Bacteriostatic Solution Sodium Chloride

[Jaylee]

Has anyone used the Pfizer Injection Bacteriostatic Solution Sodium Chloride (Hospira) Green top, to reconstitute any of their peptides?

 

[bbrewer]

Has anyone used the Pfizer Injection Bacteriostatic Solution Sodium Chloride (Hospira) Green top, to reconstitute any of their peptides?

There is some concern that the salt can interfere with the peptide function by changing how it folds. It would probably take a lot of digging to sort it out.

 

[scarywood75]

There is some concern that the salt can interfere with the peptide function by changing how it folds. It would probably take a lot of digging to sort it out.

It indeed cannot be used on all peptide, like BAC isn't always appropriate for pH reasons, but saline BAC is better for the most part

It makes the injection more comfortable

 

[Calm Logic]

The ingredients in Zepbound:

Active ingredient: tirzepatide. Inactive ingredients: sodium chloride, sodium phosphate dibasic heptahydrate, and water for injection.

For Wegovy:

Active Ingredient: semaglutide

Inactive Ingredients: disodium phosphate dihydrate, 1.42 mg; sodium chloride, 8.25 mg; water for injection; and hydrochloric acid or sodium hydroxide may be added to adjust pH.

According to Google Gemini:

In the context of tirzepatide reconstitution, the 0.9% sodium chloride in bacteriostatic water helps to create a physiologically compatible solution for injection while the bacteriostatic agent ensures the sterility of multi-dose vials. The sodium chloride itself is not expected to have a direct therapeutic effect or significantly alter the activity of tirzepatide when used as a diluent according to the product guidelines.

 

[TooBigtoFail]

Nacl is to make the solution more isotonic. From the Tirz patent: It is further desirable to match the tonicity (i.e., osmolality) of body fluids at the injection site as closely as possible when administering the compositions because solutions that are not approximately isotonic with body fluids can produce a painful stinging sensation when administered. It is desirable that the compositions be approximately isotonic with body fluids at the sites of injection. The present composition comprising tirzepatide, NaCl, and dibasic sodium phosphate is associated acceptable patient injection site experience. Likewise, the composition comprising tirzepatide, proplylene glycol, and dibasic sodium phosphate is associated with acceptable patient injection site experience. .....