30mg Sema vials

[mountain_mist35]

Hi folks, I have 30mg vials coming my way. Now, I am thinking I will be throwing out a lot of Sema if I adhere to the 30-day rule (4 injections). On the max dose you would use 9.6mg of each vial which means I will be tossing out 20mg.
Did I make a mistake buying 30mg vials, and why would they even make 30mg vials? I plan to refrigerate and use sterile techniques. Could I pull 8 injections out of 1 vial?

 

[yelloeyes]

Hi folks, I have 30mg vials coming my way. Now, I am thinking I will be throwing out a lot of Sema if I adhere to the 30-day rule (4 injections). On the max dose you would use 9.6mg of each vial which means I will be tossing out 20mg.
Did I make a mistake buying 30mg vials, and why would they even make 30mg vials? I plan to refrigerate and use sterile techniques. Could I pull 8 injections out of 1 vial?

I would use them... but that is just me. I would at least pull 3 months out of them. Ozempic is 56 days... you will be using bac water. I have no idea what Novo uses.

 

[mountain_mist35]

I would use them... but that is just me. I would at least pull 3 months out of them. Ozempic is 56 days... you will be using bac water. I have no idea what Novo uses.

Thank you for reassurance!!

 

[SmokeySquid]

I have a 20mg vial that I have been using since mid October. Still clear and working fine afaik. Obviously check it for weird floaters or other nastiness before using but it should last for quite a while in the refrigerator.

 

[mountain_mist35]

I have a 20mg vial that I have been using since mid October. Still clear and working fine afaik. Obviously check it for weird floaters or other nastiness before using but it should last for quite a while in the refrigerator.

That's great to hear. I hate the idea of throwing it away. Have you noticed any potency loss, or is it exactly as it was when you first opened it? Thanks

 

[SmokeySquid]

That's great to hear. I hate the idea of throwing it away. Have you noticed any potency loss, or is it exactly as it was when you first opened it? Thanks

That is definitely hard to measure just by the “seat of my pants” but I am still loosing weight and it feels like it is working just fine. Sema for me is taken Monday and Thursday at .3 mg to help dull the hunger along with Tirz every 5 days for the food noise.

 

[mountain_mist35]

That is definitely hard to measure just by the “seat of my pants” but I am still loosing weight and it feels like it is working just fine. Sema for me is taken Monday and Thursday at .3 mg to help dull the hunger along with Tirz every 5 days for the food noise.

Very interesting. If you don't mind me asking about your dosing and what you started with, I'd like to know. Did you start 0.3 twice weekly? I started recently and followed standard guidance: 0.25 weekly on Tuesday. By Saturday/Sunday, my cravings are coming back. I know it is highly discouraged to start above 0.25 weekly, but I don't have side effects, and I feel I can up my dose. I am contemplating doing 0.25 twice weekly.

 

[penewbie]

Very interesting. If you don't mind me asking about your dosing and what you started with, I'd like to know. Did you start 0.3 twice weekly? I started recently and followed standard guidance: 0.25 weekly on Tuesday. By Saturday/Sunday, my cravings are coming back. I know it is highly discouraged to start above 0.25 weekly, but I don't have side effects, and I feel I can up my dose. I am contemplating doing 0.25 twice weekly.

Buying 30mg vials when you're on 0.25mg weekly is insane. Even just dosing that little is going to be difficult and inaccurate.

But you do you.

 

[mountain_mist35]

Buying 30mg vials when you're on 0.25mg weekly is insane. Even just dosing that little is going to be difficult and inaccurate.

But you do you.

I realized. I changed my order to 10mg vials. I don't think I will ever buy more than 10mg vials.

 

[SmokeySquid]

Very interesting. If you don't mind me asking about your dosing and what you started with, I'd like to know. Did you start 0.3 twice weekly? I started recently and followed standard guidance: 0.25 weekly on Tuesday. By Saturday/Sunday, my cravings are coming back. I know it is highly discouraged to start above 0.25 weekly, but I don't have side effects, and I feel I can up my dose. I am contemplating doing 0.25 twice weekly.

