Anhedonia... that blaaaaah feeling.

[miss-sanne]

So, I was on Tirz for a few months, all went well, good weight loss, minimal side effects, I do love Tirz so much. But at the higher doses 10-11 mg, I started to feel so flat, so bummed, depressed, and 'fuck you all, I'm gonna sit here and read reddit all the time', no will to do anything, no joy. Well I had to go to work, but when I got home, I was just like a 'blaaaaah'.
Apparently, a side effect from Tirz, I didn't have it on Sema.
Waited for at bit, but couldn't stand it.
Titrating down at the moment, going up in Reta, a bit of Cagri.
Feel better, have more energy on the other two.
But this could maybe happen again on Reta.
Does anyone know of any supplements etc, they have used or heard of, to help with this anhedonia ?
Thank you.

 

[Bunny]

Hello 👋 I don't know if this suggestion will help in any way. Just my personal experience. Happily on tirz for around 15 months when was slammed (bedridden 😞) with appalling anxiety - for no reason. Am now on a reduced dose of tirz with a small dose of sema mid week. No anxiety. Really it's a matter of trying different peps / blends / dosages. Everyone reacts differently. I'm confident there is a solution to this. Good luck 🤞

 

[miss-sanne]

Hello 👋 I don't know if this suggestion will help in any way. Just my personal experience. Happily on tirz for around 15 months when was slammed (bedridden 😞) with appalling anxiety - for no reason. Am now on a reduced dose of tirz with a small dose of sema mid week. No anxiety. Really it's a matter of trying different peps / blends / dosages. Everyone reacts differently. I'm confident there is a solution to this. Good luck 🤞

That's what I already do, I'm just curious about some solutions out there. That's sounds awful, being bedridden for anxiety !

 

[DwightTheDelight]

That's what I already do, I'm just curious about some solutions out there. That's sounds awful, being bedridden for anxiety !

Time was the solution in my case. I started at a higher dose of Tirz than most people and felt off for a few months. Those first 3 months felt like I just sat at my office desk or in a recliner and melted.

This went away, but anytime I would bump the dose up, I knew I would feel it for a bit again. It always went away. Eventually, I worked my way up to 15mg every 4/5 days and even at doses that high, I stopped feeling like that.

Hopefully, you'll have a similar outcome. GL

 

[miss-sanne]

Time was the solution in my case. I started at a higher dose of Tirz than most people and felt off for a few months. Those first 3 months felt like I just sat at my office desk or in a recliner and melted.

This went away, but anytime I would bump the dose up, I knew I would feel it for a bit again. It always went away. Eventually, I worked my way up to 15mg every 4/5 days and even at doses that high, I stopped feeling like that.

Hopefully, you'll have a similar outcome. GL

Thank you, but I could't live that way, it was too depressing, - why I went over to reta instead, hoping, it won't do it too.
glad to hear it worked out for you, maybe i'll try again sometime, since i have 3-4 years worth of tirz in the freezer, lol.

 

[DwightTheDelight]

Thank you, but I could't live that way, it was too depressing, - why I went over to reta instead, hoping, it won't do it too.
glad to hear it worked out too, maybe i'll try aain sometime, since i have 3-4 years worth of tirz in the freezer, lol.

I hear ya. Luckily, I'm too dumb to even realize anything was off - as it was happening. I only noticed after I started to return to normal and began wanting to do things again.

GL with reta. Hopefully it is kinder to you than Tirz was.

 

[miss-sanne]

I hear ya. Luckily, I'm too dumb to even realize anything was off - as it was happening. I only noticed after I started to return to normal and began wanting to do things again.

GL with reta. Hopefully it is kinder to you than Tirz was.

True, I didn't think about it at first, because well.... but after some time it got worse and worse, so I looked up side effects.

 

[andreigl]

Jesus, this is the first I heard about this. I thought only BPC-157 had issues like this. I take both tirzepatide and BPC-157.

What I do with BPC-157, is to take NAC too, it was said to help regulate serotonin/dopamine something something..

 

[Foggy-Hollow]

Miss-sanne this is the space I’m in: tirz plus NAD+.

I have tried all 3 of the current GLP-1s (short tries), and had anhedonia on all 3. On sema I got to week three and had to drop it, it was Very Much Not Good. It’s the reason I’ve tried all three, all short term partial doses.

As of today I’m 3 doses of tirz in, with roughly 3/week of NAD. So far it’s “okay” the anhedonia creeps through a tad here and there but the other morning I was cracking dad jokes at 6 am (definitely not my MO at F48, menopause-ish).

I have historically had anhedonia that dipped into depression. Seems likely that places me at greater tendency/ risk.

I am also not consistent with exercise (yet) and it’s a good weapon against this grey fog. 20 minutes of breath-moving activity (which a brisk walk works well for) was helpful for my “run of the mill” variety. Can’t say if it will help with this “induced” type but nothing to lose by trying.

