8 Week break from GLP'S?

Seamus

GLP-1 Novice
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Oct 14, 2025
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Anyone been on a high dose of Tirz or Reta,then it slowed down and you took a break to 'reset'?

If so how long was it for,and did it work??
 
Following. I’ve heard for some it never gives them the same suppression after they’ve stopped and restarted, and for others they do.
Yes this is what I've been reading.. Instead of having a break I've just added Tirz to my high dose of Reta..I have my last few stubborn KGs to loose.. I'm thinking if I have a break,second time around it'll be pointless..
 
Anyone been on a high dose of Tirz or Reta,then it slowed down and you took a break to 'reset'?

If so how long was it for,and did it work??
I’ve been on Sema (.2/wk) and Reta (.7/wk) with no intention of coming off at any point. Would you consider lowering to your starting dose again so you don’t have to suffer the same acclimation symptoms? When you get a prescription they make you start over if you’ve been off for 5 weeks which leads me to believe that’s the point at which the stacked half-lives are fully depleted.
 
I’ve been on Sema (.2/wk) and Reta (.7/wk) with no intention of coming off at any point. Would you consider lowering to your starting dose again so you don’t have to suffer the same acclimation symptoms? When you get a prescription they make you start over if you’ve been off for 5 weeks which leads me to believe that’s the point at which the stacked half-lives are fully depleted.
Why such low doses of both though? Wouldn't it be better to Tirate up one first?
 
Why such low doses of both though? Wouldn't it be better to Tirate up one first?
My BMI is 20 and I find it hard to gain weight already. I’m microdosing to suppress the activation of microglia and astrocytes, as well as the neuroprotective mechanisms like synaptic plasticity and enhancing the expression of BDNF. I also like the accelerated wound healing and anti-inflammation. I tried .5-1mg Sema and 1-2mg Reta at one point, lost 13 lbs in under a month and looked like I was starving to death. I also lost all my energy, bad combo.
 
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