I have been adding .25 once a week since mid October so it isn't moving up all that much in the grand scheme of things.

Buying 30mg vials when you're on 0.25mg weekly is insane. Even just dosing that little is going to be difficult and inaccurate.

But you do you.

I ain't dead yet, but fair enough. They were purchased when I first started and didn't really know any better.

 

[Broken Chef]

I don't know where you heard 30 days...??? Fresh brand name pens have a 56 week shelf life and they start off at a lower purity than what we get. They don't add any kind of preservatives either . So...

I wouldn't hesitate to work out of a vial for 3 months. Just make sure it's kept at a steady temp in your fridge, doesn't freeze, doesn't get left out for an hour when you fill syringes.

Edit: And for that matter.. if it was 3 months old and you were worried about bacteria, you could spend $3 to filter it into a new sterile vial and go another x months.

 

[yelloeyes]

Very interesting. If you don't mind me asking about your dosing and what you started with, I'd like to know. Did you start 0.3 twice weekly? I started recently and followed standard guidance: 0.25 weekly on Tuesday. By Saturday/Sunday, my cravings are coming back. I know it is highly discouraged to start above 0.25 weekly, but I don't have side effects, and I feel I can up my dose. I am contemplating doing 0.25 twice weekly.

Bump it to .5

 

[Broken Chef]

Very interesting. If you don't mind me asking about your dosing and what you started with, I'd like to know. Did you start 0.3 twice weekly? I started recently and followed standard guidance: 0.25 weekly on Tuesday. By Saturday/Sunday, my cravings are coming back. I know it is highly discouraged to start above 0.25 weekly, but I don't have side effects, and I feel I can up my dose. I am contemplating doing 0.25 twice weekly.

I'll trade you my 12.5mg vials for your 30's, then you won't have to feel bad, lol jk

Sema has a 5 day half life - that's why it wans at day 4/5. I'm honestly a bit shocked you are getting any help at all from .25mg!

I went 3 weeks on each dose and didn't notice any help at all until I hit 1mg.. then experienced what you are - about 4 days of help.

Don't be in a rush to increase your dose if it's working for you! If you are getting adequate help for 4 days on .25mg, I'd say try another .25 3-4 days out from first dose. Milk that low dose as long as you can! Then it will take longer to work up to the full dose and you'll hopefully reach your goal before you have to switch or add something else.

I don't think it ever lasted a full 7 days for me, I was always eating more and snacking on days 6-7.

15 months later I'm up to 3.5mg weekly with .75mg cagri 3 and 5 days after.

I've stalled twice... First time cagri broke my stall, second time I increased from 2.4 to 3mg, then to 3.5mg and that broke it.

 

[mountain_mist35]

I'll trade you my 12.5mg vials for your 30's, then you won't have to feel bad, lol jk

Sema has a 5 day half life - that's why it wans at day 4/5. I'm honestly a bit shocked you are getting any help at all from .25mg!

I went 3 weeks on each dose and didn't notice any help at all until I hit 1mg.. then experienced what you are - about 4 days of help.

Don't be in a rush to increase your dose if it's working for you! If you are getting adequate help for 4 days on .25mg, I'd say try another .25 3-4 days out from first dose. Milk that low dose as long as you can! Then it will take longer to work up to the full dose and you'll hopefully reach your goal before you have to switch or add something else.

I don't think it ever lasted a full 7 days for me, I was always eating more and snacking on days 6-7.

15 months later I'm up to 3.5mg weekly with .75mg cagri 3 and 5 days after.

I've stalled twice... First time cagri broke my stall, second time I increased from 2.4 to 3mg, then to 3.5mg and that broke it.

Thanks for the feedback and suggestions.

