Anyone tried tirz every other day?

[Calm Logic]

It certainly would go against the grain.

I see some taking it every four or five days, such as to minimize fatigue or to minimize food noise during the last couple days of the weekly schedule.

So I was thinking, why not just every other day? But since tirz has a half life of five days, I guess there is not as much additional benefit.

Google Gemini also warns about possible "suboptimal efficacy" with anything other than the recommended weekly schedule:

It's important to understand that Tirzepatide is designed to be administered once weekly. There is no established or recommended dosing schedule for taking a weekly equivalent dose every other day.

Splitting the weekly dose and taking it more frequently could potentially lead to:

• Increased side effects: More frequent administration might increase the likelihood or severity of gastrointestinal side effects.
  
  
• Suboptimal efficacy: The pharmacokinetics and pharmacodynamics of tirzepatide are designed for a once-weekly injection. Altering this schedule could affect how the medication works in your body and may not provide the intended benefits.
  
  
• Unpredictable results: There is no data on the safety and efficacy of taking tirzepatide every other day.

Therefore, it is strongly recommended that you follow the once-weekly dosing schedule prescribed by your doctor.

While an every-other-day dosing schedule for tirzepatide might theoretically offer some benefits in terms of tolerability or more stable drug levels, it is not a recommended or studied approach. The potential cons, including the lack of clinical data and increased injection burden, along with the importance of adhering to the prescribed regimen, make this an off-label and potentially risky approach without explicit medical guidance.

 

[General Lee]

I tried it with reta, one big dose definitely had a better effect for me. Even twice week it just didn’t work the same. Can’t explain why, It just seemed far more effective. Whatever the Lily trials do is what I’d recommend really. Plus you have the added risk of infection etc pinning so many times.

 

[Calm Logic]

Thanks, the weekly dosing also jibes with this:

While peak concentrations occur within a few days, the clinical effects of tirzepatide, such as blood sugar control and weight loss, develop over a longer period as the medication works to regulate hormones and metabolism.

And when I asked my internist about taking it every five days, he said just increase the weekly dose.

 

[General Lee]

Thanks, the weekly dosing also jibes with this:



And when I asked my internist about taking it every five days, he said just increase the weekly dose.

That makes perfect sense man. Totally explains why. I was on 10mg of reta, Switched to 2mg of Reta as per some sleazy salesmans advice and it had NO effect whatsoever, Oh actually no the appetite suppression was still prevalent but that could have just been the tirz still in my system. I’m now on 10mg of reta and it feels just like the Tirz did (unsurprisingly).