Well, I did another injection with my stinging batch and it has been reconstituted for a week so...
Do y’all test every time you order? re: Amopure stinging
- Thread starter Sseker
- Start date
Tinygrashopa
Recently Joined
I bought L20 3 weeks ago and my RS has had no sting with 2 injections. Great appetite suppression and down 9lbs.
seanc34
GLP-1 Novice
my L60 arrived today crazy like 3-4 days after purchase. Global logistics is a crazy thing
Really? Mine is on its way. Ordered Monday.
I’ve seen reports of stinging from June, July and August orders and from before and after they started vacuum sealing.
I would feel a lot better if we can figure out the source (likely ph or filament… but could be something more serious like sterility)
I would feel a lot better if we can figure out the source (likely ph or filament… but could be something more serious like sterility)
I feel you. Im seriously thinking of getting a syringe filter to address that somewhat chance of not knowing if whatever is causing that stinging or burning is harmful or not. Test results will not show it as they don't check for it and not having information from Amopure when they likely know what caused it (since they corrected it) is only causing more uncertainty. It's easy to give in hoping nothing will happen when one thing RS shouldn't compromise is the safety element and leave it on chance.
My only concern is if I'm going to actually add more contamination through the filtering process because there are multiple steps involved, including transferring into a completely new vial, ensuring it's sterile etc etc. Because that will defeat the entire purpose.
I don’t think they have fixed it since people are still experiencing the stinging/burning after they initially stated they fixed it (it’s why they went to vacuum sealed vials).
Has anyone tried to push the issue with them at all to see if they have an answer as to the why?
There is a big test of T30/T60 that includes sterility testing so hopefully it rules it out..
Next is to figure out the ph of the stinging vials (only seen ph for one non stinging vial that was slightly acidic). And even then if the ph is too high or too low is this actually going to hurt the RS or is it just a minor discomfort when injecting?
There are test to check the fillament used too that might be helpful to do….
geoguy78
GLP-1 Specialist
I honestly don't see how not being sterile would cause stinging, especially on a freshly reconstituted vial where there hasn't been the opportunity for microbial growth. I have a feeling that they might have some residual from the manufacturing process that some people are sensitive too. But that's just my hunch. I have a kit of T30 on the way so I will find out soon enough whether it stings or not.
moonpies4misfits
GLP-1 Specialist
Yeah I keep hoping to see someone has PH tested their stinging vial but so far no dice. It would also be helpful to see the PH of their bac water before constituting as a side by side comparison.
Curious if anyone would be willing to swap a non-stinging vial with a stinging vial and see if it stings for both parties. It may be that some people are more sensitive to whatever is causing it.
I also wonder if anyone has reported stinging from one vial and no stinging from another vial from the same kit.
Yeah - my guess is it’s either ph or the filler that is causing issues.
Just got my pep pen that I bought after the research ROI pen was a dud and they refunded me. Will use for the Glow Protocol.
zpped
Moderator
I had an exchange of emails with Amo about this the other day and long story short he can't or wont say what exactly the problem is. He acknowledges it and has reshipped product for anyone experiencing the issue that contacts him. He claims it's ~3-4% and that it happens to every vendor...? But I would say that "he fixed it" is not an accurate description at this point.
Obviously not an ideal response but there you have it. It doesn't put me off doing future business with them.
Now people have speculated what issue could be. It's almost definitely not a sanitary issue. The best theory I've seen is TFA which is an acid used in the manufacturing process that might not have been completely removed. I have not seen a ph test on any confirmed stinging vials.
Obviously not an ideal response but there you have it. It doesn't put me off doing future business with them.
Now people have speculated what issue could be. It's almost definitely not a sanitary issue. The best theory I've seen is TFA which is an acid used in the manufacturing process that might not have been completely removed. I have not seen a ph test on any confirmed stinging vials.
That’s similar to the response I got… not that reassuring given I don’t see any other major supplier having reports of stinging/burning.
zpped
Moderator
I have, but Amo also does something different in their manufacturing process by not including mannitol. Who knows if that has an effect.
Amopure is one of the few suppliers without a discord or telegram channel or named salesperson as well which makes it a little harder to get answers like this answered.
I would be interested in doing a test to identify the fillament they are using since it’s not mannitol
geoguy78
GLP-1 Specialist
Looks like my T30 is arriving today. I still have 4 weeks of compounded tirz so it will be a while before I pin it. Right now I'm debating sending a vial in for testing. There's currently a big group test happening that plans to release the results publicly so I don't know.... The test will cost almost as much as the kit and won't tell me anything about everything else in the vial (fillers, contaminants, etc..) so we will see....
Yeah, given the size and how recent that test is likely diminishing returns (of course there is nothing like testing your own batch)
This large test will include sterility which is good…
There are tests that can be done to figure out the primary filler used, but that’s not part of this test, but I think that’s likely the next one to do
Gwenhwyfar227
GLP-1 Enthusiast
The results have been trickling in on Peppys btw...so far good results as far as the fill amounts and percentage.
We know the stinging is not because of lower purity or lower sterility so not sure how much help are those tests in identifying the root cause. Unless someone from Amopure provides a definite answer, we are just guessing here.
geoguy78
GLP-1 Specialist
All the recent tests have been proper fill level and high purity. Unfortunately, like you are saying, the standard testing won't point us towards the culprit. I seriously doubt the sterility testing being done right now will show anything either. I'll bet there's a residual from manufacture that is causing it. That being said, my batch of T30 came today, just six days after I ordered. I will find out in a few weeks whether it stings or not
Gwenhwyfar227
GLP-1 Enthusiast
This wasn't what I was referring to. I was referring to the large group testing..thanks
Obvious not conclusive but I’m pretty sure I’ve seen users on this forum claim stinging from T10, T15, and T30 but haven’t seen anything solid on T60 or any R.
GustyWinds
GLP-1 Novice
There’s two folks with late August purchase of R10 (my RS being one) in another thread both experiencing same sting.
Reta thread has similar reports on stinging.
Not sure why you are saying we know this is not because of lower sterility, since (as we have discussed to exhaustion in other forums) there really is no good test for sterility / contamination. I think someone else's comment implied a freshly mixed vial should be sterile / uncontaminated, but bac water does not kill existing bacteria, it only slows the growth.
zpped
Moderator
You are correct that there is no great test for sterility as most people think. But the right way to frame it is that it's unlikely a sterility issue because that isn't how they manifest. The mere presence of bacteria doesn't present as burning, that comes from the body's antibody response.
geoguy78
GLP-1 Specialist
This is why I think people are way too focused on sterility, and some are even spreading unfounded claims that Amo has sterility issues. A sterility problem would cause after-the-fact injection site infections, not instant burning. This issue is more likely an irritant leftover from the manufacturing process.
raw_oyster_eater
lemon bottle brewer
How much hay needs to be made of this? You start googling around and find stories of Ozempic, Wegovy, Zepbound and such stinging on injection as well. You gonna get a refund from them too?
I agree that if it was a sterility issue, there would be longer lasting symptoms and no one seems to be reporting that, although I don't agree it wouldn't also cause an immediate response as the body goes to work fighting off invaders.
It would be helpful if Amo would just be clear about what they think the "resolved" issue was, but seems unlikely they're going to do that.