I saw on various sites that you should aim to use your reconstituted peptides within 28 or 30 days. But I did not plan on following that guidance from the start.

Regarding the dose, I am getting super hungry now. I don't think 0.25 is working for me anymore, and I need to up my dose. I think I will go to 0.5 and give it 7 days, but if I notice cravings, I might do it every 5 days.

Did you have any side effects from any dose you took? I personally don't know anyone who's taking 3.5 Sema, so I'm very curious how you feel about that dose.

Also, I was thinking about something else. I will be getting new vials from another supplier. Should I start with a lower dose just to gauge how I'm going to feel, or should I take new vials with my current actual dose? Thoughts?

 

[YoYoFat]

Buying 30mg vials when you're on 0.25mg weekly is insane. Even just dosing that little is going to be difficult and inaccurate.

But you do you.

Buying 30mg vials when you’re on max dose of 2.4mg is also silly.

I’m surprised they even make Sema that big.

 

[YoYoFat]

I don't know where you heard 30 days...??? Fresh brand name pens have a 56 week shelf life and they start off at a lower purity than what we get. They don't add any kind of preservatives either . So...

I wouldn't hesitate to work out of a vial for 3 months. Just make sure it's kept at a steady temp in your fridge, doesn't freeze, doesn't get left out for an hour when you fill syringes.

Edit: And for that matter.. if it was 3 months old and you were worried about bacteria, you could spend $3 to filter it into a new sterile vial and go another x months.

30 days is best practices for reconstituted vials.

Pens aren’t the same.

 

[Broken Chef]

Thanks for the feedback and suggestions.

I saw on various sites that you should aim to use your reconstituted peptides within 28 or 30 days. But I did not plan on following that guidance from the start.

Regarding the dose, I am getting super hungry now. I don't think 0.25 is working for me anymore, and I need to up my dose. I think I will go to 0.5 and give it 7 days, but if I notice cravings, I might do it every 5 days.

Did you have any side effects from any dose you took? I personally don't know anyone who's taking 3.5 Sema, so I'm very curious how you feel about that dose.

Also, I was thinking about something else. I will be getting new vials from another supplier. Should I start with a lower dose just to gauge how I'm going to feel, or should I take new vials with my current actual dose? Thoughts?

I had some cramping once I hit 2mg, but as the months went on, it got to the point where I didn't have any issues and eventually felt like it wasn't working, so I increased the dose until it started working again.

I have a high tolerance for most meds and my tolerance builds fast. Almost everything I've ever taken stops working within a year and I have to increase the dose.

I would not start over or cut back with a new vendor, but I always recon based on the test results, not what the vial is claimed to be. The 12.5mg I have were sold as 10mg, but testing showed 12.5.

I guess it depends on where you buy from though.. how they run their testing, and if you can trust the results.

I had sema from a domestic vendor that was most definitely under filled to maybe 3/4 of the test they showed me. I now use gb's who randomly test vials from the product received... I don't trust a vendor showing me a test - it's way too easy to send something from a different batch.

I use gb's who spend $150-200k/month with the same vendor - giving the vendor 2 million reasons a year to make good on what they supply.

 

[rkl123]

Buying 30mg vials when you’re on max dose of 2.4mg is also silly.

I’m surprised they even make Sema that big.

Imagine if somebody shared a vial with loved one.

 

[Broken Chef]

Imagine if somebody shared a vial with loved one.

If I didn't already have a bunch, I would have got some 30's. Got 2 people here on sema - one on 3.5/week, another on 2.5/week. I recon three 12.5mg at a time and filter into a 5ml vial.

 

[Broken Chef]

30 days is best practices for reconstituted vials.

Pens aren’t the same.

I don't know who you've been talking to, but the majority of people I've talked to over the last 8 months run 2-3 months out of a recon'd vial, and I've talked with several others, including vendors who have been doing this for decades, who use stuff that's been in the fridge for 6 months without issue.