Anyone else experiencing Allodynia (skin sensitivity) while on Tirzepatide? Please share your experiences?

[Desertteepee2]

I’m near the end of my 9th month on Tirzepatide. Never went above 5.0 mg. I’ve lost 45lbs and all my health metrics have returned to normal levels, like BP, A1c, lipids, cognition, etc. Switched from branded Mounjaro to compounded Tirz. in July. All along the way I have experienced Allodynia (skin sensitivity). I’ve had only a couple of periods where it subsided. It’s generally always there. Sometimes the whole envelope of my body and sometimes spot areas like my upper arms or my flanks or fingers. It’s tolerable, so it never threatened my commitment to the medication…in fact, I’ve learned to use it as an indication that I know the meds are working. I’m just curious about other people’s experiences with this side effect. Also if anyone has a clue about how to subdue it.

 

[gman1]

Yes, a bit similar. 8th month and at 3.5mg per week. Down 51 pounds and at target weight. Some itching on stomach and calves, treated with 1% hydrocortisone cream. If this is the price I pay for a healthy weight that's OK with me.

 

[OSU618]

Yep! Sure do! I’ve been on a low dose of tirz only increasing .5mg from the start and have started to have allodynia the past few weeks. To me it feels like a buzzing under the skin and goosebumps at the weirdest times. At first I was totally freaked out and worried it was a histamine reaction that would get worse but have since noticed it is its own situation. I find that an antihistamine, workouts and sauna seem to ease it the most for me.
Interested to hear any other remedies folks have found.

 

[geoguy78]

Yes. Frequently. Usually on my hands or feet, and usually for just a couple days post-injection. But I don't get it with every injection. I had a particularly bad episode on my right hand about a month ago. This morning I felt it on a foot but it's gone already. Really random

 

[normal]

I get it randomly on my arm, patches feel a little sunburntish to the touch. I don't really think much about it to be honest. Week 25.

 

[Dame Itbobby]

Yes! Feels like burning/nerve pain for me - like what shingles felt like. Usually the first few days after my dose. No idea what causes it and wish I had a solution.