My energy seems a little better than without, not sure it helps where really needed though, read: dopamine. When my energy dips I am definitely crankier than normal.

Jesus, this is the first I heard about this. I thought only BPC-157 had issues like this. I take both tirzepatide and BPC-157.

What I do with BPC-157, is to take NAC too, it was said to help regulate serotonin/dopamine something something..

Wait. NAC… do you mean NAD? Am I on the wrong planet and need to consider something different?

 

[nonyabizznez]

I feel better whenever a see a post from @DwightTheDelight!

Hope all is well! 🤗

 

[randompersonrandom]

Time was the solution in my case. I started at a higher dose of Tirz than most people and felt off for a few months. Those first 3 months felt like I just sat at my office desk or in a recliner and melted.

This went away, but anytime I would bump the dose up, I knew I would feel it for a bit again. It always went away. Eventually, I worked my way up to 15mg every 4/5 days and even at doses that high, I stopped feeling like that.

Hopefully, you'll have a similar outcome. GL

from your lips to god's ears. I've been pretending like I don't have this going on, but I'm starting to sort of be open to the possibility that I do. Working out more helps it, and it WAS starting to fade off when I bumped my dose a month ago, so I'm hoping if I just keep on keeping on, I'll be fabulously healthy AND not so flat.

 

[miss-sanne]

Jesus, this is the first I heard about this. I thought only BPC-157 had issues like this. I take both tirzepatide and BPC-157.

What I do with BPC-157, is to take NAC too, it was said to help regulate serotonin/dopamine something something..

uuhh nac, as a tablet /capsule ? how much and how many times per day ? Should be easy to get TODAY lol

 

[miss-sanne]

Miss-sanne this is the space I’m in: tirz plus NAD+.

I have tried all 3 of the current GLP-1s (short tries), and had anhedonia on all 3. On sema I got to week three and had to drop it, it was Very Much Not Good. It’s the reason I’ve tried all three, all short term partial doses.

As of today I’m 3 doses of tirz in, with roughly 3/week of NAD. So far it’s “okay” the anhedonia creeps through a tad here and there but the other morning I was cracking dad jokes at 6 am (definitely not my MO at F48, menopause-ish).

I have historically had anhedonia that dipped into depression. Seems likely that places me at greater tendency/ risk.

I am also not consistent with exercise (yet) and it’s a good weapon against this grey fog. 20 minutes of breath-moving activity (which a brisk walk works well for) was helpful for my “run of the mill” variety. Can’t say if it will help with this “induced” type but nothing to lose by trying.

My energy seems a little better than without, not sure it helps where really needed though, read: dopamine. When my energy dips I am definitely crankier than normal.




Wait. NAC… do you mean NAD? Am I on the wrong planet and need to consider something different?

I think she means NAC, I read it somewhere else, but also NAD: I heard to give energy when anhedone. Do you IM ? because I really can't do it..
I'm 49, and perimenopausal and have history of depression.
I think you are right, it makes a person more susceptible to anhedonia, I also read if you have ADHD, and I do have some degree of ADD, no medicine.
I hope , it's better for you now on tirz, you must go slow. I'm so sorry it happened to you.
I just came to realize, I couldn't do it anymore, I loved tirz so much, but 10-11 mg, and I was just as flat as a pancake.
I do exercise a lot, 6 days a week, and I think, it does give some boost, but couldn't help with that.
Now Reta 5 mg.

 

[andreigl]

Miss-sanne this is the space I’m in: tirz plus NAD+.

I have tried all 3 of the current GLP-1s (short tries), and had anhedonia on all 3. On sema I got to week three and had to drop it, it was Very Much Not Good. It’s the reason I’ve tried all three, all short term partial doses.

As of today I’m 3 doses of tirz in, with roughly 3/week of NAD. So far it’s “okay” the anhedonia creeps through a tad here and there but the other morning I was cracking dad jokes at 6 am (definitely not my MO at F48, menopause-ish).

I have historically had anhedonia that dipped into depression. Seems likely that places me at greater tendency/ risk.

I am also not consistent with exercise (yet) and it’s a good weapon against this grey fog. 20 minutes of breath-moving activity (which a brisk walk works well for) was helpful for my “run of the mill” variety. Can’t say if it will help with this “induced” type but nothing to lose by trying.

My energy seems a little better than without, not sure it helps where really needed though, read: dopamine. When my energy dips I am definitely crankier than normal.




Wait. NAC… do you mean NAD? Am I on the wrong planet and need to consider something different?

N-acetylcysteine (NAC) has shown potential in reducing anhedonia, which is the inability to feel pleasure. Animal studies demonstrate that chronic NAC treatment can reverse anhedonic behaviors in models of depression and other conditions, and this effect is linked to improvements in neurotransmitter levels and brain structure, particularly in areas like the nucleus accumbens, a key part of the brain's reward circuitry. From Gemini AI

uuhh nac, as a tablet /capsule ? how much and how many times per day ? Should be easy to get TODAY lol

I always take the usual 600mg daily dose.