Retatrutide Fatigue/Sleepiness

Male here. Dang, I knew that would be important to add, thought I went back and edited that info, guess not. Typically my estrogen comes back at 37 to 40, the time I felt so bad on Reta it came back at 11.4.

I guess theoretically reta could lower estrogen by reducing fat-mediated conversion of T to E, but I never lost enough weight for that to take place. I will try reta again in the future and get bloods taken again regardless of how I feel.

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This is VERY interesting.

I just joined a female HRT + GLP -1 sub (I am F48 on HRT - estrogen, progesterone, testosterone) and the women there are saying their E tanked too on GLPs. 1-2 said their T spiked (not all female HRT for us includes T). I don’t recall offhand which GLP-1.

My provider treats to symptoms but watches blood levels for ratios.

Was your T higher than expected?
 
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I asked the Peptide Whisperer himself, Hunter Williams with his wife Taylor, on this morning’s YouTube live, about this exact question and they suggested adding NAD+ and MOTS-C into my stack. Since I already take NAD+, I shall be adding MOTS-C into the research. Let’s hope I get my energy levels back up. If not, I might go back to Tirzepatide.



ANY THOUGHTS FRIENDS? 🤔
How has the Mots-C worked for you? and the Nad+?
 
I haven’t tired MOTS-C yet and I am doing NAD+ and found no freedom from the fatigue demons. LOL.. Have you tried it?
No I was going to do the SS-31 first since I am older and definitelyhave Mito damage..but its on the list for right after that.
 
The reason people feel sluggish on these drugs is because you aren’t eating. Other peps might give you a boost but it’s artificial. We really need to focus on what we are consuming and that we have a balanced diet. We are starving ourselves on purpose here to lose weight. The GLPs just make us not think about it.
Forgive me for fangirling, but I just gotta say thank you. I snuck over here a couple of months ago (TikTok of course) and I started watching your comments on here. Gave me great direction. I don’t talk on here or come here much more at all. But I gotta say you’re so helpful! I figured it was a sign since I love pandas or something lol so uh, I guess I gotta thank you because my body is much happier two months in lol
 
Forgive me for fangirling, but I just gotta say thank you. I snuck over here a couple of months ago (TikTok of course) and I started watching your comments on here. Gave me great direction. I don’t talk on here or come here much more at all. But I gotta say you’re so helpful! I figured it was a sign since I love pandas or something lol so uh, I guess I gotta thank you because my body is much happier two months in lol
That’s very flattering. This community helps all of us. You are doing the work, and that’s why you feel better! Keep it up!
 
3 weeks into Reta, at 2mg/ 7 days right now. My experience so fas is that I need to be hypervigilant on what I eat and when. 30-45 mins before gym, whey protein shake (with almond milk) with a banana and a shot of espresso -- good energy for my workout. After gym, electrolyte drink, I use Propel fitness water packs. Next meal will have a min of 40g protein, low fat, moderate carb, trying to keep it around 450-500cal. Last meal will have 50g protein, lotsa veggies, and leave me with 200ish cals to spend on a greek yogurt/ frozen fruit smoothie. I work to be under 1800 cals/ day TDEE for me is 3,000.

So far I do notice a mild fatigue later in the day, worse if I am stuck at the desk working (I am a remote worker) and don't eat right, but not debilitating. I also acknowledge that I am new, and my dose is 2mg.
 
Same with the late afternoon fatigue. My job isn’t physically demanding either. Going to add in some more research soon to see if that assists with it.
 
My n=1, it is not lack of calories. I have microdosed all three (s, t, r)- less than half dose once/wk. I experienced “need to sleep an extra day” fatigue without much if any appetite suppression with all three.

I happens on day 2, and with eating the same each day, it’s something other than calories. It spilled into day 3 with sema. I lasted three weeks and had enough dark thoughts I stopped. I went to Reta next thinking it would help bolster energy levels, and it was down to one day of falling-asleep-upright fatigue but firmly there.

I did more reading/research and decided to take more electrolytes. Whatever the cause of loss, I know my system runs lean of them and that they might help with glp-1 fatigue.

I took liquid IV morning and evening of day one, morning of days two and three on a half dose of tirz and I am having FAR less fatigue. As in: Dosed on Friday PM, laid down for my usual Saturday nap and didn’t really need to sleep.

I’m VERY excited for this, it makes these peptides viable for me.

