Chart Showing Comparative Activation of Different Receptors by GLP-1 Drugs Involved

[keangkong]

I saw a chart repeatedly showing the supposed potencies of different weight loss drugs in humans. I assumed that the information in it was wrong, but when I checked, everything matched scholarly sources.

The profiled drugs are semaglutide, tirzepatide, retatrutide, mazdutide, and survodutide.

I realize that there are caveats I should be adding on using the data but I'm so inexpert in this field that I can't even explain well the reason for the caveats.

I'm adding an image of the chart along with sources. I'm also attaching a .pdf document, which will permit you to click on the hyperlinks in order to access the source documents without having to go through a paywall.

 

[PopTart]

Thanks for pulling this together!

 

[indolent]

Thanks.

This seems an important concept for stall-breaking, and a reason to avoid simplistic "more agonists = better" thinking.

Each of the receptors has a primary association with a desirable effect (food noise suppression, gastric slowing, energy allocation or whatever). So switching or stacking retatrutide, for example, might not efficiently solve a patient's particular stall problem.

I'd try to list those associations, but I don't want to do it incorrectly off the top of my head, and right now I'm busy taking a train from Agrigento to Palermo.

 

[YoYoFat]

I saw a chart repeatedly showing the supposed potencies of different weight loss drugs in humans. I assumed that the information in it was wrong, but when I checked, everything matched scholarly sources.

The profiled drugs are semaglutide, tirzepatide, retatrutide, mazdutide, and survodutide.

I realize that there are caveats I should be adding on using the data but I'm so inexpert in this field that I can't even explain well the reason for the caveats.

I'm adding an image of the chart along with sources. I'm also attaching a .pdf document, which will permit you to click on the hyperlinks in order to access the source documents without having to go through a paywall.

Did that chart come from a study or was it created by someone interpreting the studies? Because I’ve seen other charts which switch the GLP and GIP numbers for Tirz (less GLP in Tirz than Sema), which makes a lot more sense to me than this one given how Tirz is so much better tolerated than Sema.

 

[IshimaruKenta]

 

[miss-sanne]

Did that chart come from a study or was it created by someone interpreting the studies? Because I’ve seen other charts which switch the GLP and GIP numbers for Tirz (less GLP in Tirz than Sema), which makes a lot more sense to me than this one given how Tirz is so much better tolerated than Sema.

The Chart does not show humans response.
It came from in vitro studies.
So it's really all theory, because not testet on humans.
Nobody knows if humans have the same.