonin Syndrome: Methylene blue is a monoamine oxidase inhibitor (MAOI), particularly affecting MAO-A. This means it can increase serotonin levels in the brain.

Important Note:
The Food and Drug Administration (FDA) has issued warnings about combining methylene blue with serotonergic psychiatric medications due to the risk of serotonin syndrome. While tesofensine is not a psychiatric medication, its serotonergic effects suggest a potential risk with methylene

The dosage to get you to serotonin syndrome is so high that I don't find any stories or cases of it happening in the real world.

 

[Tilted Halo]

a

I have only seen one issue with the methylene blue, and that was with Tesofensine. As Teso was part of my stack I did not research it further. However there does not immediately appear to be an issue with mixing it with this stack as long as you are not taking any SSRIs. I cannot speak towards this in any detail as I am not aware and have not read in detail. Here is what I read about Teso and Methylene blue:

The combination of methylene blue and tesofensine is not specifically addressed in the provided search results. However, the information available regarding methylene blue and other serotonergic drugs raises concerns about potential interactions.
Understanding the Potential Risks

• Methylene Blue and Serotonin Syndrome: Methylene blue is a monoamine oxidase inhibitor (MAOI), particularly affecting MAO-A. This means it can increase serotonin levels in the brain.
• Serotonergic Drugs and Serotonin Syndrome: Many antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), increase serotonin levels. Combining them with MAOIs like methylene blue can lead to a dangerous condition called serotonin syndrome.
• Tesofensine's Mechanism: Tesofensine is a triple monoamine reuptake inhibitor (serotonin, norepinephrine, and dopamine). It's primarily studied for potential use in obesity treatment.

Why This Combination Could Be Risky:
Since tesofensine increases serotonin levels, combining it with methylene blue, which also increases serotonin levels by inhibiting its breakdown, could potentially lead to excessive serotonin accumulation in the brain. This could result in serotonin syndrome, a potentially life-threatening condition.
Serotonin Syndrome Symptoms:
Serotonin syndrome can cause a range of symptoms, including:

• Mental changes (confusion, agitation)
• Muscle problems (twitching, rigidity)
• Autonomic nervous system issues (fever, sweating, increased heart rate)

Important Note:
The Food and Drug Administration (FDA) has issued warnings about combining methylene blue with serotonergic psychiatric medications due to the risk of serotonin syndrome. While tesofensine is not a psychiatric medication, its serotonergic effects suggest a potential risk with methylene blue.
Recommendation:
It is crucial to consult with a healthcare professional before combining methylene blue and tesofensine. They can assess the potential risks and benefits of this combination based on your individual health status and other medications you may be taking

Thank you for this info. I have been researching methylene blue and taking it for 6 mo and this is all correct. I've had the most benefits in my health, energy and cognitive functions with methylene blue than anything so far. Im currently on a 21mg daily and 28mg when there is added stress or recovery needs. I take no SSRI's or inhalers (epinephrine). I had not intended on taking Tesofensine but the information is very appreciated because I had not thought to look into peptides that could increase serotonin levels which is what I need to stay away from. I am surprised at my low 250mcg of the SS-31 that I am as tired and heavy feeling as I am. I ordered the TMG and CoQ10 and will start it tomorrow to see if there is improvement. Also interesting side note is I have pee'd way less blue than normal in the 3 days of being on SS-31 which makes me wonder if the Blue is allowing SS-31 easier access into the cell and overwhelming the mitocondria with to much activity. I am 46, carnivore/high protein, lots of water and vitamins and minerals and work out 4-6 days a week and in generally good health to round out my full TMI lol. Hope someone finds this chat helpful and I will update tomorrow.

 

[Skidude]

The dosage to get you to serotonin syndrome is so high that I don't find any stories or cases of it happening in the real world.

Yeah, I have no idea on that, but felt it was worth mentioning.