Pursue multiple causes of the fatigue. It may not be calorie count. Calorie timing and electrolytes are options, pay attention to when the fatigue comes and goes for clues.
Thanks for the feedback on this. I will be sure to watch electrolytes carefully. Now days that there are several options for electrolyte capsules, it has been a game changer for me. I can handle much more intake than i normally would.
 
I’ve been Keto for years and Carnivore for the last couple of years and love eating this way. I did notice I don’t feel the best doing Carnivore while on Tirzepatide/Retatrutide so I now allow for some carbs, but most meals eat no carbs.

Love that I’ve met another Keto/Carnivore brother on here. 😃 BLESSINGS..
Great stuff! Regards friend.
 
I don’t have the fatigue in ozempic I did.
What I have is insomnia
If I know I’m in for a rough night of sleep, I’ll take half of this sleep-specific gummy about an hour to an hour and a half before bed. I chew it up and let it sit under my tongue for as long as I can. I only use it when I’ve got a full 8 hours to sleep. I’m not a recreational cannabis user in the usual sense (don't like feeling like my brain is powered down while awake, probably why I have trouble sleeping), but for me, this works better than anything else I’ve tried.https://wyldcanna.com/us/products/boysenberry/
 
If I know I’m in for a rough night of sleep, I’ll take half of this sleep-specific gummy about an hour to an hour and a half before bed. I chew it up and let it sit under my tongue for as long as I can. I only use it when I’ve got a full 8 hours to sleep. I’m not a recreational cannabis user in the usual sense (don't like feeling like my brain is powered down while awake, probably why I have trouble sleeping), but for me, this works better than anything else I’ve tried.https://wyldcanna.com/us/products/boysenberry/
Wyld is an excellent brand.

The brain shutting down thing can be so bad and difficult to stop. My spouse suffers from over-thinking day and literally night. The sleep is rare and I cannot see how anyone can function this way.
 
If I know I’m in for a rough night of sleep, I’ll take half of this sleep-specific gummy about an hour to an hour and a half before bed. I chew it up and let it sit under my tongue for as long as I can. I only use it when I’ve got a full 8 hours to sleep. I’m not a recreational cannabis user in the usual sense (don't like feeling like my brain is powered down while awake, probably why I have trouble sleeping), but for me, this works better than anything else I’ve tried.https://wyldcanna.com/us/products/boysenberry/
My wife is like that, where if she has stuff on mind she can't sleep. Maybe i should get her some. I looked at the link and it makes sense to me that it is from Indica strain. If it was from sativa, you'd prolly start hearing things.. i haven't had either for a long time since i quit smoking cigs and don't wanna relapse, but it's the reason i think i've always liked pure sativa better.. it always pushes me towards activity/creativity while Indicas more towards couch lock.
 
If you are looking for something less illicit, I have been seeing blends like this lately…

‘Relaxation PM’
Gaba 100mg
Melatonin 1mg
Arginine 100mg
Glutamine 25mg

HYB has it for $160 per kit.
 
The reason people feel sluggish on these drugs is because you aren’t eating
I always respect your opinion but have to disagree on this one. I do fasting every now and then, no food just water (2-3 days) and my energy is through the roof. It actually is so high (the energy) that I can't even sleep or feel sleepy at all, and that is usually the reason I have to end the fast early, usually 2-3 days max (ideally would like to 6-7 days twice per year). So, I'm pretty sure there is other things at play that makes us feel tired on these fat lowering drugs but not qualified to give the proper answer.

However, I wonder if anyone has tried HGH while on GLP1's?

I'm having great success with HGH for muscle building/maintaining and energy but actually I stopped Reta and Tirze (before my HGH regimen) because Reta and Tirze gave me excruciating/crippling back pain. I was able to reduce the back pain almost to zero with 3mg's of LDN (Low dose Naltrexone) daily, but I am still not 100% pain free to start Reta and/or Tirze again.
 
I always respect your opinion but have to disagree on this one. I do fasting every now and then, no food just water (2-3 days) and my energy is through the roof. It actually is so high (the energy) that I can't even sleep or feel sleepy at all, and that is usually the reason I have to end the fast early, usually 2-3 days max (ideally would like to 6-7 days twice per year). So, I'm pretty sure there is other things at play that makes us feel tired on these fat lowering drugs but not qualified to give the proper answer.

However, I wonder if anyone has tried HGH while on GLP1's?

I'm having great success with HGH for muscle building/maintaining and energy but actually I stopped Reta and Tirze (before my HGH regimen) because Reta and Tirze gave me excruciating/crippling back pain. I was able to reduce the back pain almost to zero with 3mg's of LDN (Low dose Naltrexone) daily, but I am still not 100% pain free to start Reta and/or Tirze again.
I understand your perspective and it’s correct, but when you are talking about someone who is used to eating well over 2000 to 3000 calories per day, and now they are eating maybe 1200, it will definitely cause fatigue and effect mood.

As far as HGH, I take 3iu daily in addition to Tirz every 5 days. It doesn’t affect my energy levels that I can notice but it has helped with muscle growth. It can cause virilization in women though, so I encourage everyone to do thorough research on it before taking that leap.
 
and have noticed horrible fatigue/sleepiness.
I am not an expert by any stretch, but my opinion is that the fatigue comes as result of muscle wasting, however small that might be.

I would suggest you try HGH. I actually had to stop taking RETA and/or Tirze because had severe back paid on them, but I've been on HGH for about a month (started it after stopping GLP1's) and have gained most of my muscle back and have good energy level.

Maybe those that have done HGH while on GLP1's can chime in?
 
I understand your perspective and it’s correct, but when you are talking about someone who is used to eating well over 2000 to 3000 calories per day, and now they are eating maybe 1200, it will definitely cause fatigue and effect mood.
I hear you, in such cases you are correct. For me though which I usually don't consume more than 2000-2200 calories I think the loss of energy must have come from loss of muscle. While i had decent appetite suppression I didn't really cut the calories that much 1700-1800 at best, from 2000-2200. But I lost a lot of muscle and strength also. To be fair I did not exercise nearly enough, but my strength was less than 1/2 and my muscles were visibly smaller. As an example, pre Tirze and Reta I could do about 30 pushups (with max effort) and after being on Reta/Tirze for about 4 months I could barely do 7-8 push-ups. Thanks to about five weeks of HGH i am back to doing 25 and have gained about 90% of the muscle I lost.
 
I am not an expert by any stretch, but my opinion is that the fatigue comes as result of muscle wasting, however small that might be.

I would suggest you try HGH. I actually had to stop taking RETA and/or Tirze because had severe back paid on them, but I've been on HGH for about a month (started it after stopping GLP1's) and have gained most of my muscle back and have good energy level.

Maybe those that have done HGH while on GLP1's can chime in?
I’m going to set off a shit storm with this one, but if I could start over again, I would have taken a low dose of Anavar to preserve muscle. I would help with fatigue as well.
 
As far as HGH, I take 3iu daily
I've been doing 2-2.5IU daily for 5 days, but it is giving me edema on my right ankle. do you have any suggestions for edema, other than lowering the dose and titrating up slowly? There is no pain involved, but just looks weird/swollen LOL
 
low dose of Anavar to preserve muscle
Do you mind elaborating a bit on Anavar, i.e. dose you recommend and any possible sides or anything else you might suggest together with it. I've never taken steroids and I'm kind of scared of side effects especially for a newbie in that area.
 
I've been doing 2-2.5IU daily for 5 days, but it is giving me edema on my right ankle. do you have any suggestions for edema, other than lowering the dose and titrating up slowly? There is no pain involved, but just looks weird/swollen LOL
I would say lower the dose, especially if you are under 40. Another mitigation is more potassium and less salt, or switch to salt without iodine.
 
I would say lower the dose, especially if you are under 40. Another mitigation is more potassium and less salt, or switch to salt without iodine.
Thanks, Will try potassium and will lower salt intake (kinda makes sense). I'm actually over 50. Dang I was loving the effects at 2.5IU's and probably I might have to do 1IU for a while and see how it goes.
 
Do you mind elaborating a bit on Anavar, i.e. dose you recommend and any possible sides or anything else you might suggest together with it. I've never taken steroids and I'm kind of scared of side effects especially for a newbie in that area.
Anavar is a very mild AAS. It gets a bad rap because people abuse it and others. It’s definitely not toxic like trenbolone. When I take it about 30 minutes before a workout I 100% can feel a difference in strength and endurance. I think a good starting dose is 10mg. Titrate in increments of 5 mg and don’t go above 50mg per day. Monitor your BP and listen to your body. For men, take 1.5 mg a week Arimidex if you are concerned about estrogenic effects. Its liver toxicity is not terrible and you can mitigate with Glutathione and supposedly milk thistle.
 

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